동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제25권3호
  • /
  • Pages.510-515
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  • 2011
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  • 1738-7698(pISSN)
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  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

절패모(浙貝母) 에탄올 추출물의 멜라닌 생성 억제 효과

Inhibitory Effect of Fritillaria Verticillata Willd. var. Thunbergii Bak Ethanol Extract on Melanin Biosynthesis

  • 하태광 (상지대학교 한의과대학, 본초학교실) ;
  • 이부균 (세명대학교 본초방제학교실) ;
  • 윤정록 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 문연자 (원광대학교 한의과대학 해부학교실) ;
  • 우원홍 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 박성하 (부산대학교 한의학전문대학원 약물의학부) ;
  • 이장천 (부산대학교 한의학전문대학원 약물의학부)
  • Ha, Tae-Kwang (Department of Herbology, College of Oriental Medicine, Sangji University) ;
  • Lee, Boo-Kyun (Department of Herbology & Prescriptionology, College of Oriental Medicine, Semyung University) ;
  • Yoon, Jeong-Rock (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Mun, Yeun-Ja (Department of Anatomy, College of Oriental Medicine, Wonkwang University) ;
  • Woo, Won-Hong (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Park, Seong-Ha (Division of Pharmacology and Basic Korean Medicine, School of Korean Medicine, Pusan National University) ;
  • Lee, Jang-Cheon (Division of Pharmacology and Basic Korean Medicine, School of Korean Medicine, Pusan National University)
  • 투고 : 2011.04.14
  • 심사 : 2011.06.08
  • 발행 : 2011.06.25
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초록

This study was conducted to evaluate the depigmenting properties of ethanol extract from a Fritillaria verticillata Willd. (EFV) in B16F10 cells. Fritillaria verticillata Willd., a perennial herbaceous plant, has been used as a stimulator of mammary gland, expectorant, blood pressure depressant, antitussive agents in Korean herbal medicine. In the present study, we observed that melanin synthesis of B16F10 cells were significantly decreased by EFV without cytotoxicity. However, EFV could not suppress tyrosinase activity in B16F10 cells and mushroom tyrosinase activity. Furthermore, EFV did not effect the protein expression of tyrosinase, tyrosinase-related protein -1 (TRP-1), and TRP-2. These results suggest that EFV inhibited melanin synthesis and the hypopigmentary effect of EVF was not due to regulation of tyrosinase protein.

키워드

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