Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Olibanum Extracts on Vascular Cell Adhesion Molecules Expression

유향 추출물이 혈관내피세포 부착단백질 발현에 미치는 영향

  • Lee, Soong-In (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Kwon, Kang-Beom (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Han, Jong-Hyun (Department of Pharmacology, College of Oriental Medicine, Wonkwang University) ;
  • Ryu, Do-Gon (Department of Physiology, College of Oriental Medicine, Wonkwang University)
  • 이숭인 (원광대학교 한의과대학 한방생리학교실) ;
  • 권강범 (원광대학교 한의과대학 한방생리학교실) ;
  • 한종현 (원광대학교 한의과대학 약리학교실) ;
  • 류도곤 (원광대학교 한의과대학 한방생리학교실)
  • Received : 2011.03.04
  • Accepted : 2011.05.30
  • Published : 2011.06.25
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Abstract

In order to validate the use of Olibanum as an anti-inflammatory drug in the traditional Korean medicine, I have investigated the effect of water-soluble extract of Olibanum (EO) on the expression of pro-inflammatory vascular cell adhesion molecule-1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs) stimulated with tumor necrosis factor-${\alpha}$. The extract inhibited dose-dependently VCAM-1 expression without its cytotoxic effect on HUVECs, as measured by a flow cytometer using fluorescence-enhanced anti-VCAM-1 antibody, and significantly decreased mRNA levels of VCAM-1, as determined using reverse transcription polymerase chain reaction. These results suggest that Olibanum may have therapeutic potential in the control of endothelial disorders caused by inflammation.

Keywords

References

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