동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제25권1호
  • /
  • Pages.115-121
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  • 2011
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  • 1738-7698(pISSN)
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  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

흑삼의 항산화 활성

Antioxidant Activity of Black Panax ginseng

  • 이숙영 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 김동희 (대전대학교 한의과대학 한의학과) ;
  • 우원홍 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Lee, Sook-Young (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kim, Dong-Hee (Department of Herbalogy, College of Oriental Medicine, Daejeon University) ;
  • Woo, Won-Hong (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 투고 : 2011.01.10
  • 심사 : 2011.02.14
  • 발행 : 2011.02.25
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초록

This study was performed to investigate the antioxidant activity of extracts of black Panax ginseng (BGE) and its crude saponin (BGECS). The antioxidant activities of BGE and BGECS were evaluated for free radical scavenging activity against stable free radical (1,1-diphenyl-2-picrylhydrazyl) DPPH, nitrite, hydrogen peroxide and superoxide. In addition, the antioxidant activity of BGE and BGECS against peroxyl radicals, hydroxyl radicals and peroxynitrites were determined by the total oxy-radical scavenging capacity (TOSC) assay. As a result, BGE and BGECS were found to have a strong inhibitory activity with >90% against the DPPH radical at $1000{\mu}g/m{\ell}$ concentrations. Also, BGE and BGECS exhibited strong inhibitory activity with >80% against hydrogen peroxide at lower concentration ($125{\mu}g/m{\ell}$). Moreover, specific TOSC values (405 and 473 TOSC/mM) of BGE and BGECS against peroxynitrites were higher than GSH (347 TOSC/mM) used a positive control. These results suggest that BGE and BGECS could be useful to develop functional foods against disease related oxidative stress.

키워드

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