Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Screening of Antioxidative Effect and Suppressive Effect of LDL Oxidation of Euryale ferox Salisbury

Euryale ferox Salisbury의 항산화효과 및 LDL 산화 억제효과 탐색

  • Kim, Young-Hwan (Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Lee, Min-Ja (Institute of Oriental Medicine, College of Oriental Medicine, Dongguk University) ;
  • Lee, Hye-Sook (Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Kim, Jung-Guk (Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Park, Won-Hwan (Department of Diagnostics, College of Oriental Medicine, Dongguk University)
  • 김영환 (동국대학교 한의과대학 진단학교실) ;
  • 이민자 (동국대학교 한의학연구소) ;
  • 이혜숙 (동국대학교 한의과대학 진단학교실) ;
  • 김정국 (동국대학교 한의과대학 진단학교실) ;
  • 박원환 (동국대학교 한의과대학 진단학교실)
  • Received : 2010.11.22
  • Accepted : 2011.02.11
  • Published : 2011.02.25
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Abstract

Topical natural antioxidants are a useful strategy for the prevention of oxidative stress mediated cardiovascular disease including atherosclerosis. From the viewpoint of this underlying principle, the screening of natural plant extracts with scavenging activity for pro-oxidant reactive species is a primary requirement for the development of new topical antioxidant formulations. Euryale ferox Salisbury (EF) is botanical name and it's pharmaceutical name is EURYALES SEMEN (ES). The stems and branchs of EF have been used as a traditional herbal medicine for the treatment of dysentery, diarrhea, leucorrhoea, incontinence and paralysis of joint. In this study, the antioxidant activity of extract from EF was studied in vitro methods by measuring the antioxidant activity and free radical scavenging activity by TEAC and DPPH, measuring the scavenging effects on reactive oxygen species (ROS) [superoxide anion, hydroxyl radical] and on reactive nitrogen species (RNS) [nitric oxide and peroxynitrite] as well as measuring the inhibitory effect on $Cu^{2+}$-induced human LDL oxidation. The EF extracts were found to have a potent scavenging activity, as well as an inhibitory effect on LDL oxidation. In conclusion, the EF extracts have antioxidative effects in vitro system, which can be used for developing pharmaceutical drug against oxidative stress and chronic degenerative disease such as atherosclerosis.

Keywords

References

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