The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effects of Sojongchobisunki-tang on Cisplatin-induced Rat Acute Renal Failure

소종조비순기탕(消腫調脾順氣湯)이 Cisplatin으로 유발(誘發)된 흰쥐의 급성신부전(急性腎不全)에 미치는 영향

  • Yoon, Gyeong-Min (Dept. of Oriental Internal Medicine, Graduate School, Daegu Haany University) ;
  • Kang, Seok-Bong (Dept. of Oriental Internal Medicine, Graduate School, Daegu Haany University)
  • 윤경민 (대구한의대학교 부속한방병원 신계내과학교실) ;
  • 강석봉 (대구한의대학교 부속한방병원 신계내과학교실)
  • Published : 2011.06.30
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Abstract

Objectives : The object of this study was to observe the nephroprotective effects of Sojongchobisunki-tang (SCST), which has traditionally been used as Korean medicine for treating various renal diseases, on cisplatin-induced rat acute renal failure. Methods : Three different dosages of SCST were orally administered once a day for 23 days before cisplatin treatment (5 mg/kg, single intraperitoneally administered) and 5 days after cisplatin treatment (once a day for 28 days). 6 groups, of 8 rats per group were used in the present study after 7 days of acclimatization. Changes of the body weight, kidney weight, serum BUN and creatinine levels were observed, as well as changes of the kidney MDA and GSH contents. The results were compared with captopril 100 mg/kg of which the effects on cisplatin-induced acute renal failures are already confirmed. Results : Acute renal failure induced by cisplatin were induced by oxidative stress and related lipid peroxidation in the present study. However, these acute renal failures and inhibition of antioxidant effects induced by cisplatin were dose-dependently reduced by treatment at all three different dosages of SCST extracts. Conclusions : This study suggests that SCST extracts showed favorable effects on the cisplatin-induced rat ARF.

Keywords

References

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