대한한의학방제학회지 (Herbal Formula Science)

  • 제19권1호
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  • Pages.145-160
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  • 2011
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  • 1229-1218(pISSN)
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  • 2288-5641(eISSN)
대한한의학방제학회 (The Korean Medicine Society for the Herbal Formula Study)
권호 표지
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숙지황(Rehmannia glutinosa)의 약리작용과 독성

Pharmacological Action and Toxicity of Rehmannia glutinosa

  • 박영철 (대구가톨릭대학교 GLP 센터) ;
  • 이기용 (대구가톨릭대학교 GLP 센터) ;
  • 백낙민 (대구가톨릭대학교 GLP 센터) ;
  • 손혜영 (대구가톨릭대학교 GLP 센터) ;
  • 국윤범 (상지대학교 한의과대학 방제학교실) ;
  • 이선동 (상지대학교 한의과대학 예방의학교실)
  • Park, Yeong-Chul (GLP Center, Catholic University of Daegu) ;
  • Lee, Gi-Yong (GLP Center, Catholic University of Daegu) ;
  • Baek, Lag-Min (GLP Center, Catholic University of Daegu) ;
  • Son, Hye-Young (GLP Center, Catholic University of Daegu) ;
  • Kook, Yoon-Boom (Dept. of Formula Science, School of Oriental Medicine, Sang-Ji University) ;
  • Lee, Sun-Dong (Dept. of Preventive medicine, School of Oriental Medicine, Sang-Ji University)
  • 투고 : 2011.04.19
  • 심사 : 2011.06.13
  • 발행 : 2011.06.30
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초록

Objectives : Rehmannia glutinosa has been used extensively in Korean traditional medicine. Although thorough clinical trials are lacking, Various pharmacological actions for Rehmannia glutinosa has been identified newly using animal models. In addition, it was reported that reactive intermediates, potentially causing toxic effects, was isolated from one of components in Rehmannia glutinosa. In this article, it is purposed for explanation and introduction of new studies for Rehmannia glutinosa in terms of pharmacological action and toxicology. Methods : New studies for Rehmannia glutinosa were reviewed and summarized in terms of pharmacological action and toxicity. Results and Conclusions : Rhmannia glutinosa and its components including iridoids, saccharides, as well as amino acid, showed a variety of pharmacological actions on the blood system, immune system, endocrine system, cardiovascular system and the nervous system. In addition, it was identified that aucubin, one of major components of Rhmannia glutinosa was biotransformed to reactive intermediates by ${\beta}$-glycosidase and acid-hydrolysis, resulting in forming aucubigenin- albumin adduct. Even if a lot of new pharmacological actions has been identified, it should be considered for Rhmannia glutinosa to contain the material producing reactive intermediates which may induce the side effects.

키워드

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