Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Antagonistic Effects of Atipamezole and Yohimbine on Medetomidine-Midazolam-Ketamine Anesthesia in Beagle Dogs

비글견에서 medetomidine-midazolam-ketamine 마취에 대한 atipamezole과 yohimbine의 길항효과

  • Hwang, Hag-Kyun (Research Institute of Veterinary Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Lee, Jae-Yeon (Research Institute of Veterinary Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Jeong, Seong-Mok (Research Institute of Veterinary Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Myung-Cbeol (Research Institute of Veterinary Medicine, College of Veterinary Medicine, Chungnam National University)
  • Accepted : 2011.04.04
  • Published : 2011.04.30
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Abstract

The aims of this study were to investigate the anesthetic effects of medetomidine-midazolam-ketamine (MMK) combination and to compare antagonistic effects of atipamezole and yohimbine in dogs anesthetized with MMK. Eighteen adult male healthy beagles were used in this study. All dogs were anesthetized with intramuscular (IM) administration of medetomidine (0.04 mg/kg), midazolam (0.2 mg/kg) and ketamine (5 mg/kg) in one syringe. Intravenous (IV) administration of atipamezole (0.24 mg/kg, MMKA), yohimbine (0.2 mg/kg, MMKY) or saline solution (0.1 ml/kg, MMK) was administered 20 minutes after MMK combination anesthesia. Induction and recovery times, scores of sedation and analgesia, heart rate, blood pressure, rectal temperature, respiratory rate and blood gases were determined and recorded for each dog. Mean anesthesia times, sternal recumbency times, standing times and walking times in the MMKA and MMKY groups were significantly shorter than those in the MMK group. But there were not significantly different between MMKA and MMKY groups. In all groups, MMK administration produced a satisfactory sedation and analgesia for all dogs. However, after administration of atipamezole or yohimbine the scores for posture and response to noxious stimuli were significantly lower in the MMKA or MMKY group than those in the MMK group. MMK produced good sedation and anesthesia effects, and atipamezole or yohimbine can be used as a safe and effective agent for antagonizing the MMK anesthesia in dogs.

개에서 많은 주사용 마취제가 있고 그 부작용을 줄이기 위해 다양한 약물들을 혼합하여 사용한다. 개에서 medetomidine-midazolam-ketamine (MMK) 합제에 대한 마취효과를 알아보고, 이 합제에 대한 atipamezole과 yohimbine의 길항효과를 비교하였다. 18마리 수컷 비글견을 사용하였고, 모든 개에서 medetomidine (0.04 mg/kg), midazolam (0.2 mg/kg) 및 ketamine (5 mg/kg)을 근육주사하고, 20분 후 atipamezole (0.24 mg/kg, MMKA), yohimbine (0.2 mg/kg, MMKY) 또는 생리식염수(0.1 ml/kg, MMK)를 정맥주사하였다. 유도 및 회복시간, 진정 및 진통점수, 심박수, 혈압, 직장온도, 호흡수, 동맥혈액가스를 측정하였다. 평균마취, 흉와, 기립 및 보행시간은 MMKA와 MMKY군에서 MMK군보다 유의성있게 짧았다. 그러나 MMKA군과 MMKY군 간의 유의적인 차이는 없었다. 모든 군에서 MMK 투여는 개에서 만족스런 진정 및 진통을 일으켰다. 그러나 atipamezole이나 yohimbine 투여 후 자세점수 및 유해자극반응은 MMK군에 비해 MMKA나 MMKY군에서 유의성있게 감소하였다. 본 실험 결과 MMK는 양호한 진정 및 마취효과를 나타냈고, atipamezole과 yohimbine은 개에서 MMK 마취를 길항하는 데 안전하고 효과적으로 사용될 수 있을 것으로 사료된다.

Keywords

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