한국응용과학기술학회지 (Journal of the Korean Applied Science and Technology)

  • 제28권4호
  • /
  • Pages.438-448
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  • 2011
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  • 1225-9098(pISSN)
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  • 2288-1069(eISSN)
한국응용과학기술학회 (The Korean Society of Applied Science and Technology)
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키토산 C-6에 Amine기를 갖는 Polyamino Acid 유도체의 합성과 생물학적 활성에 관한 연구

A Study on the Synthesis and Biological Activity of Polyamino Acid Derivatives have Amine Group on to Chitosan C-6

  • 투고 : 2011.11.12
  • 심사 : 2011.12.06
  • 발행 : 2011.12.30
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초록

Chitosan is widely used in cosmetics and medical fields. Special emphasis has been put on the chemical modification of chitosan to explore its full potential. We have described the synthesis and biological activity of novel peptide amino acid derivatives. The polyamino acid derivatives were synthesized by introducing alkylamine functional group on chitosan at C-6. The poor aqueous solubility of chitosan derivatives hinder both pharmacological studies and pharmaceutical development. To make amino acid coupled chitosan derivatives with improved biological effect and solubility, some attempts have been taken to consist of amino peptide group like aspartic acid and phenylalanine-aspartic acid derivatives onto chitosan C-6. The resultingly substituted chitosan was characterized by solubility in various solvents. We measured chitosan derivatives with $^1H$-NMR and $^{13}C$-NMR. Also, We were investigated on the physical properties and biological activities of these products.

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참고문헌

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