Isolation of Compounds from Cimicifugae Rhizoma and their Cytotoxic Activity

  • Cuong, To Dao (College of Pharmacy, Catholic University of Daegu) ;
  • Lim, Chae-Jin (College of Pharmacy, Catholic University of Daegu) ;
  • Kim, Sang-Won (College of Pharmacy, Catholic University of Daegu) ;
  • Park, Ji-Eun (College of Pharmacy, Catholic University of Daegu) ;
  • Hung, Tran Manh (College of Pharmacy, Catholic University of Daegu) ;
  • Min, Byung-Sun (College of Pharmacy, Catholic University of Daegu)
  • Received : 2010.11.29
  • Accepted : 2011.04.30
  • Published : 2011.06.30

Abstract

Five known compounds, cimigenol (1), 25-O-acetylcimigenol (2), cimigenol 3-O-${\beta}$-D-xylopyranoside (3), ferulic acid methyl ester (4), and visnagin (5), were isolated from Cimicifugae Rhizoma (Ranunculaceae). The chemical structures of these compounds were determined on the basis of spectroscopic analyses including 2D NMR. Compounds 1 - 5 were evaluated for their cytotoxic activity against the HL-60, MCF-7, and A549 cancer cell lines in in vitro. Among them, compounds 4 and 5 showed moderate inhibitory activity against HL-60 cancer cell lines with $IC_{50}$ values of 24.8 and 18.1 ${\mu}M$, respectively.

Keywords

References

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