YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Antifungal Activity of Glycycoumarin to Candida albicans

Glycycoumarin 감초성분의 항진균효과

  • Lee, Jue-Hee (Department of ImmunoMicrobiology, College of Pharmacy, Dongduk Women's University) ;
  • Lee, Young-Mi (Department of ImmunoMicrobiology, College of Pharmacy, Dongduk Women's University) ;
  • Han, Yong-Moon (Department of ImmunoMicrobiology, College of Pharmacy, Dongduk Women's University)
  • 이주희 (동덕여자대학교 약학대학 천연물미생물학과) ;
  • 이영미 (동덕여자대학교 약학대학 천연물미생물학과) ;
  • 한용문 (동덕여자대학교 약학대학 천연물미생물학과)
  • Received : 2011.04.25
  • Accepted : 2011.05.04
  • Published : 2011.06.30
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Abstract

Glycycoumarin, a 3-arylcoumarine isolated from Glycyrrhizae radix (a family of Leguminosae), is reported to have anti-bacterial activity. However, its antifungal activity is still unknown. In this present study, the antifungal activity of glycycoumarin (GLM) against Candida albicans, a polymorphic fungus was investigated. Possible mechanism such as blocking of the hyphal induction was also analyzed. By the in-vitro susceptibility analysis, GLM showed anticandidal activity, resulting in an almost complete inhibition of the fungal growth at a concentration of 320 ${\mu}g/ml$, which was equivalent to the efficacy of fluconazole at the same dose. In the murine model of disseminated candidiasis GLM enhanced resistance of mice against the disseminated disease (P<0.05), resulting in 60% protection of GLM-treated mice group during a period of 21-day observation. As for its mechanism of the antifungal activity, GLM blocked hyphal production, one of the important of virulence factors by the fungus, from the yeast form of C. albicans (P<0.01). These data indicate that GLM may contribute to the perspectives that focus on the development of a novel agent with antifungal activity specific for C. albicans infection.

Keywords

References

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