References
- The Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR). American Psychiatric Association, Washington, DC (2000).
- Guze, S. and Robins, E. : Suicide and primary affective disorders. Br. J. Psychiatry 117, 437 (1970). https://doi.org/10.1192/bjp.117.539.437
- Murray, C. J. and Lopez, A. D. : Alternative projections of mortality and disability by cause 1990-2020: Global burden of disease study. Lancet 349, 1498 (1997). https://doi.org/10.1016/S0140-6736(96)07492-2
- Murthy, R., Bertolote, J., Epping-Jordan, J., Funk, M., Prentice, T., Saraceno, B. and Saxena, S. : The World Health report: 2001: Mental health: new understanding, new hope. World Health Organization, Geneva, Switzerland (2001).
- 이충경, 박강규, 조맹제, 정은기, 김장규, 김선욱 : 2006 정신질환실태 역학조사. 서울: 보건복지부 (2008).
- Sanders, A., Detera-Wadleigh, S. and Gershon, E. : Molecular genetics of mood disorders. Neurobiology of Mental Illness. New York, Oxford, 299 (1999).
- Akiskal, H. : Mood disorders: introduction and overview. Comprehensive Textbook of Psychiatry. 7th ed. Baltimore, MD: Lippincott Williams and Wilkins, 1284 (2000).
- Fava, M. and Kendler, K. S. : Major depressive disorder. Neuron 28, 335 (2000). https://doi.org/10.1016/S0896-6273(00)00112-4
- Hindmarch, I. : Expanding the horizons of depression: beyond the monoamine hypothesis. Hum. Psychopharmacol. 16, 203 (2001). https://doi.org/10.1002/hup.288
- Edwards, J. : Selective serotonin reuptake inhibitors. Br. Med. J. 304, 1644 (1992). https://doi.org/10.1136/bmj.304.6843.1644
- Rang, H., Dale, M., Ritter, J. and Moore, P. : Pharmacology. 5th Edition. Edinburgh, Churchill Livingstone. for Noradrenalin system, p. 186 (2003).
- Gumnick, J. F. and Nemeroff, C. B. : Problems with currently available antidepressants. J. Clin. Psychiatry 61 Suppl 10, 5 (2000).
- Maze, M. and Tranquilli, W. : Alpha-2 adrenoceptor agonists: defining the role in clinical anesthesia. Anesthesiology 74, 581 (1991). https://doi.org/10.1097/00000542-199103000-00029
- Sherman, A., Gal, E. M., Fuller, R. W. and Molloy, B. B. : Effects of intraventricular p-chloroamphetamine and its analogues on cerebral 5-HT. Neuropharmacology 14, 733 (1975). https://doi.org/10.1016/0028-3908(75)90098-2
- Krogsgaard-Larsen, P., Liljefors, T. and Madsen, U. : Textbook of drug design and discovery. Taylor & Francis, London (2002).
- Andres, J. I., Alcazar, J., Alonso, J. M., Alvarez, R. M., Bakker, M. H., Biesmans, I., Cid, J. M., De Lucas, A. I., Fernandez, J., Font, L. M., Hens, K. A., Iturrino, L., Lenaerts, I., Martinez, S., Megens, A. A., Pastor, J., Vermote, P. C. and Steckler, T. : Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity. J. Med. Chem. 48, 2054 (2005). https://doi.org/10.1021/jm049619s
- Andres, J. I., Alcazar, J., Alonso, J. M., Alvarez, R. M., Cid, J. M., De Lucas, A. I., Fernandez, J., Martinez, S., Nieto, C., Pastor, J., Bakker, M. H., Biesmans, I., Heylen, L. I. and Megens, A. A. : Synthesis of 3a,4-dihydro-3H-[1]benzopyrano [4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha(2)-adrenoceptor antagonistic activities: a novel series of potential antidepressants. Bioorg. Med. Chem. Lett. 13, 2719 (2003). https://doi.org/10.1016/S0960-894X(03)00525-0
- Andres, J. I., Alcazar, J., Alonso, J. M., De Lucas, A. I., Iturrino, L., Biesmans, I. and Megens, A. A. : Synthesis of 7-amino-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole derivatives displaying combined alpha2-adrenoceptor antagonistic and 5-HT reuptake inhibiting activities. Bioorg. Med. Chem. 14, 4361 (2006). https://doi.org/10.1016/j.bmc.2006.02.043
- Pastor, J., Alcazar, J., Alvarez, R. M., Andres, J. I. Cid, J. M., De Lucas, A. I., Diaz, A., Fernandez, J., Font, L. M., Iturrino, L., Lafuente, C., Martinez, S., Bakker, M. H., Biesmans, I., Heylen, L. I. and Megens, A. A. : Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha2-adrenoceptor antagonistic activities. Part 2: Further exploration on the cinnamyl moiety. Bioorg. Med. Chem. Lett. 14, 2917 (2004). https://doi.org/10.1016/j.bmcl.2004.03.031
- Tripos, S. : Molecular modeling and QSAR software on CDRom (Ver. 7.3), Tripos Associates, Inc., 1699 S. Hanley Road, Suite 303, 63144 (2001).
- Vasan, A. and Raju, K. : Comparative analysis of Simulated Annealing, Simulated Quenching and Genetic Algorithms for optimal reservoir operation. Applied. Soft. Computing 9, 274 (2009). https://doi.org/10.1016/j.asoc.2007.09.002
- Soung, M., Lee, Y. and Sung, N. : 3D-QSARs of Herbicidal 2-N-Phenylisoindolin-1-one Analogues as a New Class of Potent Inhibitors of Protox. Bull. Kor. Che. Soc. 30, 613 (2009). https://doi.org/10.5012/bkcs.2009.30.3.613
- Clark, M. and Cramer, R. : Comparative molecular field analysis (CoMFA). 2. Toward its use with 3D-structural databases. Tetrahedron Computer Methodology 3, 47 (1990). https://doi.org/10.1016/0898-5529(90)90120-W
- Marshall, G., Barry, C., Bosshard, H., Dammkoehler, R. and Dunn, D. : The conformational parameter in drug design: the active analog approach. In Computer-assisted Drug Design 112, 205 (1979).
- Cramer III, R., Bunce, J., Patterson, D. and Frank, I. : Crossvalidation, bootstrapping, and partial least squares compared with multiple regression in conventional QSAR studies. Quant. Struct.-Act. Relat. 7, 18 (1988). https://doi.org/10.1002/qsar.19880070105
- Lindberg, W., Persson, J. and Wold, S. : Partial least-squares method for spectrofluorimetric analysis of mixtures of humic acid and lignin sulfonate. Analytical Chemistry 55, 643 (1983). https://doi.org/10.1021/ac00255a014
- Beyer, C. E., Lin, Q., Rosenzweig-Lipson, S. and Schechter, L. E. : Alpha 2A-adrenoceptors enhance the serotonergic effects of fluoxetine. Eur. J. Pharmacol. 539, 164 (2006). https://doi.org/10.1016/j.ejphar.2006.03.083
- Blier, P. : Pharmacology of rapid-onset antidepressant treatment strategies. J. Clin. Psychiatry 62 Suppl 15, 12 (2001). https://doi.org/10.4088/JCP.v62n0104