Genomics & Informatics

Korea Genome Organization (한국유전체학회)
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Lack of Replication of Genetic Association with Body Mass Index Detected by Genome-wide Association Study

  • Lee, Hae-In (Asan Institute for Life Sciences, University of Ulsan College of Medicine) ;
  • Kim, Jae-Jung (Asan Institute for Life Sciences, University of Ulsan College of Medicine) ;
  • Park, Tae-Sung (Department of Statistics, College of Natural Science, Seoul National University) ;
  • Kim, Kyung-A (Department of Statistics, Sookmyung Women's University) ;
  • Lee, Jong-Eun (DNA Link) ;
  • Cho, Yoon-Shin (Center for Genome Science, National Institute of Health) ;
  • Lee, Jong-Young (Center for Genome Science, National Institute of Health) ;
  • Han, Bok-Ghee (Center for Genome Science, National Institute of Health) ;
  • Lee, Jong-Keuk (Asan Institute for Life Sciences, University of Ulsan College of Medicine)
  • Accepted : 2010.12.18
  • Published : 2011.06.30
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Abstract

Obesity provokes many serious human diseases, including various cardiovascular diseases and diabetes. Body mass index (BMI) is a highly heritable trait that is broadly used to diagnose obesity. To identify genetic loci associated with obesity in Asians, we conducted a genome-wide association study (GWAS) of a population of Korean adults (n=6,742, age 40~60 years) and detected six BMI risk loci (TNR, FAM124B, RGS12, NFE2L3, MC4R and FTO) having p< $1{\times}10^{-5}$. However, in the replication study, only melanocortin 4 receptor gene (MC4R) (rs9946888, p=$4.58{\times}10^{-7}$) was replicated with marginal significance (p<0.05) in the second cohort (n=5,102, age 40~60 years). This study indicates that each locus associated with BMI has very weak genetic effect.

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References

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