Journal of Haehwa Medicine (혜화의학회지)

Research Institute of Korean Medicine (대전대학교 한의학연구소)
권호 표지

Effect of Hyunggaeyunkyotangbalhyobang (HYBH) on Atopic Dermatitis in NC/Nga Mice Model

형개련교탕발효방(荊芥連翹湯醱酵方)이 NC/Nga mouse 동물병태에 미치는 영향

  • Park, Eung-Ho (Department of Pathology, College of Oriental Medicine, Daejeon University) ;
  • Yoo, Ji-Hyun (Department of Pathology, College of Oriental Medicine, Daejeon University) ;
  • Gim, Seon-Bin (Department of Pathology, College of Oriental Medicine, Daejeon University) ;
  • Lee, Yong-Koo (Department of Internal Medicine, Hyehwa Hospital, Daejeon University) ;
  • Kim, Dong-Hee (Department of Pathology, College of Oriental Medicine, Daejeon University)
  • Received : 2011.01.10
  • Accepted : 2011.02.08
  • Published : 2011.02.20
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Abstract

Various related factors and tissue changes in vitro and in vivo were observed to investigate the efficacy of HYBH on atopic dermatitis. The results are described below. HYBH improved the atopic dermatitis symptoms by naked eye examination, and significantly decreased dermatitis clinical index at 14 weeks. HYBH significantly decreased CD4+/CD45+, CD4+, CD8+, CD3+/CD69+ immune cell ratios in PBMC by 28%, 16%, 30%, 26% and 22% respectively. HYBH significantly decreased CD11b+/Gr-1+, CD3 immune cell ratios in dorsal skin by 35.3% and 67.5% respectively. HYBH significantly decreased the expression of IL-4 and IFN-${\gamma}$ in spleen by 23% and 15% respectively. HYBH significantly decreased the production rate of IL-5, IL-13 and histamine in serum by 17%, 23%, and 8.8% respectively and increased IL-17 production by 17%. HYBH significantly decreased immunoglubulins IgG1 and IgE production in serum. The results above indicated that treatment of HYBH improved atopic dermatitis symptoms by anti-oxidant activity and immune modulation activity as a clinical evidence. Also, different fermentation conditions using various microbial strains should be accumulated as the clinical evidence for broad application in the future.

Keywords

References

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