Archives of Plastic Surgery

  • 제38권6호
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  • Pages.733-739
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  • 2011
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  • 2234-6163(pISSN)
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  • 2234-6171(eISSN)
대한성형외과학회 (Korean Society of Plastic and Reconstructive Surgeons)
권호 표지

박테리아 유래 셀룰로오스가 백서의 창상치유에 미치는 영향

Wound Healing Effect of Bacterial Synthesized Cellulose on Full Thickness Skin Defect in the Rat

  • 박상욱 (대구가톨릭대학교 의과대학 성형외과학교실) ;
  • 이병권 (대구가톨릭대학교 의과대학 성형외과학교실) ;
  • 김미선 (대구가톨릭대학교 의과대학 성형외과학교실) ;
  • 박관규 (대구가톨릭대학교 의과대학 병리과학교실) ;
  • 성우정 (대구가톨릭대학교 의과대학 병리과학교실) ;
  • 김현연 (대구가톨릭대학교 의과대학 성형외과학교실) ;
  • 김찬우 (대구가톨릭대학교 의과대학 성형외과학교실) ;
  • 심정수 (대구가톨릭대학교 의과대학 성형외과학교실) ;
  • 이용직 (대구가톨릭대학교 의과대학 성형외과학교실) ;
  • 김성호 (대구대학교 식품공학과) ;
  • 김인호 (대구대학교 식품공학과) ;
  • 박대환 (대구가톨릭대학교 의과대학 성형외과학교실)
  • Park, Sang-Uk (Department of Plastic and Reconstructive Surgery, College of Medicine, Daegu Catholic University) ;
  • Lee, Byung-Kwon (Department of Plastic and Reconstructive Surgery, College of Medicine, Daegu Catholic University) ;
  • Kim, Mi-Sun (Department of Plastic and Reconstructive Surgery, College of Medicine, Daegu Catholic University) ;
  • Park, Kwan-Kyu (Department of Pathology, College of Medicine, Daegu Catholic University) ;
  • Sung, Woo-Jung (Department of Pathology, College of Medicine, Daegu Catholic University) ;
  • Kim, Hyun-Yeon (Department of Plastic and Reconstructive Surgery, College of Medicine, Daegu Catholic University) ;
  • Kim, Peter Chan-Woo (Department of Plastic and Reconstructive Surgery, College of Medicine, Daegu Catholic University) ;
  • Shim, Jeong-Su (Department of Plastic and Reconstructive Surgery, College of Medicine, Daegu Catholic University) ;
  • Lee, Yong-Jig (Department of Plastic and Reconstructive Surgery, College of Medicine, Daegu Catholic University) ;
  • Kim, Seong-Ho (Department of Food Science and Engineering, Daegu University) ;
  • Kim, In-Ho (Department of Food Science and Engineering, Daegu University) ;
  • Park, Dae-Hwan (Department of Plastic and Reconstructive Surgery, College of Medicine, Daegu Catholic University)
  • 투고 : 2011.09.03
  • 심사 : 2011.10.12
  • 발행 : 2011.11.10
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초록

Purpose: Cellulose is a natural substance from plants or bacteria. It is known that bacterial synthesized cellulose has an effect of wound healing. The aim of this study is to show the effect of bacterial synthesized cellulose from citrus on wound healing. Methods: Three full-thickness skin defects were made on the back of Sprague-Dawley rats. Three wounds were treated by vaseline gauze (Group V), Algisite $M^{(R)}$ (Group A) and bacterial synthesized cellulose from citrus (Group C) was used for dressing on skin defect on rats. We analyzed the gross, histological and biochemistry finding. Results: Group C showed more decrease of wound size compared to Group V (33% versus 7.2%) after 14 days. The histologic findings revealed Group C and Group A preceed the process of wound healing rather than Group V (More rapid collagen deposition and neovascularization and reduced inflammation). Also, the expressions of vascular endothelial growth factor (VEGF) and transforming growth factor (TGF)-${\beta}1$ were increased in the Group C and Group A compared with the Group V in 7 days. VEGF and TGF-${\beta}1$ expression were decreased in the Group C and Group A in 14 days, however Group V was not decreased at 14 day because of delayed wound healing process. Conclusion: Bacterial synthesized cellulose from citrus affects wound healing by reducing the inflammatory stage. And stimulates wound contracture by the deposition of extracellular matrix, thus preventing the formation of chronic wounds.

키워드

참고문헌

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