Multidrug-Resistant Streptococcus pneumoniae Sepsis and Meningitis after Craniofacial Surgery: Case Report

두개안면부 수술 후 발생한 다약제내성폐렴구균패혈증및뇌막염: 증례보고

  • Kim, Hyung-Suk (Samsung Medical Center, Department of Plastic Surgery, Sungkyunkwan University School of Medicine) ;
  • Lim, So-Young (Samsung Medical Center, Department of Plastic Surgery, Sungkyunkwan University School of Medicine) ;
  • Pyon, Jai-Kyong (Samsung Medical Center, Department of Plastic Surgery, Sungkyunkwan University School of Medicine) ;
  • Mun, Goo-Hyun (Samsung Medical Center, Department of Plastic Surgery, Sungkyunkwan University School of Medicine) ;
  • Bang, Sa-Ik (Samsung Medical Center, Department of Plastic Surgery, Sungkyunkwan University School of Medicine) ;
  • Oh, Kap-Sung (Samsung Medical Center, Department of Plastic Surgery, Sungkyunkwan University School of Medicine)
  • 김형석 (성균관대학교 의과대학 성형외과학교실) ;
  • 임소영 (성균관대학교 의과대학 성형외과학교실) ;
  • 변재경 (성균관대학교 의과대학 성형외과학교실) ;
  • 문구현 (성균관대학교 의과대학 성형외과학교실) ;
  • 방사익 (성균관대학교 의과대학 성형외과학교실) ;
  • 오갑성 (성균관대학교 의과대학 성형외과학교실)
  • Received : 2011.04.03
  • Accepted : 2011.05.23
  • Published : 2011.07.10

Abstract

Purpose: The prevalence of antibiotic-resistant Streptococcus pneumoniae meningitis has increased worldwide. There are some reports about postoperative antibiotic-resistant Streptococcus pneumoniae infection after craniofacial surgery, but, there is no report in Korea. We present a report on the treatment of postoperative multidrug-resistant Streptococcus pneumoniae (MRSP) meningitis and sepsis after craniofacial surgery based on our experience. Methods: The patient was a 7-year-old boy with Crouzon's disease who was treated by fronto-orbital bar advancement. Intraoperatively, frontal sinus opening was seen during osteotomy which was covered with forehead galeopericranial flap. MRSP meningitis was diagnosed after the surgery, he was treated with intravenous vancomycin, meropenem, and levofloxacin. Results: The patient was treated successfully after 3 weeks of intravenous antibiotics treatment. During the 8 month follow-up period, there was no neurologic sequelae. Conclusion: Postoperative infection after craniofacial surgery is an important phenomenon that needs immediate recognition. Prevention, early diagnosis, and treatment immediate after onset are important as countermeasures against postoperative drug-resistant bacterial infection. To prevent adverse outcome and reoperation, proper antibiotics treatment should be performed.

Keywords

References

  1. Song JH, Jung SI, Ko KS, Kim NY, Son JS, Chang HH, Ki HK, Oh WS, Suh JY, Peck KR, Lee NY, Yang Y, Lu Q, Chongthaleong A, Chiu CH, Lalitha MK, Perera J, Yee TT, Kumarasinghe G, Jamal F, Kamarulzaman A, Parasakthi N, Van PH, Carlos C, So T, Ng TK, Shibl A: High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study). Antimicrob Agents Chemother 48: 2101, 2004 https://doi.org/10.1128/AAC.48.6.2101-2107.2004
  2. Dashti SR, Baharvahdat H, Spetzler RF, Sauvageau E, Chang SW, Stiefel MF, Park MS, Bambakidis NC: Operative intracranial infection following craniotomy. Neurosurg Focus 24: E10, 2008
  3. Watanabe Y, Akizuki, T: Prevention and treatment of penicillin-resistant Streptococcus pneumoniae meningitis after intracraniofacial surgery with distraction osteogenesis. J Craniofac Surg 19: 1542, 2008 https://doi.org/10.1097/SCS.0b013e31818eece4
  4. Lynch JP 3rd, Zhanel GG: Streptococcus pneumoniae: epidemiology, risk factors, and strategies for prevention. Semin Respir Crit Care Med 30: 189, 2009 https://doi.org/10.1055/s-0029-1202938
  5. Lynch JP 3rd, Zhanel GG: Streptococcus pneumoniae: does antimicrobial resistance matter? Semin Respir Crit Care Med 30: 210, 2009 https://doi.org/10.1055/s-0029-1202939
  6. Lee Y, Kim, WJ: How to make the blockage between the nasal cavity and intracranial space using a four-layer sealing technique. Plast Reconstr Surg 117: 233, 2006 https://doi.org/10.1097/01.prs.0000187141.52610.1f
  7. Whitney CG, Farley MM, Hadler J, Harrison LH, Bennett NM, Lynfield R, Reingold A, Cieslak PR, Pilishvili T, Jackson D, Facklam RR, Jorgensen JH, Schuchat A: Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine. N Engl J Med 348: 1737, 2003 https://doi.org/10.1056/NEJMoa022823
  8. Tunkel AR, Hartman BJ, Kaplan SL, Kaufman BA, Roos KL, Scheld WM, Whitley RJ: Practice guidelines for the management of bacterial meningitis. Clin Infect Dis 39: 1267, 2004. https://doi.org/10.1086/425368