Botulinum Toxin A Treatment for Cervical Dystonia Resulting in Endoscopic Thyroidectomy: A Case Report

내시경 갑상샘 절제술 후 발생한 경부 근긴장이상증의 보툴리늄 A 독소를 이용한 치료: 증례보고

  • Oh, Hwa-Young (Department of Plastic and Reconstructive Surgery, College of Medicine, Soonchunhyang University) ;
  • Choi, Hwan-Jun (Department of Plastic and Reconstructive Surgery, College of Medicine, Soonchunhyang University) ;
  • Nam, Doo-Hyun (Department of Plastic and Reconstructive Surgery, College of Medicine, Soonchunhyang University) ;
  • Kim, Jun-Hyuk (Department of Plastic and Reconstructive Surgery, College of Medicine, Soonchunhyang University) ;
  • Lee, Young-Man (Department of Plastic and Reconstructive Surgery, College of Medicine, Soonchunhyang University)
  • 오화영 (순천향대학교 의과대학 성형외과학교실) ;
  • 최환준 (순천향대학교 의과대학 성형외과학교실) ;
  • 남두현 (순천향대학교 의과대학 성형외과학교실) ;
  • 김준혁 (순천향대학교 의과대학 성형외과학교실) ;
  • 이영만 (순천향대학교 의과대학 성형외과학교실)
  • Received : 2010.09.07
  • Accepted : 2010.11.17
  • Published : 2011.03.10

Abstract

Purpose: Surgery for thyroid gland requires skin incisions that can result in postsurgical neck scar. To overcome this, many surgeons performed a endoscopic thyroidectomy. But, this approach had a some problems. One of postoperative problems, iatrogenic cervical dystonia (CD) may occur. At common, CD is defined as a syndrome characterized by prolonged muscle contraction causing twisting, repetitive movements or abnormal posture. Botulinum toxin A (BTA, Botox$^{(R)}$, Allergan, Irvine, CA, USA) is well known treatment agent in the treatment of CD. So, the authors applied BTA injection in rare case with iatrogenic CD resulting in endoscopic thyroidectomy. Methods: A 43-year-old female had endoscopic subtotal thyroidectomy operation 3 years ago. She had symptoms such as progressive cervical pain, abnormal neck posture, depression, and sleep difficulty. About 1 year later, the patient who had previous myomectomy of the clavicular head of sternocleidomastoid muscle, however, symptoms were not improved. And then the patient received BTA therapy in our department. The 2 units per 0.1 mL solution was administered in a 1 mL tuberculin syringe. Results: The dose of BTA used in the patient was 36 units for vertical platysmal bands, superficially, and 10 units for ipsilateral sternocleidomastoid muscle, intramuscularly. After 2 weeks, additional the dose of BTA used in the patient was 5 points for remained scar bands, superficially. Complications related to injection such as significant swallowing difficulties, neck muscle weakness, or sensory change were not observed. In 9 months follow-up, the patient maintained a good result from the method of BTA injection alone. Conclusion: The basic concept is selective denervation for the hyperactive individual muscles and scar bands. We conclude that BTA is an effective and safe treatment for CD despite the iatrogenic and complex presentation of this complication.

Keywords

References

  1. Kim JH, Bae JS, Kim KH, Kim JI, Ahn CH, Park WC, Song BJ, Jung SS, Kim JS: A clinical application of gasless endoscopic thyroidectomy: clinical analysis of 300 cases at a single institution. J Korea Surg Soc 74: 330, 2008
  2. Kim SJ, Yoon JH, Chung WY, Nam KH, Park CH, Park CS: Gasless endoscopic thyroidectomy via an axillary approach. J Korea Surg Soc 70: 357, 2006
  3. Yim SY, Lee IY, Park MC, Kim JH: Differential diagnosis and management of abnormal posture of the head and neck. J Korean Med Assoc 52: 705, 2009 https://doi.org/10.5124/jkma.2009.52.7.705
  4. Son BC, Kim MC, Lee KS, Park CK, Kang JK: Botulinum toxin A for spasmodic torticollis, hemifacial spasm and facial synkinesis. J Korean Neurosurg Soc 31: 600, 2002
  5. Kim DY, Jeon SR, Chang UK, Kim HJ: Effects and complications of the upper cervical rhizotomy in spasmodic torticollis. J Korean Neurosurg Soc 27: 172, 1998
  6. Wie BA, Lee KW, Roh JK, Lee SB, Myung HJ: Injection site and doses in the treatment of cervical dystonia with botulinum A toxin: a preliminary report. J Korean Neurol Assoc 9: 341, 1991
  7. Lee MS, Sohn YH, Kim JS: Botulinum toxin treatment in the patients with spasmodic torticollis. J Korean Neurol Assoc 15: 790, 1997
  8. Joh SH: Application of botulinum toxin injection in plastic surgery. J Korean Soc Plast Reconstr Surg 30: 164, 2003