Journal of Gastric Cancer

The Korean Gastric Cancer Association (대한위암학회)
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Clinicopathologic Characteristics of Gastric Cancer Patients according to the Timing of the Recurrence after Curative Surgery

  • Choi, Ji-Yoon (Department of Surgery, Hanyang University College of Medicine) ;
  • Ha, Tae-Kyung (Department of Surgery, Hanyang University College of Medicine) ;
  • Kwon, Sung-Joon (Department of Surgery, Hanyang University College of Medicine)
  • Received : 2010.09.24
  • Accepted : 2010.11.25
  • Published : 2011.03.31
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Abstract

Purpose: There are few studies that have focused on the predictors of recurrence after gastrectomy for gastric carcinoma. This study analyzed the patients who died of recurrent gastric carcinoma and we attempted to clarify the clinicopathologic factors that are associated with the timing of recurrence. Materials and Methods: From June 1992 to March 2009, 1,795 patients underwent curative gastric resection at the Department of Surgery, Hanyang University College of Medicine. Among them, 428 patients died and 311 of these patients who died of recurrent gastric carcinoma were enrolled in this study. The clinicopathologic findings were compared between the 72 patients who died within one year after curative gastrectomy (the early recurrence group) and the 92 patients who died 3 years after curative gastrectomy (the late recurrence group). Results: Compared with the late recurrence group, the early recurrence group showed an older age, a more advanced stage, a poorly differentiated type of cancer and a significantly higher tendency to have lymphatic invasion, vascular invasion and perineural invasion.Especially in the gastric cancer patients with a more advanced stage (stage III and IV), the early recurrence group was characterized by a significantly higher preoperative serum carcino embryonic antigen level, perineural invasion and a relatively small number of dissected lymph nodes. Conclusions: The clinicopathologic characteristics of recurrent gastric cancer are significantly different according to the stage of disease, and even in the same stage. For the early detection of recurrence after curative surgery, it is important to recognize the clinicopathological factors that foretell a high risk of recurrence. It is mandatory to make an individualized surveillance schedule according to the clinicopathologic factors.

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References

  1. Huh H, Hyung WJ, Chen J, Choi SH, Noh SH. Implication of lymphatic or blood vessel invasion in early gastric cancer. J Korean Surg Soc 2003;64:134-139.
  2. Liu C, Zhang R, Lu Y, Li H, Lu P, Yao F, et al. Prognostic role of lymphatic vessel invasion in early gastric cancer: a retrospective study of 188 cases. Surg Oncol 2010;19:4-10. https://doi.org/10.1016/j.suronc.2008.10.003
  3. Kim CD, Chang MC, Roh HR, Chae GB, Yang DH, Choi WJ. Factors influencing recurrence after curative resection for advanced gastric cancer. J Korean Surg Soc 2003;65:301-308.
  4. Kim HI, Kim CS, Kim SJ, Mok YJ, Park SS. Risk factors of the recurrence after a curative resection of gastric carcinoma invading the muscularis propria. J Korean Surg Soc 2006;70:98-101.
  5. Shin DW, Hyung WJ, Noh SH, Min JS. Risk factors for recurrence after curative surgery for early gastric cancer. J Korean Gastric Cancer Assoc 2001;1:106-112.
  6. Sakar B, Karagol H, Gumus M, Basaran M, Kaytan E, Argon A, et al. Timing of death from tumor recurrence after curative gastrectomy for gastric cancer. Am J Clin Oncol 2004;27:205-209. https://doi.org/10.1097/01.coc.0000092703.12189.a2
  7. Kim W, Park CH, Park SM, Park WB, Lim KW, Kim SN. Prognostic significance of lymphatic and perineural invasions in patients with gastric cancer who have no lymph node and serosal involvement. J. Korean Gastric Cancer Assoc 2001;1:77-82.
  8. Baik SH, Yang SI, Shin YM. Clinicopathological analysis of recurrence in stage 1 gastric cancer. J Korean Surg Soc 2010;79:35-42. https://doi.org/10.4174/jkss.2010.79.1.35
  9. Park KJ, Park JG, Kim JP. Clinical analysis on recurrence pattern of gastric cancer. J Korean Cancer Assoc 1990;22:556-566.
  10. Lai JF, Kim S, Kim K, Li C, Oh SJ, Hyung WJ, et al. Prediction of recurrence of early gastric cancer after curative resection. Ann Surg Oncol 2009;16:1896-1902. https://doi.org/10.1245/s10434-009-0473-x
  11. Shiraishi N, Inomata M, Osawa N, Yasuda K, Adachi Y, Kitano S. Early and late recurrence after gastrectomy for gastric carcinoma. Univariate and multivariate analyses. Cancer 2000;89:255-261. https://doi.org/10.1002/1097-0142(20000715)89:2<255::AID-CNCR8>3.0.CO;2-N
  12. Sun Z, Li DM, Wang ZN, Huang BJ, Xu Y, Li K, et al. Prognostic significance of microscopic positive margins for gastric cancer patients with potentially curative resection. Ann Surg Oncol 2009;16:3028-3037. https://doi.org/10.1245/s10434-009-0624-0
  13. Ogata K, Mochiki E, Yanai M, Toyomasu Y, Ando H, Ohno T, et al. Factors correlated with early and late recurrence after curative gastrectomy for gastric cancer. Hepatogastroenterology 2009;56:1760-1764.
  14. Yokota T, Saito T, Teshima S, Yamada Y, Iwamoto K, Takahashi M, et al. Early and late recurrences after gastrectomy for gastric cancer: a multiple logistic regression analysis. Ups J Med Sci 2002;107:17-22. https://doi.org/10.3109/2000-1967-138
  15. Choi HS, Park SH, Kim JH. Factors predicting timing of recurrence after radical gastrectomy for gastric carcinoma. J Korean Surg Soc 2003;65:515-521.
  16. Cho JN, Kim YH. Clinicopathologic evaluation of patients with recurrence of gastric cancer within 6 months after curative resection. J Korean Surg Soc 2009;77:385-390. https://doi.org/10.4174/jkss.2009.77.6.385
  17. Kim JW, Hwang I, Kim MJ, Jang SJ. Clinicopathological characteristics and predictive markers of early gastric cancer with recurrence. J Korean Med Sci 2009;24:1158-1164. https://doi.org/10.3346/jkms.2009.24.6.1158
  18. Bilici A, Seker M, Ustaalioglu BB, Kefeli U, Yildirim E, Yavuzer D, et al. Prognostic significance of perineural invasion in patients with gastric cancer who underwent curative resection. Ann Surg Oncol 2010;17:2037-2044. https://doi.org/10.1245/s10434-010-1027-y
  19. Tanaka A, Watanabe T, Okuno K, Yasutomi M. Perineural invasion as a predictor of recurrence of gastric cancer. Cancer 1994;73:550-555. https://doi.org/10.1002/1097-0142(19940201)73:3<550::AID-CNCR2820730309>3.0.CO;2-0
  20. Kim W, Park CH, Park SM, Park WB, Lim KW, Kim SN. Prognostic significance of lymphatic and perineural invasions in patients with gastric cancer who have no lymph node and serosal involvement. J Korean Gastric Cancer Assoc 2001;1:77-82.
  21. Villarreal-Garza C, Rojas-Flores M, Castro-Sanchez A, Villa AR, Garcia-Aceituno L, Leon-Rodriguez E. Improved outcome in asymptomatic recurrence following curative surgery for gastric cancer. Med Oncol 2010. [Epub ahead of print]
  22. Dikken JL, Jansen EP, Cats A, Bakker B, Hartgrink HH, Kranenbarg EM, et al. Impact of the extent of surgery and postoperative chemoradiotherapy on recurrence patterns in gastric cancer. J Clin Oncol 2010;28:2430-2436. https://doi.org/10.1200/JCO.2009.26.9654
  23. Buzzoni R, Bajetta E, Di Bartolomeo M, Miceli R, Beretta E, Ferrario E, et al. Pathological features as predictors of recurrence after radical resection of gastric cancer. Br J Surg 2006;93:205-209. https://doi.org/10.1002/bjs.5225
  24. de Manzoni G, Pedrazzani C, Pasini F, Durante E, Gabbani M, Grandinetti A, et al. Pattern of recurrence after surgery in adenocarcinoma of the gastro-oesophageal junction. Eur J Surg Oncol 2003;29:506-510. https://doi.org/10.1016/S0748-7983(03)00098-2
  25. Lee HJ, Kim YH, Kim WH, Lee KU, Choe KJ, Kim JP, et al. Clinicopathological analysis for recurrence of early gastric cancer. Jpn J Clin Oncol 2003;33:209-214. https://doi.org/10.1093/jjco/hyg042
  26. Ha TK, Kwon SJ. Clinicopathologic characteristics according to the type of recurrence in curatively-resected gastric cancer patients. J Korean Gastric Cancer Assoc 2007;7:23-30.
  27. Mikami K, Maekawa T, Shinohara T, Hoshino S, Yamauchi Y, Noritomi T, et al. Predictive factors of early recurrent death after a curative resection of gastric cancer. Int Surg 2009;94:144-148.
  28. Kim JM, Kwon OJ, Kwon SJ, Shin DI, Park CD, Lee KS, et al. Remnant gastric cancer. J Korean Surg Soc 1997;52:520-528.
  29. Baik SH, Yang SI, Shin YM. Clinicopathological analysis of recurrence in stage 1 gastric cancer. J Korean Surg Soc 2010;79:35-42. https://doi.org/10.4174/jkss.2010.79.1.35
  30. Nashimoto A, Yabusaki H, Nakagawa S. Proper follow-up schedule after curative gastric surgery. Gan To Kagaku Ryoho 2009;36:1402-1407.

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