Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
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Association of Body Mass Index with Oral Cancer Risk

  • Choi, Sung-Weon (Oral Oncology Clinic, Research Institute and Hospital, National Cancer Center) ;
  • Lee, Jong-Ho (Department of Oral and Maxillofacial Surgery and Dental Research Institute, College of Dentistry, Seoul National University) ;
  • Park, Joo-Yong (Oral Oncology Clinic, Research Institute and Hospital, National Cancer Center) ;
  • Yun, Young-Mi (Cancer Epidemiology Branch, Research Institute and Hospital, National Cancer Center) ;
  • Kim, Mi-Kyung (Cancer Epidemiology Branch, Research Institute and Hospital, National Cancer Center)
  • Received : 2011.07.01
  • Accepted : 2011.09.01
  • Published : 2011.11.30
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Abstract

Purpose: Although obesity is a well-established risk factor for many cancers, the effect of body mass index (BMI) on oral cancer risk remains controversial. We therefore investigated the effect of BMI on oral cancer risk in a case-control study in Korea. Methods: Overall, 364 patients with oral cancer and 439 community controls were enrolled. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models, adjusted for age, smoking status and alcohol consumption. Results: We found no overall significant evidence of an association between oral cancer risk and BMI in either gender. However, when the relationship between BMI and oral cancer risk was examined according to female age groups (<50 and ${\geq}$50 years), there was a significant association between oral cancer risk and high BMI in female subjects younger than 50 years of age (OR=3.92, 95% CI 1.03~14.9, $P$ for trend=0.04), but not in older (${\geq}$50 years) female subjects (OR=1.11, 95% CI 0.55~2.24, $P$ for trend=0.76). There was no significant relationship between BMI and oral cancer risk in any of the male age subgroups. Conclusion: Our study provides the first epidemiological evidence supporting an association between obesity and an increased risk of oral cancer.

Keywords

References

  1. Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003;348:1625-38. https://doi.org/10.1056/NEJMoa021423
  2. Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath CW Jr. Body-mass index and mortality in a prospective cohort of U.S. adults. N Engl J Med 1999;341:1097-105. https://doi.org/10.1056/NEJM199910073411501
  3. Gu D, He J, Duan X, et al. Body weight and mortality among men and women in China. JAMA 2006;295:776-83. https://doi.org/10.1001/jama.295.7.776
  4. Jee SH, Sull JW, Park J, et al. Body-mass index and mortality in Korean men and women. N Engl J Med 2006;355:779-87. https://doi.org/10.1056/NEJMoa054017
  5. American Institute for Cancer Research and World Cancer Research Fund. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Washington, DC: 2007.
  6. IARC (2002). Handbooks of cancer prevention, Vol. 6. Weight control and physical activity. Lyon: IARC Press.
  7. Franceschi S, Maso D, Levi F, et al. Leanness as early marker of cancer of the oral cavity and pharynx. Ann Oncol 2001;12:331-6. https://doi.org/10.1023/A:1011191809335
  8. Rajkumar T, Sridhar H, Balaram P, et al. Oral cancer in Southern India: the influence of body size, diet, infections and sexual practices. Eur J Cancer Prev 2003;12:135-43. https://doi.org/10.1097/00008469-200304000-00007
  9. Hashibe M, Sankaranarayanan R, Thomas G, et al. Alcohol drinking, body mass index and the risk of oral leukoplakia in an Indian population. Int J Cancer 2000;88:129-34. https://doi.org/10.1002/1097-0215(20001001)88:1<129::AID-IJC20>3.0.CO;2-U
  10. Hashibe M, Sankaranarayanan R, Thomas G, et al. Body mass index, tobacco chewing, alcohol drinking and the risk of oral submucous fibrosis in Kerala, India. Cancer Causes Control 2002;13:55-64. https://doi.org/10.1023/A:1013991025848
  11. Thomas G, Hashibe M, Jacob BJ, et al. Risk factors for multiple oral premalignant lesions. Int J Cancer 2003;107:285-91. https://doi.org/10.1002/ijc.11383
  12. Shiboski CH, Shiboski SC, Silverman S Jr. Trends in oral cancer rates in the United States, 1973-1996. Community Dent Oral Epidemiol 2000;28:249-56. https://doi.org/10.1034/j.1600-0528.2000.280402.x
  13. Choi SY, Kahyo H. Effect of cigarette smoking and alcohol consumption in the aetiology of cancer of the oral cavity, pharynx and larynx. Int J Epidemiol 1991;20:878-85. https://doi.org/10.1093/ije/20.4.878
  14. Mignogna MD, Fedele S, Lo Russo L. The world cancer report and the burden of oral cancer. Eur J Cancer Prev 2004;13:139-42.
  15. Znaor A, Brennan P, Gajalakshmi V, et al. Independent and combined effects of tobacco smoking, chewing and alcohol drinking on the risk of oral, pharyngeal and esophageal cancers in Indian men. Int J Cancer 2003;105:681-6. https://doi.org/10.1002/ijc.11114
  16. IARC. World Cancer Report. Lyon: IARC Press; 2003.
  17. Blot WJ, McLaughlin JK, Winn DM, et al. Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Res 1988;48:3282-7.
  18. Balaram P, Sridhar H, Rajkumar T, et al. Oral cancer in southern India: the influence of smoking, drinking, paanchewing and oral hygiene. Int J Cancer 2002;98:440-5. https://doi.org/10.1002/ijc.10200
  19. Anaya-Saavedra G, Ramirez-Amador V, Irigoyen-Camacho ME, et al. High association of human papillomavirus infection with oral cancer: a case-control study. Arch Med Res 2008;39:189-97. https://doi.org/10.1016/j.arcmed.2007.08.003
  20. Chaturvedi AK, Engels EA, Anderson WF, Gillison ML. Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States. J Clin Oncol 2008;26:612-9. https://doi.org/10.1200/JCO.2007.14.1713
  21. Harty LC, Caporaso NE, Hayes RB, et al. Alcohol dehydrogenase 3 genotype and risk of oral cavity and pharyngeal cancers. J Natl Cancer Inst 1997;89:1698-705. https://doi.org/10.1093/jnci/89.22.1698
  22. Kreimer AR, Randi G, Herrero R, Castellsague X, La Vecchia C, Franceschi S; IARC Multicenter Oral Cancer Study Group. Diet and body mass, and oral and oropharyngeal squamous cell carcinomas: analysis from the IARC multinational case-control study. Int J Cancer 2006;118:2293-7. https://doi.org/10.1002/ijc.21577
  23. Yang H, Lippman SM, Huang M, et al. Genetic polymorphisms in double-strand break DNA repair genes associated with risk of oral premalignant lesions. Eur J Cancer 2008;44:1603-11. https://doi.org/10.1016/j.ejca.2008.05.006
  24. Zheng T, Boyle P, Willett WC, et al. A case-control study of oral cancer in Beijing, People's Republic of China. Associations with nutrient intakes, foods and food groups. Eur J Cancer B Oral Oncol 1993;29B:45-55.
  25. The World Health Organization Western Pacific Region. The International Association for the Study of Obesity, and The International Obesity Task Force. The Asia-Pacific Perspective: redefining obesity and its treatment. ed. Syndey, Australia: Health Communications Australia Pty Limited, 2000.
  26. Hosmer DW, Lemeshow S. Applied logistic regression. New York, NY: John Wiley and Sons; 2000.
  27. Ministry of Health and Welfare. Report on 2005 National Health and Nutrition Survey, 2008.
  28. Korea Central Cancer Registry. Cancer incidence in Korea (1999-2002). Ministry for Health, Welfare and Family Affairs, 2006.
  29. Kuriyama S, Tsubono Y, Hozawa A, et al. Obesity and risk of cancer in Japan. Int J Cancer 2005;113:148-57. https://doi.org/10.1002/ijc.20529
  30. Oh SW, Yoon YS, Shin SA. Effects of excess weight on cancer incidences depending on cancer sites and histologic findings among men: Korea National Health Insurance Corporation Study. J Clin Oncol 2005;23:4742-54. https://doi.org/10.1200/JCO.2005.11.726
  31. Pan SY, Johnson KC, Ugnat AM, Wen SW, Mao Y; Canadian Cancer Registries Epidemiology Research Group. Association of obesity and cancer risk in Canada. Am J Epidemiol 2004;159:259-68. https://doi.org/10.1093/aje/kwh041
  32. Sauvaget C, Ramadas K, Thomas G, Vinoda J, Thara S, Sankaranarayanan R. Body mass index, weight change and mortality risk in a prospective study in India. Int J Epidemiol 2008;37:990-1004. https://doi.org/10.1093/ije/dyn059
  33. D'Avanzo B, La Vecchia C, Talamini R, Franceschi S. Anthropometric measures and risk of cancers of the upper digestive and respiratory tract. Nutr Cancer 1996;26:219-27. https://doi.org/10.1080/01635589609514478
  34. Kabat GC, Chang CJ, Wynder EL. The role of tobacco, alcohol use, and body mass index in oral and pharyngeal cancer. Int J Epidemiol 1994;23:1137-44. https://doi.org/10.1093/ije/23.6.1137
  35. Nieto A, Sanchez MJ, Martinez C, et al. Lifetime body mass index and risk of oral cavity and oropharyngeal cancer by smoking and drinking habits. Br J Cancer 2003;89:1667-71. https://doi.org/10.1038/sj.bjc.6601347
  36. Hashibe M, Jacob BJ, Thomas G, et al. Socioeconomic status, lifestyle factors and oral premalignant lesions. Oral Oncol 2003;39:664-71. https://doi.org/10.1016/S1368-8375(03)00074-5
  37. Huot I, Paradis G, Ledoux M; Quebec Heart Health Demonstration Project research group. Factors associated with overweight and obesity in Quebec adults. Int J Obes Relat Metab Disord 2004;28:766-74. https://doi.org/10.1038/sj.ijo.0802633
  38. Molarius A, Seidell JC, Kuulasmaa K, Dobson AJ, Sans S. Smoking and relative body weight: an international perspective from the WHO MONICA Project. J Epidemiol Community Health 1997;51:252-60. https://doi.org/10.1136/jech.51.3.252
  39. Tsugane S, Sasaki S, Tsubono Y. Under- and overweight impact on mortality among middle-aged Japanese men and women: a 10-y follow-up of JPHC study cohort I. Int J Obes Relat Metab Disord 2002;26:529-37. https://doi.org/10.1038/sj.ijo.0801961
  40. Millar WJ. Distribution of body weight and height: comparison of estimates based on self-reported and observed measures. J Epidemiol Community Health 1986;40:319-23. https://doi.org/10.1136/jech.40.4.319