Clinical and Experimental Reproductive Medicine

  • 제38권3호
  • /
  • Pages.153-158
  • /
  • 2011
  • /
  • 2233-8233(pISSN)
  • /
  • 2233-8241(eISSN)
대한생식의학회 (The Korean Society for Reproductive Medicine)
권호 표지
DOI QR코드

DOI QR Code

Serum anti-M$\ddot{u}$llerian hormone levels as a predictor of the ovarian response and IVF outcomes

  • Choi, Min-Hye (Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine) ;
  • Yoo, Ji-Hee (Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine) ;
  • Kim, Hye-Ok (Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine) ;
  • Cha, Sun-Hwa (Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine) ;
  • Park, Chan-Woo (Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine) ;
  • Yang, Kwang-Moon (Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine) ;
  • Song, In-Ok (Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine) ;
  • Koong, Mi-Kyoung (Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine) ;
  • Kang, Inn-Soo (Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine)
  • 투고 : 2011.08.05
  • 심사 : 2011.09.16
  • 발행 : 2011.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objective: The aim of this study was to investigate whether anti-M$\ddot{u}$llerian hormone (AMH) levels could be predict ovarian poor/hyper response and IVF cycle outcome. Methods: Between May 2010 and January 2011, serum AMH levels were evaluated with retrospective analysis. Three hundred seventy infertile women undergoing 461 IVF cycles between the ages of 20 and 42 were studied. We defined the poor response as the number of oocytes retrieved was equal or less than 3, and the hyper response as more than 25 oocytes retrieved. Serum AMH was measured by commercial enzymelinked immunoassay. Results: The number of oocytes retrieved was more correlated with the serum AMH level (r=0.781, $p$ <0.01) than serum FSH (r=-0.412, $p$ <0.01). The cut-off value of serum AMH levels for poor response was 1.05 ng/mL (receiver operating characteristic [ROC] curves/area under the curve [AUC], $ROC_{AUC}$=0.85, sensitivity 74%, specificity 87%). Hyper response cut-off value was 3.55 ng/mL $ROC_{AUC}$=0.91, sensitivity 94%, specificity 81%). When the study group was divided according to the serum AMH levels (low: <1.05 ng/mL, middle: 1.05 ng/mL - 3.55 ng/mL, high: >3.55 ng/mL), the groups showed no statistical differences in mature oocyte rates (71.6% vs. 76.5% vs. 74.8%) or fertilization rates (76.9% vs. 76.6% vs. 73.8%), but showed significant differences in clinical pregnancy rates (21.7% vs. 24.1% vs. 40.8%, $p$=0.017). Conclusion: The serum AMH level can be used to predict the number of oocytes retrieved in patients, distinguishing poor and high responders.

키워드

참고문헌

  1. Kwee J, Elting MW, Schats R, Bezemer PD, Lambalk CB, Schoemaker J. Comparison of endocrine tests with respect to their predictive value on the outcome of ovarian hyperstimulation in IVF treatment: results of a prospective randomized study. Hum Reprod 2003;18:1422-7. https://doi.org/10.1093/humrep/deg205
  2. Gleicher N, Weghofer A, Barad DH. Defining ovarian reserve to better understand ovarian aging. Reprod Biol Endocrinol 2011;9:23. https://doi.org/10.1186/1477-7827-9-23
  3. Bukulmez O, Arici A. Assessment of ovarian reserve. Curr Opin Obstet Gynecol 2004;16:231-7. https://doi.org/10.1097/00001703-200406000-00005
  4. Sills ES, Alper MM, Walsh AP. Ovarian reserve screening in infertility: practical applications and theoretical directions for research. Eur J Obstet Gynecol Reprod Biol 2009;146:30-6. https://doi.org/10.1016/j.ejogrb.2009.05.008
  5. Al-Azemi M, Killick SR, Duffy S, Pye C, Refaat B, Hill N, et al. Multimarker assessment of ovarian reserve predicts oocyte yield after ovulation induction. Hum Reprod 2011;26:414-22. https://doi.org/10.1093/humrep/deq339
  6. La Marca A, Sighinolfi G, Radi D, Argento C, Baraldi E, Artenisio AC, et al. Anti-Mullerian hormone (AMH) as a predictive marker in assisted reproductive technology (ART). Hum Reprod Update 2010;16:113-30. https://doi.org/10.1093/humupd/dmp036
  7. Almog B, Shehata F, Suissa S, Holzer H, Shalom-Paz E, La Marca A, et al. Age-related normograms of serum antimullerian hormone levels in a population of infertile women: a multicenter study. Fertil Steril 2011;95:2359-63.e1. https://doi.org/10.1016/j.fertnstert.2011.02.057
  8. Barad DH, Weghofer A, Gleicher N. Utility of age-specific serum anti-Mullerian hormone concentrations. Reprod Biomed Online 2011;22:284-91. https://doi.org/10.1016/j.rbmo.2010.12.002
  9. La Marca A, Sighinolfi G, Giulini S, Traglia M, Argento C, Sala C, et al. Normal serum concentrations of anti-Mullerian hormone in women with regular menstrual cycles. Reprod Biomed Online 2010;21:463-9. https://doi.org/10.1016/j.rbmo.2010.05.009
  10. Seifer DB, Baker VL, Leader B. Age-specific serum anti-Mullerian hormone values for 17,120 women presenting to fertility centers within the United States. Fertil Steril 2011;95:747-50. https://doi.org/10.1016/j.fertnstert.2010.10.011
  11. Behringer RR, Finegold MJ, Cate RL. Mullerian-inhibiting substance function during mammalian sexual development. Cell 1994;79:415-25. https://doi.org/10.1016/0092-8674(94)90251-8
  12. Vigier B, Picard JY, Tran D, Legeai L, Josso N. Production of anti-Mullerian hormone: another homology between Sertoli and granulosa cells. Endocrinology 1984;114:1315-20. https://doi.org/10.1210/endo-114-4-1315
  13. Visser JA, de Jong FH, Laven JS, Themmen AP. Anti-Mullerian hormone: a new marker for ovarian function. Reproduction 2006;131:1-9. https://doi.org/10.1530/rep.1.00529
  14. Gruijters MJ, Visser JA, Durlinger AL, Themmen AP. Anti-Mullerian hormone and its role in ovarian function. Mol Cell Endocrinol 2003;211:85-90. https://doi.org/10.1016/j.mce.2003.09.024
  15. Fanchin R, Schonauer LM, Righini C, Guibourdenche J, Frydman R, Taieb J. Serum anti-Mullerian hormone is more strongly related to ovarian follicular status than serum inhibin B, estradiol, FSH and LH on day 3. Hum Reprod 2003;18:323-7. https://doi.org/10.1093/humrep/deg042
  16. Lekamge DN, Barry M, Kolo M, Lane M, Gilchrist RB, Tremellen KP. Anti-Mullerian hormone as a predictor of IVF outcome. Reprod Biomed Online 2007;14:602-10. https://doi.org/10.1016/S1472-6483(10)61053-X
  17. Wunder DM, Guibourdenche J, Birkhauser MH, Bersinger NA. Anti-Mullerian hormone and inhibin B as predictors of pregnancy after treatment by in vitro fertilization/intracytoplasmic sperm injection. Fertil Steril 2008;90:2203-10. https://doi.org/10.1016/j.fertnstert.2007.10.078
  18. Barad DH, Weghofer A, Gleicher N. Comparing anti-Mullerian hormone (AMH) and follicle-stimulating hormone (FSH) as predictors of ovarian function. Fertil Steril 2009;91:1553-5. https://doi.org/10.1016/j.fertnstert.2008.09.069
  19. Smeenk JM, Sweep FC, Zielhuis GA, Kremer JA, Thomas CM, Braat DD. Antimullerian hormone predicts ovarian responsiveness, but not embryo quality or pregnancy, after in vitro fertilization or intracyoplasmic sperm injection. Fertil Steril 2007;87:223-6. https://doi.org/10.1016/j.fertnstert.2006.06.019
  20. Lee TH, Liu CH, Huang CC, Wu YL, Shih YT, Ho HN, et al. Serum anti-Mullerian hormone and estradiol levels as predictors of ovarian hyperstimulation syndrome in assisted reproduction technology cycles. Hum Reprod 2008;23:160-7.
  21. de Vet A, Laven JS, de Jong FH, Themmen AP, Fauser BC. Antimullerian hormone serum levels: a putative marker for ovarian aging. Fertil Steril 2002;77:357-62. https://doi.org/10.1016/S0015-0282(01)02993-4
  22. Lee MM, Donahoe PK, Hasegawa T, Silverman B, Crist GB, Best S, et al. Mullerian inhibiting substance in humans: normal levels from infancy to adulthood. J Clin Endocrinol Metab 1996;81:571-6. https://doi.org/10.1210/jc.81.2.571
  23. Jurema MW, Bracero NJ, Garcia JE. Fine tuning cycle day 3 hormonal assessment of ovarian reserve improves in vitro fertilization outcome in gonadotropin-releasing hormone antagonist cycles. Fertil Steril 2003;80:1156-61. https://doi.org/10.1016/S0015-0282(03)02159-9
  24. Bancsi LF, Broekmans FJ, Mol BW, Habbema JD, te Velde ER. Performance of basal follicle-stimulating hormone in the prediction of poor ovarian response and failure to become pregnant after in vitro fertilization: a meta-analysis. Fertil Steril 2003;79:1091-100. https://doi.org/10.1016/S0015-0282(03)00078-5
  25. Bancsi LF, Broekmans FJ, Looman CW, Habbema JD, te Velde ER. Predicting poor ovarian response in IVF: use of repeat basal FSH measurement. J Reprod Med 2004;49:187-94.
  26. van Rooij IA, Broekmans FJ, te Velde ER, Fauser BC, Bancsi LF, de Jong FH, et al. Serum anti-Mullerian hormone levels: a novel measure of ovarian reserve. Hum Reprod 2002;17:3065-71. https://doi.org/10.1093/humrep/17.12.3065
  27. Bancsi LF, Broekmans FJ, Eijkemans MJ, de Jong FH, Habbema JD, te Velde ER. Predictors of poor ovarian response in in vitro fertilization: a prospective study comparing basal markers of ovarian reserve. Fertil Steril 2002;77:328-36. https://doi.org/10.1016/S0015-0282(01)02983-1
  28. La Marca A, Giulini S, Tirelli A, Bertucci E, Marsella T, Xella S, et al. Anti-Mullerian hormone measurement on any day of the menstrual cycle strongly predicts ovarian response in assisted reproductive technology. Hum Reprod 2007;22:766-71. https://doi.org/10.1093/humrep/del421
  29. Seifer DB, MacLaughlin DT, Christian BP, Feng B, Shelden RM. Early follicular serum mullerian-inhibiting substance levels are associated with ovarian response during assisted reproductive technology cycles. Fertil Steril 2002;77:468-71. https://doi.org/10.1016/S0015-0282(01)03201-0
  30. Eldar-Geva T, Ben-Chetrit A, Spitz IM, Rabinowitz R, Markowitz E, Mimoni T, et al. Dynamic assays of inhibin B, anti-Mullerian hormone and estradiol following FSH stimulation and ovarian ultrasonography as predictors of IVF outcome. Hum Reprod 2005;20:3178-83. https://doi.org/10.1093/humrep/dei203
  31. Buyuk E, Seifer DB, Younger J, Grazi RV, Lieman H. Random anti-Mullerian hormone (AMH) is a predictor of ovarian response in women with elevated baseline early follicular follicle-stimulating hormone levels. Fertil Steril 2011;95:2369-72. https://doi.org/10.1016/j.fertnstert.2011.03.071
  32. Silberstein T, MacLaughlin DT, Shai I, Trimarchi JR, Lambert-Messerlian G, Seifer DB, et al. Mullerian inhibiting substance levels at the time of HCG administration in IVF cycles predict both ovarian reserve and embryo morphology. Hum Reprod 2006;21:159-63. https://doi.org/10.1093/oxfordjournals.humrep.a002489
  33. Ebner T, Sommergruber M, Moser M, Shebl O, Schreier-Lechner E, Tews G. Basal level of anti-Mullerian hormone is associated with oocyte quality in stimulated cycles. Hum Reprod 2006;21:2022-6. https://doi.org/10.1093/humrep/del127
  34. Wang JG, Douglas NC, Nakhuda GS, Choi JM, Park SJ, Thornton MH, et al. The association between anti-Mullerian hormone and IVF pregnancy outcomes is influenced by age. Reprod Biomed Online 2010;21:757-61. https://doi.org/10.1016/j.rbmo.2010.06.041

피인용 문헌

  1. Clinical application of anti-M$\ddot{u}$llerian hormone as a predictor of controlled ovarian hyperstimulation outcome vol.39, pp.4, 2011, https://doi.org/10.5653/cerm.2012.39.4.176
  2. Notch signaling pathway in cumulus cells can be a novel marker to identify poor and normal responder IVF patients vol.30, pp.10, 2013, https://doi.org/10.1007/s10815-013-0072-4
  3. The interrelationship between anti-Müllerian hormone, ovarian follicular populations and age in mares : Anti-Müllerian hormone and ovarian follicular populations vol.47, pp.5, 2011, https://doi.org/10.1111/evj.12328
  4. Fertility of patients with polycystic ovary syndrome undergoing in vitro fertilization by age vol.135, pp.1, 2016, https://doi.org/10.1016/j.ijgo.2016.03.033
  5. Predictive values of anti-müllerian hormone, antral follicle count and ovarian response prediction index (ORPI) for assisted reproductive technology outcomes vol.37, pp.1, 2011, https://doi.org/10.1080/01443615.2016.1225025
  6. Serum anti-Müllerian hormone levels decrease after endometriosis surgery vol.37, pp.3, 2011, https://doi.org/10.1080/01443615.2016.1239071
  7. Serum Anti-Müllerian Hormone Levels in Precocious Puberty Girls according to Stage of GnRH Agonist Treatment vol.32, pp.3, 2017, https://doi.org/10.3346/jkms.2017.32.3.475
  8. Comparison of the Predictive Value of Antral Follicle Count, Anti-M&#252;llerian Hormone and Follicle-Stimulating Hormone in Women Following GnRH-Antagonist Protocol for Intracytoplasmic Sperm Inj vol.7, pp.4, 2011, https://doi.org/10.4236/ojog.2017.74045
  9. The cutoff values of serum AMH levels and starting recFSH doses for the individualization of IVF treatment strategies vol.33, pp.6, 2011, https://doi.org/10.1080/09513590.2017.1294154
  10. The likelihood of achieving pregnancy through timed coitus in young infertile women with decreased ovarian reserve vol.45, pp.1, 2011, https://doi.org/10.5653/cerm.2018.45.1.31
  11. Antimullerian hormone (AMH) level and IVF/ICSI cycle outcome in expected poor responders vol.23, pp.3, 2011, https://doi.org/10.1016/j.mefs.2017.10.007
  12. Anti-Müllerian hormone and embryo quality as determined by time-lapse imaging vol.72, pp.3, 2011, https://doi.org/10.23736/s0026-4784.20.04546-3