Current Situation on Signing Advance Medical Directives and Actual Life-sustaining Treatment Given at a University Hospital

일개 대학병원의 연명치료 선택 및 사전의료의향서 작성 현황

  • Yoon, Ho-Min (Department of Family Medicine, Korea University Guro Hospital) ;
  • Choi, Youn-Seon (Department of Family Medicine, Korea University Guro Hospital) ;
  • Hyun, Jong-Jin (Division of Gastroenterology, Department of Internal Medicine, Korea University Anam Hospital)
  • 윤호민 (고려대학교 구로병원 가정의학과) ;
  • 최윤선 (고려대학교 구로병원 가정의학과) ;
  • 현종진 (고려대학교 안암병원 소화기내과)
  • Received : 2010.02.03
  • Accepted : 2011.04.20
  • Published : 2011.06.01

Abstract

Purpose: This study was performed to investigate patients' preferences on receiving life-sustaining treatments (LST) and to analyze the relationship between patients' characteristics and LST selection. We also examined any discrepancy between LST patients' choices regarding medical intervention and actual medical intervention given/not given within 48 hours before death. Methods: This cross-sectional study was performed from March 1, 2008 to August 31, 2008 in the Palliative Care Unit of Korea University Hospital. Electric medical records (EMR) of 102 hospice cancer patients were reviewed, and 74 patients with Glasgow coma scale (GCS) ${\geq}$10 at the time of signing the advance medical directives (AMD) were selected for the first analysis. Then, patients alive at the end of this study, transferred to other hospitals or dead within 48 hours were excluded, and the remaining 42 patients were selected for the second analysis. Results: Preferred LST included antibiotics, total parenteral nutrition, tube feeding, transfusion, and laboratory and imaging studies. The relationship between patients' characteristics and LST could not be analyzed due to skewed preferences. LST chosen at the time of signing the AMD and actual medical intervention given/not given in the last 48 hours showed discrepancy in most cases. Conclusion: When making AMD in hospice cancer patients, it is important to consider the time and possibility of changing the choices. Above all, patients must fully understand the AMD. Thus, LST should always be provided with careful consideration of all possibilities, because legal and social aspects of AMD have not been established yet.

목적: 이 연구는 첫째, 입원 당시 호스피스 암환자들이 작성한 사전의료의향서를 통해 연명치료에 대한 선호 및 호스피스 암환자들의 특성과 연명치료 항목간의 관련성을 분석하며, 둘째, 호스피스병동 입원 시 작성한 사전의료의향서의 내용과 임종 48시간 이전에 시행되었던 의료중재간의 일치 여부를 평가하는 데 있다. 방법: 2008년 3월 1일부터 8월 31일까지 대학병원 완화의료센터에 입원하여 사전의료의향서를 작성한 호스피스 암환자 102명의 전자의무기록을 검토하여, 그 중 사전의료의향서 작성 당시 의식이 명료했던($10{\geq}GCS$) 74명을 대상으로 선택항목에 대한 빈도와 환자의 어떤 특성이 항목선택 요인으로 작용하는지 단변량 로지스틱 분석을 통하여 알아보았고, 그 중 사망한 42명을 대상으로 환자의 선택과 의료중재의 일치 여부를 대상자 별로 나누어 빈도로 나타내었고, 항목별로는 맥네마 검정을 시행하였다. 결과: 환자들은 항생제, 정맥영양, 경관영양, 수혈, 검사실 검사 및 방사선 검사를 연명치료로서 선호하였다. 환자의 특성과 연명치료 선택과의 상관관계는 연명치료에 대한 편향된 선호로 인해 분석할 수 없었다. 사전의료의향서 작성 당시 환자가 선택한 연명치료 여부와, 사망 48시간 이전에 실제로 시행되거나 시행되지 않은 연명치료는 거의 모든 경우에서 불일치를 보였다. 결론: 호스피스 암환자들에게 있어서, 사전의료의향서의 작성은 그 시기도 중요하지만, 환자, 보호자 및 대리인의 선택이 바뀔 수 있음도 고려해야 하고, 가장 중요한 것은 사전의료의향서에 대하여 작성자가 충분히 이해하고 있는 가이다. 따라서 사회적, 법적 제도화가 이루어지지 않은 현 시점의 연명치료는 모든 가능성을 염두에 두고 항상 신중하게 이루어져야 한다.

Keywords

References

  1. Kouwenhoven WB, Jude JR, Knickerbocker GG. Closed-chest cardiac massage. JAMA 1960;173:1064-7. https://doi.org/10.1001/jama.1960.03020280004002
  2. Symmers WS Sr. Not allowed to die. Br Med J 1968;1(5589): 442.
  3. Helft PR, Siegler M, Lantos J. The rise and fall of the futility movement. N Engl J Med 2000;343(4):293-6. https://doi.org/10.1056/NEJM200007273430411
  4. Schneiderman LJ, Jecker NS, Jonsen AR. Medical futility: its meaning and ethical implications. Ann Intern Med 1990;112(12):949-54. https://doi.org/10.7326/0003-4819-112-12-949
  5. Heo DS. Withholding futile interventions from tminally ill cancer patients. J Korean Med Assoc 2001;44(9):956-62.
  6. Zawacki BE. The "futility debate" and the management of Gordian knots. J Clin Ethics 1995;6(2):112-27.
  7. Youngner SJ. Medical futility. Crit Care Clin 1996;12(1):165-78. https://doi.org/10.1016/S0749-0704(05)70222-0
  8. Prendergast TJ. Resolving conflicts surrounding end-of-life care. New Horiz 1997;5(1):62-71.
  9. Charles WP, Robert MT Jr, Alan H, Dwight M, Leonard M, Herbert R, et al. Medical futility in end-of-life care: report of the Council on Ethical and Judicial Affairs. JAMA 1999;281(10):937-41. https://doi.org/10.1001/jama.281.10.937
  10. South-Paul JE, Matheny SC, Lewis EL. Current diagnosis & treatment in family medicine [Internet]. 2nd ed. New York: McGraw-Hill; 2008. Chapter 63, Hospice & palliative medicine. Available from: http://www.accessmedicine.com/content.aspx?aid=3038287.
  11. Charles C, Gafni A, Whelan T. Decision-making in the physicianpatient encounter: revisiting the shared treatment decision-making model. Soc Sci Med 1999;49(5):651-61. https://doi.org/10.1016/S0277-9536(99)00145-8
  12. Shim BY, Hong SI, Park JM, Cho HJ, Ok JS, Kim SY, et al. DNR (Do-Not-Resuscitate) order for terminal cancer patients at hospice ward. Korean J Hosp Palliat Care 2004;7(2):232-7.
  13. Office of the Law Revision Counsel [Internet]. Pittsburgh, PA: U.S. Government Printing Office; 1990. 42 U.S.C. 4206, 4751, 1395cc(a)(1)(2), 1395mm(c)(8), 1395cc(f), 1396a(a)(57), 1396a(a)(58), and 1396a(w) [cited 2009 June 19]. Available from: http://uscode.house.gov/lawrevisioncounsel.shtml.
  14. Advance Medical Directives [Internet]. Seoul: Seoul National University Hospital; 2009 [cited 2009 July 19]. Available from: http://www.snuh.org/pub/ICSFiles/afieldfile/2009/07/07/snuh_02.doc.
  15. Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 1982;5(6):649-55. https://doi.org/10.1097/00000421-198212000-00014
  16. Lee IC, Kim CK, Suh SY, Kim YS, Cho KH, Kang HC, et al. Validation of scoring system for survival prediction in terminal cancer patients in Korea. J Korean Acad Fam Med 2007;28(9):682-9.
  17. Crane MK, Wittink M, Doukas DJ. Respecting end-of-life treatment preferences. Am Fam Physician 2005;72(7):1263-8.
  18. Pence GE. Classic cases in medical ethics. 3rd ed. Boston: McGraw-Hil;2000. p. 29-51.
  19. The hospice and palliative act [Internet]. Taiwan: Department of Health, Executive Yuan, R.O.C; 2002. [cited 2008 Nov 25]. Available from: http://www.doh.gov.tw.
  20. Allmer G. Bundesgesetz über patientenverfügungen: Patientenverfügungs- Gesetz. BGBI [Internet]. 2006; 55: 1-5 [cited 2008 Nov 25]. Available from: http://www.pflegerecht.at/Druck/Versionen-Patientenrechte/Bund/Druckversion-PatVG.pdf.
  21. Jung HS. Current practices of the ceasing medical treatment for euthanasia and its solutions. KSOLM 2008;9(1):461-503.
  22. Code of medical ethics [Internet]. Seoul: Korean Medical Association; 2006. [cited 2009 June 22]. Available from: http://www.kma.org/contents/intro/intro03.html.
  23. Yun YH. Hospice care for improving terminally ill patients' quality of life. J Korean Med Assoc 2008;51(6):530-5. https://doi.org/10.5124/jkma.2008.51.6.530
  24. Ioannes Paulus PP. II. Evangelium vitae [Internet]. Vatican City: Libreria Editrice Vaticana; c1995. [cited 2009 June 22]. Available from: http://www.vatican.va/holy_father/john_paul_ii/encyclicals/documents/hf_jp-ii_enc_25031995_evangelium-vitae_en.html.
  25. Purtilo R. Ethical dimensions in the health professions. 2nd ed. Philadelphia:W.B. Saunders;1995. p. 220.
  26. Danis M, Southerland LI, Garrett JM, Smith JL, Hielema F, Pickard CG, et al. A prospective study of advance directives for life-sustaining care. N Engl J Med 1991;324(13):882-8. https://doi.org/10.1056/NEJM199103283241304
  27. Cooper JK, Weber JA, Evans P, Juozapavicius K. End-of-life decisions: physicians as advocates for advance directives. J Am Osteopath Assoc 2001;101(10):571-5.
  28. Aitken PV Jr. Incorporating advance care planning into family practice [see comment]. Am Fam Physician 1999;59(3):605-14, 617-20.
  29. Burt RA. The medical futility debate: patient choice, physician obligation, and end-of-life care. J Palliat Med 2002;5(2):249-54. https://doi.org/10.1089/109662102753641223
  30. Oh DY, Kim JE, Lee CH, Lim JS, Jung KH, Heo DS, et al. Discrepancies among patients, family members, and physicians in Korea in terms of values regarding the withholding of treatment from patients with terminal malignancies. Cancer 2004;100(9):1961-6. https://doi.org/10.1002/cncr.20184
  31. Aronsky D, Kasworm E, Jacobson JA, Haug PJ, Dean NC. Electronic screening of dictated reports to identify patients with do-not-resuscitate status. J Am Med Inform Assoc 2004;11(5):403-9. https://doi.org/10.1197/jamia.M1518