Toxicological Research

  • 제27권2호
  • /
  • Pages.95-102
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  • 2011
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
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Effect of DHU001, a Polyherbal Formula on Formalin-induced Paw Chronic Inflammation of Mice

  • Cho, Yoon-Hee (Department of Clinical Laboratory Science, College of Health and Therapy) ;
  • Chung, In-Kwon (College of Oriental Medicine, Daegu Haany University) ;
  • Cheon, Woo-Hyun (College of Oriental Medicine, Daegu Haany University) ;
  • Lee, Hyeung-Sik (Department of Clinical Laboratory Science, College of Health and Therapy) ;
  • Ku, Sae-Kwang (College of Oriental Medicine, Daegu Haany University)
  • 투고 : 2011.05.01
  • 심사 : 2011.05.13
  • 발행 : 2011.06.01
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초록

The effect of DHU001, a mixed herbal formula consisted of 7 types aqueous extracts for various respiratory disorders were evaluated on the formalin-induced paw chronic inflammation in mice after oral administration. Mice were subaponeurotically injected in the left hind paw with 0.02 ml of 3.75% formalin, then subjected to 500, 250 and 125 mg/kg of DHU001 oral administration, once a day for 10 days during which then the hind-paw thickness and volume were measured daily. The paw wet-weight, histological profiles, histomorphometrical analyses and paw tumor necrosis factor (TNF)-${\alpha}$ contents were conducted at termination. After two formalin treatments, a marked increase in the paw thickness and volume was detected in the formalin-injected control as compared with that in the intact control, plus at the time of sacrifice the paw wet-weights, paw TNF-${\alpha}$ contents were also dramatically increased with severe chronic inflammation signs at histopathological observations. However, these formalin-induced chronic inflammatory changes were dramatically decreased by treatment of dexamethasone and all three different dosages of DHU001. DHU001 has favorable effects on formalin-induced chronic inflammation mediated by TNF-${\alpha}$ suppression, and DHU001 may represent an alternative approach for the treatment of chronic inflammatory diseases.

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참고문헌

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