Journal of Yeungnam Medical Science
- 제28권1호
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- Pages.77-83
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- 2011
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- 2799-8010(eISSN)
전이성 혈관주위세포종 환자에서 발생한 저혈당을 프레드니솔론으로 치료한 1예
Treatment of Hemangiopericytoma-Associated Hypoglycemia with Glucocorticoid Therapy
- 박성우 (영남대학교 의과대학 내과학교실) ;
- 김동근 (영남대학교 의과대학 내과학교실) ;
- 김명진 (영남대학교 의과대학 내과학교실) ;
- 장효진 (영남대학교 의과대학 내과학교실) ;
- 손세훈 (영남대학교 의과대학 내과학교실) ;
- 고성애 (영남대학교 의과대학 내과학교실) ;
- 이하영 (영남대학교 의과대학 내과학교실) ;
- 김민경 (영남대학교 의과대학 내과학교실) ;
- 이경희 (영남대학교 의과대학 내과학교실) ;
- 현명수 (영남대학교 의과대학 내과학교실)
- Park, Sung-Woo (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
- Kim, Dong-Geun (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
- Kim, Myung-Jin (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
- Jang, Hyo-Jin (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
- Sohn, Se-Hoon (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
- Koh, Sung-Ae (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
- Lee, Ha-Young (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
- Kim, Min-Kyoung (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
- Lee, Kyoung-Hee (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
- Hyun, Myung-Soo (Department of Internal Medicine, College of Medicine, Yeungnam University)
- 발행 : 2011.06.30
초록
Non-islet cell tumor-induced hypoglycemia (NICTH) is associated with mesenchymal tumor types, including hemangiopericytoma, fibrosarcoma, mesothelioma, and neurofibroma, as well as carcinoma of the liver, adrenal glands, and kidneys. Non- islet cell tumors induce hypoglycemia by overproducing an abnormal form of insulin-like growth factor II (IGF m. Complete removal of the tumor or reduction of the tumor mass is a successful therapeutic strategy in cases of NICTH. However, if the tumor re-grows, curative resection is nearly impossible, and hypoglycemia occurs repeatedly. Glucocorticoids are effective in terms of long-term relief from hypoglycemia through promotion of gluconeogenesis in the liver, tumor suppression, production of 'big'-IGF-II, and correction of the attendant biochemical abnormalities involving the growth hormone (GH)-IGF axis. We found that administration of corticosteroid therapy to a patient suffering from NICTH resulted in improvement of hypoglycemia associated symptoms.