Journal of Yeungnam Medical Science

Yeungnam University College of Medicine, Yeungnam University Institute Medical Science (영남대 의대 학술지 편집위원회)
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Rhabdomyolysis Induced Acute Kidney Injury in a Patient with Leptospirosis

횡문근융해증에 의한 급성 신 손상이 동반된 렙토스피라증 1예

  • Choi, Yoon-Jung (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Park, Jeung-Min (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Jung, Yo-Han (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Nam, Jong-Ho (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Chung, Hyun-Hee (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Kim, Tae-Woo (Soonchunhyang University Gumi Hospital) ;
  • Cho, Kyu-Hyang (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Do, Jun-Young (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Yun, Kyeung-Woo (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Park, Jong-Won (Department of Internal Medicine, College of Medicine, Yeungnam University)
  • 최윤정 (영남대학교 의과대학 내과학교실) ;
  • 박정민 (영남대학교 의과대학 내과학교실) ;
  • 정요한 (영남대학교 의과대학 내과학교실) ;
  • 남종호 (영남대학교 의과대학 내과학교실) ;
  • 정현희 (영남대학교 의과대학 내과학교실) ;
  • 김태우 (순천향대학교 구미병원) ;
  • 조규향 (영남대학교 의과대학 내과학교실) ;
  • 도준영 (영남대학교 의과대학 내과학교실) ;
  • 윤경우 (영남대학교 의과대학 내과학교실) ;
  • 박종원 (영남대학교 의과대학 내과학교실)
  • Published : 2011.06.30
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Abstract

Leptospirosis is a spirochetal infectious disease caused by $Leptospira$ $interrogans$, and may vary in degree from an asymptomatic infection to a severe and fatal illness. The kidney is one of the principal target organs of $Leptospira$. Renal disorders caused by $Leptospira$ infection vary from an abnonnality in urinalysis to acute kidney injury (AKI). Incidence of AKI in severe leptospirosis varies from 40% to 60%. AKI reflects the severity of leptospirosis and is generally accompanied by cholestatic jaundice. The pathophysiology of AKI in leptospirosis consists of hypovolemia, direct tubular toxicity, and rhabdomyolysis. Most patients with acute leptospirosis experience severe myalgias, and show laboratory evidence of mild rhabdomyolysis. However, occurrence of severe rhabdomyolysis is rare. We report here on a patient with leoptospirosis, who had severe rhabdomyolysis and acute kidney injury without jaundice.

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