Journal of Yeungnam Medical Science

Yeungnam University College of Medicine, Yeungnam University Institute Medical Science (영남대 의대 학술지 편집위원회)
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Development of Steroid Myopathy during Polymyositis Treatment

다발성 근염 환자에서 발생한 스테로이드 근병증 1예

  • Lee, Ji-Hoon (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Hyun, Shin-Young (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Kim, Choong-Ki (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Lee, Su-Hwan (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Choi, A-Ra (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Kim, Seong-Woo (Department of Physical Medicine and Rehabilitation, National Health Insurance Corporation Ilsan Hospital) ;
  • Park, Sung-Hye (Department of Pathology, College of Medicine, Seoul National University) ;
  • Lee, Chan-Hee (Department of Internal Medicine, Division of Rheumatology, National Health Insurance Corporation Ilsan Hospital)
  • 이지훈 (연세대학교 의과대학 내과학교실) ;
  • 현신영 (연세대학교 의과대학 내과학교실) ;
  • 김충기 (연세대학교 의과대학 내과학교실) ;
  • 이수환 (연세대학교 의과대학 내과학교실) ;
  • 최아라 (연세대학교 의과대학 내과학교실) ;
  • 김성우 (국민건강보험공단 일산병원 재활의학과) ;
  • 박성혜 (서울대학교 의과대학 병리학교실) ;
  • 이찬희 (국민건강보험공단 일산병원 류마티스내과)
  • Published : 2011.12.30
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Abstract

Polymyositis is diffuse, inflammatory myopathy with proximal-muscle weakness due to lymphocyte infiltration to the muscle layer. The exact cause of the muscle weakness is unclear but may be related with an immunologic mechanism. Using high-dose steroid is the treatment of choice for polymyositis. It is difficult to distinguish steroid-resistant polymyositis from steroid myopathy, however, in the course of high-dose steroid therapy. These authors encountered a steroid myopathy patient during polymyositis treatment with high-dose steroid. A 57-year-old woman was diagnosed with polymyositis and was treated with high-dose steroid. Her condition was initially improved, but in the course of the treatment, her symptom was aggravated without increasing the muscle enzymes. Her muscle weakness was improved by reducing the steroid dosage.

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