Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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Effects of $Angelica$ $Gigantis$ Pharmacopuncture Extracts on the Elastase Activity and DPPH and NO Scavenging Activities

당귀약침액의 Elastase 효소 활성과 DPPH, NO 소거능에 미치는 영향

  • Lee, Se-Min (Dept. of Acupuncture & Moxibustion College of Oriental Medicine, Daegu Hanny University) ;
  • Lim, Seong-Chul (Dept. of Acupuncture & Moxibustion College of Oriental Medicine, Daegu Hanny University) ;
  • Lee, Yun-Kyu (Dept. of Acupuncture & Moxibustion College of Oriental Medicine, Daegu Hanny University) ;
  • Kim, Jae-Soo (Dept. of Acupuncture & Moxibustion College of Oriental Medicine, Daegu Hanny University)
  • 이세민 (대구한의대학교 한의과대학 침구학교실) ;
  • 임성철 (대구한의대학교 한의과대학 침구학교실) ;
  • 이윤규 (대구한의대학교 한의과대학 침구학교실) ;
  • 김재수 (대구한의대학교 한의과대학 침구학교실)
  • Received : 2011.10.31
  • Accepted : 2011.11.28
  • Published : 2011.12.20
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Abstract

목적 : Elastin 섬유는 피부, 폐, 동맥, 정맥 등 조직에서 발견된다. Elastin 섬유의 손실은 대동맥, 동맥, 세동맥의 탄력 등과 연관되어 폐기종, 혈액순환 부전 및 폐동맥 고혈압을 악화시킬 수 있다. 본 연구는 당귀약침액의 elastase 효소활성에 대한 효과와 항산화 효과에 대하여 연구하고자 계획되었다. 방법 : 당귀약침액의 elastase 억제효과와 DPPH, 및 NO 소거능을 측정하여 항산화 효과를 측정하였다. 결과 : 당귀약침액에서 통계적으로 유의한 elastase 활성 억제효과를 관찰할 수 있었다. 또한 통계적으로 강한 DPPH free radical 소거 효과가 관찰되었다. 그리고 NO 소거효과를 관찰할 수 있었으며, 그 효능은 pH 6.0에서 가장 강한 효능을 보였다. 결론 : 본 연구 결과에 의하면, 당귀약침액에는 유효한 elastase 활성 억제효과와 강한 항산화 효과가 있어, 폐기종 및 폐동맥 고혈압 치료에 유효한 작용이 있을 것으로 사료된다.

Keywords

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