Nutrition Research and Practice

  • 제5권1호
  • /
  • Pages.20-27
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  • 2011
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  • 1976-1457(pISSN)
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  • 2005-6168(eISSN)
한국영양학회 (The Korean Nutrition Society)
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Effects of a safflower tea supplement on antioxidative status and bone markers in postmenopausal women

  • Choi, Sung-Hee (Department of Food Science and Nutrition, Catholic University of Daegu) ;
  • Jang, Jeong-Hee (Department of Food Science and Nutrition, Catholic University of Daegu) ;
  • Yoon, Ji-Young (Department of Food Science and Nutrition, Catholic University of Daegu) ;
  • Hahn, Chi-Dong (Department of Obstetrics and Gynecology, Daegu Catholic Univ. Medical Center) ;
  • Choi, Young-Sun (Department of Food and Nutrition, Daegu University) ;
  • Choi, Sang-Won (Department of Food Science and Nutrition, Catholic University of Daegu)
  • 투고 : 2010.09.01
  • 심사 : 2010.11.03
  • 발행 : 2011.02.28
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초록

We conducted this study to examine the effects of safflower seed granular tea containing physiologically active polyphenols on antioxidative activities and bone metabolism. Forty postmenopausal women ages 49 to 64-years were recruited from Daegu and Gyeongbuk and were randomly assigned to either a safflower tea supplement (Saf-tea) group (n=27) or a placebo group (n=13). The Saf-tea group received 20 g of safflower seed granule tea per day containing a 13% ethanol extract of defatted safflower seeds, whereas the placebo group received a similar type of tea that lacked the ethanol extract. No significant changes in nutrient intake for either the placebo or Saf-tea groups were observed before or after the study period, except vitamin A intake increased after 6 months in the Saf-tea group. Dietary phytoestrogen intakes were similar in the Saf-tea group (60.3 mg) and placebo group (52.5 mg). Significant increases in plasma genistein and enterolactone were observed in the Saf-tea group. After 6 months of supplementation, serum levels of antioxidant vitamins such as a-tocopherol and ascorbic acid increased significantly, and TBARS levels decreased in the Saf-tea group compared to the placebo group. Serum osteocalcin levels were reduced (P<0.05) in the Saf-tea group after 6 months, whereas serum osteocalcin did not change in the placebo group. Urinary deoxypyridinoline/creatinine excretion was not different between the two groups at baseline, and did not change in either group after 6 months. Bone mineral density decreased significantly in the placebo group (P<0.01) but not in the supplemented group. It was concluded that polyphenols (72 mg/day), including serotonin derivatives, in the Saf-tea had both antioxidant and potential bone protecting effects in postmenopausal women without liver toxicity.

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참고문헌

  1. Huh J. Herbe, Dongeui Bogam, Vol. 3. Seoul: Yeogang Publisher; 1989. p.2763.
  2. Kim JH, Jeon SM, An MY, Ku SK, Lee JH, Choi MS, Moon KD. Effects of diet of Korean safflower (Carthamus tinctorius L.) seed powder on bone tissue in rats during the recovery of rib fracture. J Korean Soc Food Sci Nutr 1998;27:698-704.
  3. Chung SY, Choi HJ, Chung MW, Ahn MR, Yoo TM, Rheu HM, Yang JS. Effects of safflower seed on the fracture healing in rat tibia. Yakhak Hoeji 1999;43:526-34.
  4. Lee JY, Chang EJ, Kim HJ, Park JH, Choi SW. Antioxidative flavonoids from leaves of Carthamus tincotorius. Arch Pharm Res 2002;25:313-9. https://doi.org/10.1007/BF02976632
  5. Seo HJ, Kim JH, Kwak DY, Jeon SM, Ku SK, Lee JH, Moon KD, Choi MS. The effects of safflower seed powder and its fraction on bone tissue in rib-fractured rats during the recovery. Korean J Nutr 2000;33:411-20.
  6. Kim HJ, Bae YC, Park RW, Choi SW, Cho SH, Choi YS, Lee WJ. Bone-protecting effect of safflower seeds in ovariectomized rats. Calcif Tissue Int 2002;71:88-94. https://doi.org/10.1007/s00223-001-1080-4
  7. Cho SH, Choi SW, Choi YS, Kim HJ, Park YH, Bae YC, Lee WJ. Effect of ethanol extract of safflower seed on bone loss in ovariectomized rats. Food Sci Biotechnol 2007;16:392-7.
  8. Kang GH, Chang EJ, Choi SW. Antioxidative activity of phenolic compounds in roasted safflower (Carthamus tinctorious L.) seeds. J Food Sci Nutr 1999;4:221-5.
  9. Kim EO, Oh JH, Lee SK, Lee JY, Choi SW. Antioxidant properties and quantification of phenolic compounds from safflower (Carthamus tinctorius L.) seeds. Food Sci Biotechnol 2007;16:71-7.
  10. Kim EO, Kim KS, Lee WJ, Choi SW. Proliferative and differentiative effects of trachelogenin isolated from germinated safflower (Carthamus tinctorius L.) seeds on calvarial bone cells. Food Sci Biotechnol 2009;18:689-93.
  11. Kim JH, Choi MS, Moon KD. Quality characteristic of drink and tea-bag processed with safflower seed powder. Korean J Postharvest Sci Technol 2000;7:171-6.
  12. Kim JH, Park JH, Park SD, Choi SY, Seong JH, Moon KD. Preparation and antioxidant activity of health drink with extract powders from safflower (Carthamus tinctorius L.) seed. Korean J Food Sci Technol 2002;34:617-24.
  13. Kim JH, Kim JK, Kang WW, Kim GY, Choi MS, Moon KD. Preparation of functional healthy drinks by ethanol extracts from defatted safflower seed cake. J Korean Soc Food Sci Nutr 2003;32:1039-45. https://doi.org/10.3746/jkfn.2003.32.7.1039
  14. Cho SH, Lee HR, Choi SW, Lee WJ, Choi Y. Formulated product containing safflower seed extract improves lipid status of ovariectomized rats. Korean J Gerontol 2005;15:39-46.
  15. Jang JH, Yoon JY, Cho SH. Intake of dietary phytoestrogen and indices of antioxidant and bone metabolism of pre- and post-menopausal Korean women. Nutr Res Pract 2007;1:305-12. https://doi.org/10.4162/nrp.2007.1.4.305
  16. Bieri G, Tolliver TJ, Catignani GL. Simultaneous determination of alpha-tocopherol in plasma or red blood cells by high pressure liquid chromatography. Am J Clin Nutr 1979;32:2143-9.
  17. Yagi K. A simple fluorometric assay for lipoperoxide in blood plasma. Biochem Med 1976;15:212-6. https://doi.org/10.1016/0006-2944(76)90049-1
  18. Tarpila S, Aro A, Salminen I, Tarpila A, Kleemola P, Akkila J, Adlercreutz H. The effect of flaxseed supplementation in processed foods on serum fatty acids and enterolactone. Eur J Clin Nutr 2002;56:157-65. https://doi.org/10.1038/sj.ejcn.1601298
  19. Kuijsten A, Arts IC, van't Veer P, Hollman PH. The relative bioavailbility of enterolignans in humans is enhanced by milling and crushing of flaxseed. J Nutr 2005;135:2812-6.
  20. Lee DH, Lee HS, Kim MH, Yoon ME, Sung CJ. Effects of isoflavones supplementation on bone mineral density and sex hormones in postmenopausal women. Korean J Nutr 2002;35: 863-9.
  21. Wu J, Oka J, Higuchi M, Tabata I, Toda T, Fujioka M, Fuku N, Teramoto T, Okuhira T, Ueno T, Uchiyama S, Urata K, Yamada K, Ishimi Y. Cooperative effects of isoflavones and exercise on bone and lipid metabolism in postmenopausal Japanese women: a randomized placebo-controlled trial. Metabolism 2006; 55:423-33. https://doi.org/10.1016/j.metabol.2005.10.002
  22. Dalais FS, Ebeling PR, Kotsopoulos D, McGrath BP, Teede HJ. The effects of soy protein containing isoflavones on lipids and indices of bone resorption in postmenopausal women. Clin Endocrinol (Oxf) 2003;58:704-9. https://doi.org/10.1046/j.1365-2265.2003.01771.x
  23. Atkinson C, Compston JE, Day NE, Dowsett M, Bingham SA. The effects of phytoestrogen isoflavones on bone density in women: a double blind, randomized, placebo-controlled trial. Am J Clin Nutr 2004;79:326-33.
  24. Potter SM, Baum JA, Teng H, Stillman RJ, Shay NF, Erdman JW Jr. Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Am J Clin Nutr 1998;68:1375S-1379S.
  25. Clifton-Bligh PB, Barber RJ, Fulcher GR, Nery ML, Moerton T. The effect of isoflavones extracted from red clover (Rimostil) on lipid and bone metabolism. Menopause 2001;8:259-65. https://doi.org/10.1097/00042192-200107000-00007
  26. Alekel DL, Germain AS, Peterson CT, Hanson KB, Stewart JW, Toda T. Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. Am J Clin Nutr 2000;72:844-52.
  27. Gallagher JC, Satpathy R, Rafferty K, Haynatzka V. The effect of soy protein isolate on bone metabolism. Menopause 2004;11: 290-8.
  28. Lee BS, Won HJ, Lee SK, Choi Y, Yoon S, Park KH, Cho DJ, Song CH. The effect of isoflavone on serum lipid profiles and bone markers in postmenopausal women. J Korean Soc Menopause 2002;8:59-66.
  29. Uesugi T, Fukui Y, Yamori Y. Beneficial effects of soybean isoflavone supplementation on bone metabolism and serum lipids in postmenopausal Japanese women: A four-week study. J Am Coll Nutr 2002;21:97-102.
  30. Lucas EA, Wild RD, Hammond LJ, Khalil DA, Juma S, Daggy BP, Stoecker BJ, Arjmandi BH. Flaxseed improves lipid profile without altering biomarkers of bone metabolism in postmenopausal women. J Clin Endocrinol Metab 2002;87:1527-32. https://doi.org/10.1210/jc.87.4.1527
  31. Dodin S, Lemay A, Jacques H, Légaré F, Forest JC, Masse B. The effects of flaxseed dietary supplement on lipid profile, bone mineral density, and symptoms in menopausal women: a randomized, double-blind, wheat germ placebo-controlled clinical trial. J Clin Endocrinol Metab 2005;90:1390-7.
  32. Cornish SM, Chilibeck PD, Paus-Jennsen L, Biem HJ, Khozani T, Senanayake V, Vatanparast H, Little JP, Whiting SJ, Pahwa P. A randomized controlled trial of the effects of flaxseed lignan complex on metabolic syndrome composite score and bone mineral in older adults. Appl Physiol Nutr Metab 2009;34:89-98. https://doi.org/10.1139/H08-142
  33. Ward WE, Ynan YV, Cheung AM, Thompson LU. Exposure to flaxseed and its purified lignan reduces bone strength in young but not older male rats. J Toxicol Environ Health A 2001;63:53-65. https://doi.org/10.1080/152873901750128362
  34. Gustafsson BI, Westbroek I, Waarsing JH, Waldum H, Solligard E, Brunsvik A, Dimmen S, van Leeuwen JP, Weinans H, Syversen U. Long-term serotonin administration leads to higher bone mineral density, affects bone architecture, and leads to higher femoral bone stiffness in rats. J Cell Biochem 2006;97: 1283-91. https://doi.org/10.1002/jcb.20733
  35. Barnes S. The biochemistry, chemistry and physiology of the isoflavones in soybeans and their food products. Lymphat Res Biol 2010;8:89-98. https://doi.org/10.1089/lrb.2009.0030
  36. Choi Y, Yoon S, Lee MJ, Lee SK, Lee BS. Dose response relationship of isoflavone supplementation on plasma lipid profiles and total antioxidant status in perimenopausal and postmenopausal women. Korean J Nutr 2001;34:322-9.
  37. Lee JH, Kim EM, Chae JS, Jang YS, Lee JH, Lee G. The effect of isoflavone supplement on plasma lipids and antioxidant status in hypercholesterolemic postmenopausal women. Korean J Nutr 2003;36:603-12.
  38. Prasad K. Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed. Circulation 1999;99:1355-62. https://doi.org/10.1161/01.CIR.99.10.1355
  39. Niemeyer HB, Metzler M. Differences in the antioxidant activity of plant and mammalian lignans. J Food Eng 2003;56:255-6. https://doi.org/10.1016/S0260-8774(02)00263-7
  40. Cunnane SC, Hamadeh MJ, Liede AC, Thompson LU, Wolever TM, Jenkins DJ. Nutritional attributes of traditional flaxseed in healthy young adults. Am J Clin Nutr 1995;61:62-8.
  41. Vanharanta M, Voutilainen S, Numi T, Kaikkonen J, Roberts LJ, Morrow JD, Adlercreutz H, Salonen JT. Association between low serum enterolactone and increased plasma $F_2$-isoprostanes, a measure of lipid peroxidation. Atherosclerosis 2002;160:465-9. https://doi.org/10.1016/S0021-9150(01)00603-7
  42. Coulman KD, Liu Z, Michaelides J, Quan Hum W, Thompson LU. Fatty acids and lignans in unground whole flaxseed and sesame seed are bioavailable but have minimal antioxidant and lipid-lowering effects in postmenopausal women. Mol Nutr Food Res 2009;53:1366-75. https://doi.org/10.1002/mnfr.200900032
  43. Hallund J, Ravn-Haren G, Bügel S, Tholstrup T, Tetens I. A lignan complex isolated from flaxseed does not affect plasma lipid concentrations or antioxidant capacity in healthy postmenopausal women. J Nutr 2006;136:112-6.

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  2. White Tea Reduced Bone Loss by Suppressing the TRAP/CTX Pathway in Ovariectomy-Induced Osteoporosis Model Rats vol.209, pp.1, 2011, https://doi.org/10.1159/000507791
  3. Safflower Extract Inhibits ADP-Induced Human Platelet Aggregation vol.10, pp.6, 2011, https://doi.org/10.3390/plants10061192
  4. Role of Herbal Teas in Regulating Cellular Homeostasis and Autophagy and Their Implications in Regulating Overall Health vol.13, pp.7, 2011, https://doi.org/10.3390/nu13072162