The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Effects of Concurrent Administration of Hyeolbuchukeo-tang and Aspirin on Atherosclerosis in the $ApoE^{(-/-)}$ Mouse

동맥경화증이 유발된 $ApoE^{(-/-)}$ mouse에서 혈부축어탕(血府逐瘀湯)과 Aspirin의 병용투여 효과에 대한 연구

  • Lee, Beom-Joon (Dept. of Oriental Internal Medicine, Kangnam Korean Hospital, Kyunghee university) ;
  • Yun, Seung-Yeon (East-west Medicine, The graduate School of East-West Medical Science, Kyunghee university) ;
  • Park, Hyun-Woo (East-west Medicine, The graduate School of East-West Medical Science, Kyunghee university) ;
  • Park, Ji-Hyuk (East-west Medicine, The graduate School of East-West Medical Science, Kyunghee university) ;
  • Jo, In-Young (East-west Medicine, The graduate School of East-West Medical Science, Kyunghee university) ;
  • Lee, Jeong-Sook (East-west Medicine, The graduate School of East-West Medical Science, Kyunghee university) ;
  • Lew, Jae-Hwan (East-west Medicine, The graduate School of East-West Medical Science, Kyunghee university)
  • 이범준 (경희강남한방병원 한방내과) ;
  • 윤승연 (경희대학교 동서의학대학원 동서의학과) ;
  • 박현우 (경희대학교 동서의학대학원 동서의학과) ;
  • 박지혁 (경희대학교 동서의학대학원 동서의학과) ;
  • 조인영 (경희대학교 동서의학대학원 동서의학과) ;
  • 이정숙 (경희대학교 동서의학대학원 동서의학과) ;
  • 류재환 (경희대학교 동서의학대학원 동서의학과)
  • Received : 2010.12.16
  • Accepted : 2011.01.17
  • Published : 2011.01.30
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Abstract

Objective: The antiplatelet agent aspirin has been widely used for treating atherosclerosis in western medicine, and its efficacy has been proven in cardiac and extracardiac vascular diseases. On the other hand, Hyeolbuchukeo-tang has been widely used for treating blood stasis syndrome in traditional medicine. Therefore we investigated whether Hyeolbuchukeo-tang could have a synergic effect along with aspirin. Methods & Materials: Male $ApoE^{(-/-)}$ mice were randomly divided into three different experimental groups: a non-treated group(Control group), an aspirin-treated group(AP group), and an aspirin with Hyeolbuchukeo-tang-treated group(APH group). The control group was fed only an atherogenic diet, the AP group an atherogenic diet plus Aspirin 5 mg/kg, and the APH group an atherogenic diet plus Aspirin 5 mg/kg with Hyeolbuchukeo-tang 100 mg/kg. We investigated plasma lipid with liver function test, and performed the histological investigation of liver and abdominal aorta. Results: 1. We investigated photomicrographic changes of liver and abdominal aorta tissue. They showed that histological injury of aorta and lipid accumulations of the liver were lower in the AP and APH groups than in the control group. 2. In the APH group, plasma triglyceride levels were significantly lower than those in the control and AP groups. 3. There were no differences in aspartate aminotransferase and alanine aminotransferase levels among the control, AP and APH groups. Conclusion: The above results show that a combined treatment of Hyeolbuchukeo-tang and aspirin has a somewhat synergic effect in terms of inhibiting vessel injury and decreasing lipid deposits on liver cells without liver toxicity.

Keywords

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