한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제28권1호
  • /
  • Pages.113-121
  • /
  • 2011
  • /
  • 1598-298X(pISSN)
  • /
  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

구제역의 병인론과 숙주와의 상호작용

Pathogenesis and Host Interaction of Foot-and-mouth Disease

  • 심사 : 2010.08.03
  • 발행 : 2011.02.28
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Foot-and-mouth disease (FMD) is a severe vesicular disease of cloven-hoofed animals including domesticated ruminants and pigs. Acute clinical signs may be mild in sheep and goats but are associated with lameness in pigs and mouth lesions with vesicles in cattle. The required condition for a successful pathogen appears to be the ability to counteract both the host innate and adaptive immune response. FMD virus (FMDV) inhibits the induction of antiviral molecules and interferes with the secretory pathway in the infected cell. The surface expression of Major Histocompatibility Complex (MHC) class I molecules is reduced in infected cells. Thus, the ability of the host to recognize and eliminate virus infected cells is decreased. Furthermore, FMDV infection results in a rapid, but transient lymphopenia, reducing the number of T and B cells, and affecting T cell function. The virus appears to premature apoptosis-mediated cell death because it has a very short replication cycle and is able to rapidly produce large amounts of virus. FMDV engages the host protective response at multiple steps to ensure its effective replication and pathogenesis. This review describes the recent pathological and immunological studies to overcome the powerful abilities of FMDV to counteract defense mechanism of host.

키워드

참고문헌

  1. Alexandersen S, Mowat N. Foot-and-mouth disease: host range and pathogenesis. Curr Top Microbiol Immunol 2005; 288: 9-42.
  2. Alexandersen S, Zhang Z, Donaldson AI, Garland AJ. The pathogenesis and diagnosis of foot-and-mouth disease. J Comp Pathol 2003; 129: 1-36. https://doi.org/10.1016/S0021-9975(03)00041-0
  3. Bachrach HL. Foot-and-mouth disease. Annu Rev Microbiol 1968; 22: 201-244. https://doi.org/10.1146/annurev.mi.22.100168.001221
  4. Bae YC, Yoon SS, Kang KI, Roh IS, Kim HJ, So BJ, Park JW, Jean YH, Kang MI. Clinical signs and pathological lesions of foot-and-mouth disease in pigs, Korea. J Vet Clin 2004; 21: 172-176.
  5. Barnett PV, Cox SJ. The role of small ruminants in the epidemiology and transmission of foot-and-mouth disease. Vet J 1999; 158: 6-13. https://doi.org/10.1053/tvjl.1998.0338
  6. Chinsangaram J, Koster M, Grubman MJ. Inhibition of Ldeleted foot-and-mouth disease virus replication by alpha/beta interferon involves double-stranded RNA-dependent protein kinase. J Virol 2001; 75: 5498-5503. https://doi.org/10.1128/JVI.75.12.5498-5503.2001
  7. Donaldson AI, Kitching RP. Transmission of foot-and-mouth disease by vaccinated cattle following natural challenge. Res Vet Sci 1989; 46: 9-14.
  8. Duque H, Baxt B. Foot-and-mouth disease virus receptors: comparison of bovine alpha(V) integrin utilization by type A and O viruses. J Virol 2003; 77: 2500-2511. https://doi.org/10.1128/JVI.77.4.2500-2511.2003
  9. Falk MM, Sobrino F, Beck E. VPg gene amplification correlates with infective particle formation in foot-and-mouth disease virus. J Virol 1992; 66: 2251-2260.
  10. Grubman MJ, Moraes MP, Diaz-San Segundo F, Pena L, de los Santos T. Evading the host immune response: how foot-andmouth disease virus has become an effective pathogen. FEMS Immunol Med Microbiol 2008; 53: 8-17. https://doi.org/10.1111/j.1574-695X.2008.00409.x
  11. Jackson T, Blakemore W, Newman JW, Knowles NJ, Mould AP, Humphries MJ, King AM. Foot-and-mouth disease virus is a ligand for the high-affinity binding conformation of integrin alpha5beta1: influence of the leucine residue within the RGDL motif on selectivity of integrin binding. J Gen Virol 2000; 81: 1383-1391.
  12. Juleff N, Windsor M, Reid E, Seago J, Zhang Z, Monaghan P, Morrison IW, Charleston B. Foot-and-mouth disease virus persists in the light zone of germinal centres. PLoS One 2008; 3: e3434. https://doi.org/10.1371/journal.pone.0003434
  13. Mason PW, Grubman MJ, Baxt B. Molecular basis of pathogenesis of FMDV. Virus Res 2003; 91: 9-32. https://doi.org/10.1016/S0168-1702(02)00257-5
  14. Merono A, Lucena C, Lopez A, Garrido JJ, Perez de LL, Llanes D. Immunohistochemical analysis of beta3 integrin (CD61): expression in pig tissues and human tumors. Histol Histopathol 2002; 17: 347-352.
  15. Moon SH, Yang JS. Pathogenesis, Diagnosis, and Prophylactic Vaccine Development for Foot-and-Mouth Disease. J Korean Soc Appl Biol Chem 2005; 48: 301-310.
  16. Neff S, Mason PW, Baxt B. High-efficiency utilization of the bovine integrin alpha(v)beta(3) as a receptor for foot-andmouth disease virus is dependent on the bovine beta(3) subunit. J Virol 2000; 74: 7298-7306. https://doi.org/10.1128/JVI.74.16.7298-7306.2000
  17. Neff S, Sa-Carvalho D, Rieder E, Mason PW, Blystone SD, Brown EJ, Baxt B. Foot-and-mouth disease virus virulent for cattle utilizes the integrin alpha(v)beta3 as its receptor. J Virol 1998; 72: 3587-3594.
  18. Oem JK, Yeh MT, McKenna TS, Hayes JR, Rieder E, Giuffre AC, Robida JM, Lee KN, Cho IS, Fang X, Joo YS, Park JH. Pathogenic characteristics of the Korean 2002 isolate of footand- mouth disease virus serotype O in pigs and cattle. J Comp Pathol 2008; 138: 204-214. https://doi.org/10.1016/j.jcpa.2008.01.007
  19. Pacheco JM, Henry TM, O'Donnell VK, Gregory JB, Mason PW. Role of nonstructural proteins 3A and 3B in host range and pathogenicity of foot-and-mouth disease virus. J Virol 2003; 77: 13017-13027. https://doi.org/10.1128/JVI.77.24.13017-13027.2003
  20. Park JH, Lee KN, Kim SM, Ko YJ, Lee HS, Heo EJ, Kweon CH, Yang CH. The condition for air-borne transmission of footand- mouth disease. Kor J Vet Publ Hlth 2008; 32: 205-212.
  21. Park JH, Lee KN, Kim SM, Ko YJ, Lee HS, Heo EJ, Kweon CH, Yang CH. Role of persistent infection in the transmission of foot-and-mouth disease. Kor J Vet Publ Hlth 2008; 32: 189-197.
  22. Peng JM, Liang SM, Liang CM. VP1 of foot-and-mouth disease virus induces apoptosis via the Akt signaling pathway. J Biol Chem 2004; 279: 52168-52174. https://doi.org/10.1074/jbc.M403686200
  23. Pfaff E, Thiel HJ, Beck E, Strohmaier K, Schaller H. Analysis of neutralizing epitopes on foot-and-mouth disease virus. J Virol 1988; 62: 2033-2040.
  24. Sa-Carvalho D, Rieder E, Baxt B, Rodarte R, Tanuri A, Mason PW. Tissue culture adaptation of foot-and-mouth disease virus selects viruses that bind to heparin and are attenuated in cattle. J Virol 1997; 71: 5115-5123.
  25. Sakamoto K, Yoshida K. Pathogenicity of the Japanese isolate of foot-and-mouth disease virus, O/JPN/2000, to clovenhoofed animals. 2002. http://niah.naro.affrc.go.jp/publication/seikajoho2/2002/niah02025.html.
  26. Sanz-Parra A, Sobrino F, Ley V. Infection with foot-and-mouth disease virus results in a rapid reduction of MHC class I surface expression. J Gen Virol 1998: 79 (Pt 3): 433-436.
  27. Sobrino F, Domingo E. Foot and mouth disease current perspectives Horizon Bioscience, 2004; 173-222.
  28. Sobrino F, Saiz M, Jimenez-Clavero MA, Nunez JI, Rosas MF, Baranowski E, Ley V. Foot-and-mouth disease virus: a long known virus, but a current threat. Vet Res 2001; 32: 1-30. https://doi.org/10.1051/vetres:2001106
  29. Summerfield A, Guzylack-Piriou L, Harwood L, McCullough KC. Innate immune responses against foot-and-mouth disease virus. current understanding and future directions. Vet Immunol Immunopathol 2009; 128: 205-210. https://doi.org/10.1016/j.vetimm.2008.10.296
  30. Sur JH, Shin JH, Luobroth J, Yeh M, Ku BK, Choi KS, Kweon BJ, Sohn HJ, Ko YJ, Choi CU, Kwon CH, Kim JY, An SH, Kim KS, Moon OK, Kim JH, Choi SH, Lee HG, Hwang EK, Kim SB, Kang SS, Kim OK. In vivo characterization and transmission of Korean foot-and-mouth disease virus (FMDV). Korean J Vet Res 2000; 40: 719-727.
  31. Tai WC, Hsieh HJ, Wu MT. Hand, foot and mouth disease in a healthy adult caused by intrafamilial transmission of enterovirus 71. Br J Dermatol 2009; 160: 890-892. https://doi.org/10.1111/j.1365-2133.2009.09057.x