한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제28권1호
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  • Pages.28-32
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  • 2011
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

랫드에서 Sodium Hyaluronic Acid Solution과 가교처리한 Hyaluronic Acid Gel 혼합액의 복강내 유착 형성 방지 효과

The Preventive Effect of Sodium Hyaluronic Acid Solution and Crosslinked Hyaluronic Acid Mixture on Postoperative Intraperitoneal Adhesion Formation in Rats

  • 심사 : 2011.01.24
  • 발행 : 2011.02.28
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초록

This study was performed to evaluate the efficacy of 0.8% sodium hyaluronic acid solution and crosslinked hyaluronic acid mixture for the prevention of postoperative intraperitoneal adhesion in rats. Forty-five animals were divided into three groups ; 0.9% saline treated control group, 1% sodium carboxymethyl cellulose treated group (SCMC), and 0.8% sodium hyaluronic acid solution and crosslinked hyaluronic acid mixture treated group (SHCH). Adhesions were induced by suturing both the ileal serosa and peritoneum abrased until petechial bleeding occurred. Fourteen days later, adhesions were evaluated clinically and histopathologically. The mean tensile strength was significantly decreased in the SCMC and SHCH groups compared to the control group (p < 0.05), and the SHCH group had the lowest tensile strength. The distance of adhesion site was highest in the control group and significantly decreased in the SHCH group comparing control group (p < 0.05). The inflammatory cell infiltration, collagen hyperplasia and neovascularization of the SCMC and SHCH groups were significantly lower than the control group (p < 0.05). Therefore, it was concluded that the SHCH may be useful to prevent postoperative intraperitoneal adhesion in rats.

키워드

참고문헌

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