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기포군 영상분석을 통한 초음파 캐비테이션 현상의 변화 관찰

Ultrasonic Cavitation Effect Observation Using Bubble Cloud Image Analysis

  • Noh, Si-Cheol (Dept. of Radiological Science, International University of Korea) ;
  • Kim, Ju-Young (Dept. of Biomedical Engineering, Inje University) ;
  • Kim, Jin-Su (Dept. of Biomedical Engineering, Inje University) ;
  • Kang, Jung-Hoon (Dept. of Biomedical Engineering, Inje University) ;
  • Choi, Heung-Ho (Dept. of Biomedical Engineering, Inje University)
  • 투고 : 2010.12.07
  • 심사 : 2011.03.15
  • 발행 : 2011.03.31

초록

In this study, in order to evaluate the yield of bubble by ultrasonic cavitation in HIFU sonication, the bubble image analysis was performed. The changing phenomenon of cavitation effect according to the sonication condition was discussed by analyzing the bubble image. Especially the appearance of bubble cloud, the size of micro-bubble, and the yield of bubble were considered. The 500 KHz and 1.1 MHz concave type ultrasonic transducers were used for HIFU sonication. Computer controlled digital camera was used to obtain the bubble image, and the binary image processing(binarization coefficient : 0.15) was performed to analyze them. In results of 500 KHz and 1.1 MHz transducer, the area of bubble cloud was increased in proportion to the rise in sonication intensity($R^2$ : 0.7031 and 0.811). The mean size of single microbubble was measured as 98.18 um in 500 KHz sonication, and 63.38 um in 1.1 MHz sonication. In addition, the amount of produced bubble was increased in proportion to sonication intensity. Through the result of this study and further study for variable image processing method, the quantitative evaluation of ultrasonic cavitation effects in HIFU operation could be possible with the linearity associated with the sonication conditions.

키워드

참고문헌

  1. M. R. Bailey, V. A. Khokhlova, O. A. Sapozhnikov, et al.,“Physical mechanisms of the therapeutic effect ofultrasuond (A Review)”, Acoustic Physics, vol. 49, pp.437-464, 2003.
  2. Tinghe Yu, Shuhua Xiong, Timothy J. Mason, andZhibiao Wang, “The use of a microbubble agent toenhance rabbit liver destruction using high intensityfocused ultrasound”, Ultrasonics Sonochemistry, vol. 13,pp. 143-149, 2006. https://doi.org/10.1016/j.ultsonch.2005.02.001
  3. Yao-Sheng Tung, Hao-Li Liu, and Win-Li Lin,“Contrast-agent-enhanced ultrasound thermalablation”, Ultrasound in Med. & Biol., vol. 32, no. 7, pp.1103-1110, 2006 https://doi.org/10.1016/j.ultrasmedbio.2006.04.005
  4. Christopher E. Brennen, Cavitation and BubbleDynamics, Oxford University Press, New York, 11-13,91-95, 1995.
  5. 윤석왕 외, 물리음향학II, 아카넷, 서울, pp. 2-5, 26-28,2001.
  6. Tadeusz Gudra and Krzysztof J. Opielinski, “Applyingspectrum analysis and cepstrum analysis to examine thecavitation threshold in water and in salt solution”,Ultrasonics, vol. 42, pp. 621- 627, 2004. https://doi.org/10.1016/j.ultras.2003.11.016
  7. T. G. Leighton, The Acoustics Bubble, Academic Press,San Diego, 1994.
  8. http://www.sonicconcepts.com
  9. Christopher E. Brennen, Fundamentals of multiphaseflow, Cambridge Ltd 97-115.
  10. Hogn Chen, Xiaojing Li, and Mingxi Wan, “The inception of cavitation bubble clouds induced by highintensity focused ultrasound”, Ultrasonics, vol. 44, pp. 427-429, 2006. https://doi.org/10.1016/j.ultras.2006.05.021