Journal of Sensor Science and Technology (센서학회지)

The Korean Sensors Society (한국센서학회)
권호 표지
DOI QR코드

DOI QR Code

The Method of Measurement Signal Processing of Biosensor Based on Optical Fiber Using Reflected Localized Surface Plasmon Resonance

반사된 국소화 표면 플라즈몬 공명 신호를 이용한 광섬유기반 바이오센서의 측정 신호처리 방법

  • Jeong, Hyeon-Ho (Department of Electronics and Electrical Engineering, Dankook University) ;
  • Lee, Seung-Ki (Department of Electronics and Electrical Engineering, Dankook University)
  • 정현호 (단국대학교 전자전기공학부) ;
  • 이승기 (단국대학교 전자전기공학부)
  • Received : 2011.01.12
  • Accepted : 2011.03.09
  • Published : 2011.03.31
Download PDF
⟨ Previous Next ⟩

Abstract

LSPR(Localized Surface Plasmon Resonance) sensor measures the refractive index change on the sensor surface. The detection of biological reaction with the unknown refractive index needs to be converted into the signal sensitivity for the refractive index change for comparison with other measurements. To find the signal sensitivity, the three steps of signal processing are proposed, which are signal modeling, signal calibration and signal normalization of LSPR sensor. The detected signal of biotin-streptavidin interaction has been converted into unit of [RU](Resonance Unit) using the proposed method. The converted signal directly can be compared with the other sensors including commercialized one.

Keywords

References

  1. A. J. Haes and R. P. V. Duyne, “A unified view ofpropagating and localized surface plasmon resonancebiosensors”, Anal. and Bioanal. Chem., vol. 379, no. 7-8,pp. 980-983, 2004.
  2. B. Sepulveda, P. C. Angelome, L. M. Lechuga, and L. M.Liz-Marzan,“ LSPR-based nanobiosensors”, Nano today,vol. 4, Iss. 3, pp. 244-251, 2009. https://doi.org/10.1016/j.nantod.2009.04.001
  3. H. Lee and S. K. Lee, “Characterization of gold nanoparticleson optical fiber for localized surface plasmonresonance sensor”, J. Kor. Sensors Soc., vol. 18, no. 3,pp. 226-233, 2008.
  4. H. Lee, H. J. Kim, J. H. Park, D. H. Jeong, and S. K. Lee,“Effect of surface density and size of gold nanoparicles ina fiber-optic localized surface Plasmon resonance”,Meas. Sci. and Technol., 21 085805, pp. 1-9, 2010.
  5. B. H. Lee, S. K. Roh, and J. H. Park,“ Current status ofmicro- and nano-structured optical fiber sensors”,Optical Fiber Technol., vol. 15, Iss. 3, pp. 209-221, 2009. https://doi.org/10.1016/j.yofte.2009.02.006
  6. B. D. Gupta and R. K. Verma, “Surface plasmonresonance-based fiber optics sensors : principle, probedesigns, and some applications”, Journal of Sensors, vol.2009, article ID 979761, pp. 1-12, 2009.
  7. Y. Manaka, Y. Kudo, H. Yoshimine, T. Kawasaki, K.Kajikawa, and Y. Okahata, “Simultaneous anomalousreflection and quartz crystal microbalance measurementsof protein binding on a gold surface”, Chem. Commun.,35746, 2007. https://doi.org/10.1039/B708901E
  8. V. V. R. Sai, T. Kundu, and S. Mukjerji,“ Novel U-bentfiber optic probe for localized surface plasmon resonancebased biosensor”, Biosensors and Bioelectronics, vol. 24,Iss. 9, pp. 2804-2809, 2009 https://doi.org/10.1016/j.bios.2009.02.007
  9. K. Nagata and H. Handa, “Real-time analysis ofbiomolecular interactions”, Springer, pp. 23-187, 2000.
  10. H. Lee and S. K. Lee,“ Formation of metal nanoparticleson optical fiber for fiber optic localized surface plasmonresonance sensor”, J. Kor. Sensors Soc., vol. 17, no. 2,pp. 95-99, 2008. https://doi.org/10.5369/JSST.2008.17.2.095
  11. D. J. O'Shannessy, M. Brigham-Bruke and K. Peck,“Immobilization chemistries suitable for use in theBIAcore surface plasmon resonance detector”, Anal.Biochem., vol. 205, Iss. 1, pp. 132-136, 1992. https://doi.org/10.1016/0003-2697(92)90589-Y

Cited by

  1. Enzyme-coupled nanoplasmonic biosensing of cancer markers in human serum vol.81, 2016, https://doi.org/10.1016/j.bios.2016.03.009
  2. Fabrication of fiber-optic localized surface plasmon resonance sensor and its application to detect antibody-antigen reaction of interferon-gamma vol.50, pp.12, 2011, https://doi.org/10.1117/1.3662418
  3. Fiber-Optic Refractive Index Sensor Based on the Cone-Based Round Structure vol.13, pp.1, 2013, https://doi.org/10.1109/JSEN.2012.2216520
  4. PAME: plasmonic assay modeling environment vol.1, 2015, https://doi.org/10.7717/peerj-cs.17