Bulletin of the Korean Chemical Society

  • 제32권4호
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  • Pages.1209-1214
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  • 2011
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Synthesis and Antiproliferative Activity of Pyridinylcarbonylpyrimidines Against Melanoma Cell Line

  • Ahn, Hye-Mi (Life/Health Division, Korea Institute of Science and Technology) ;
  • Lee, Jun-A (Life/Health Division, Korea Institute of Science and Technology) ;
  • Kim, Hwan (Life/Health Division, Korea Institute of Science and Technology) ;
  • Oh, Chang-Hyun (Life/Health Division, Korea Institute of Science and Technology) ;
  • Lee, So-Ha (Life/Health Division, Korea Institute of Science and Technology) ;
  • Sim, Tae-Bo (Life/Health Division, Korea Institute of Science and Technology) ;
  • Hah, Jung-Mi (Department of Pharmacy, College of Pharmacy, Hanyang University) ;
  • Kim, Dong-Jin (Life/Health Division, Korea Institute of Science and Technology) ;
  • Yoo, Kyung-Ho (Life/Health Division, Korea Institute of Science and Technology)
  • 투고 : 2011.01.03
  • 심사 : 2011.02.07
  • 발행 : 2011.04.20
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초록

The synthesis of the series of pyrimidinylamines 1a-d and pyrimidinylureas 1e-u bearing a novel pyridinylcarbonylpyrimidine scaffold and their antiproliferative activities against A375 human melanoma cell line were described. Among them, three compounds 1e, 1h, and 1o showed superior antiproliferative activities to Sorafenib ($IC_{50}=5.5{\mu}M$) as a reference compound. In our series, urea compound 1o having 4-chloro-3-trifluoromethyl moiety on the benzene nucleus exhibited very good antiproliferative activity with $IC_{50}$ value of $1.4{\mu}M$.

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피인용 문헌

  1. ChemInform Abstract: Synthesis and Antiproliferative Activity of Pyridinylcarbonylpyrimidines Against Melanoma Cell Line. vol.42, pp.34, 2011, https://doi.org/10.1002/chin.201134160
  2. Synthetic Approaches to N ‐METHOXY‐ N ‐methylamides vol.42, pp.7, 2011, https://doi.org/10.1002/bkcs.12295