Case Report of a Breast Cancer Patient Treated with Adriamycin/5-Fluriuracil Regimen in Combination with Traditional Korean Medicine for Mitigating Side Effects

Adriamycin/5-Flurouracil 치료 중인 유방암 환자의 한.양방 병용치료를 통한 부작용 경감에 대한 증례보고

  • Kwon, Yong-Kyun (East-West Cancer Center, Dunsan Oriental Hospital of Dae-Jeon University) ;
  • Park, Jae-Woo (East-West Cancer Center, Dunsan Oriental Hospital of Dae-Jeon University) ;
  • Lee, Jong-Ho (East-West Cancer Center, Dunsan Oriental Hospital of Dae-Jeon University) ;
  • Yoo, Hwa-Seung (East-West Cancer Center, Dunsan Oriental Hospital of Dae-Jeon University) ;
  • Cho, Chong-Kwan (East-West Cancer Center, Dunsan Oriental Hospital of Dae-Jeon University) ;
  • Lee, Yeon-Weol (East-West Cancer Center, Dunsan Oriental Hospital of Dae-Jeon University)
  • 권용균 (대전대학교 둔산한방병원 동서암센터) ;
  • 박재우 (대전대학교 둔산한방병원 동서암센터) ;
  • 이종호 (대전대학교 둔산한방병원 동서암센터) ;
  • 유화승 (대전대학교 둔산한방병원 동서암센터) ;
  • 조종관 (대전대학교 둔산한방병원 동서암센터) ;
  • 이연월 (대전대학교 둔산한방병원 동서암센터)
  • Published : 2011.12.30

Abstract

Objectives : To observe the mitigating effects of a Traditional Korean Medicine treatment program, called Wheel Balanced Cancer Therapy (WBCT), with Adriamycin and 5-FU chemotherapy on a breast cancer patient. Methods : A 26 year old female patient diagnosed with stage IIb breast cancer was admitted to the East-West Cancer Center (EWCC) in February of 2010. She received Adriamycin and 5-FU from February 22nd, to July 20th, 2010 followed by WBCT consisting of herbal medicine, acupuncture, moxibustion and physiotherapy for 5 months. Her symptoms were measured by Common Terminology Criteria for Adverse Events (CTCAE) and her quality of life was measured by Eastern Cooperative Oncology Group (ECOG). Results : WBCT significantly alleviated chemotherapy-induced nausea, oral dryness, and peripheral neuropathy. Quality of life also significantly improved. Conclusions : This case study potentiates WBCT's significant efficacy in aiding breast cancer patients suffering from Adriamycin plus 5-FU chemotherapy induced adverse effects.

Keywords

References

  1. 보건복지부 중앙암등록본부. 2008년 국가암등록 통계. 중앙암등록본부; 2010, p. 10. [E-book] Available from: http://www.cancer.go.kr/ncic/cics_g/cics_g02/cics_g027/1434914_6065.html
  2. Jung KH. Special Review : Personalized therapy for advanced breast cancer using molecular signatures. Korean J Med 2009;77(1):26-34.
  3. Berry DA, Cronin KA, Plevritis SK, Fryback DG, Clarke L, Zelen M, et al.. Cancer Intervention and Surveillance Modeling Network (CISNET) Collaborators. Effect of screening and adjuvant therapy on mortality from breast cancer. N Engl J Med 2005;353(17):1784-92. https://doi.org/10.1056/NEJMoa050518
  4. Dodd MJ, Miaskowski C, Paul SM. Symptom clusters and their effect on the functional status of patients with cancer. Oncol Nurs Forum 2001;28(3):465-70.
  5. Lee HY, Park HJ. Prevention and treatment of postoperative nausea and vomiting. J Korean Med Assoc 2007;50(1):65-70. https://doi.org/10.5124/jkma.2007.50.1.65
  6. Jacobson JS, Workman SB, Kronenberg F. Research on complementary/alternative medicine for breast cancer : A review of the biomedical literature. J Clin Oncol 2000;18(3):668-83.
  7. Zheng HM. Evidence Based Approach of Wheel Balance Cancer Therapy; A Review. 학위논문(석사). 대전대학교 2011.
  8. Park HM, Kim SY, Jung IC, Lee YW, Cho CK, Yoo HS. Integrative tumor board: a case report and discussion from East-West Cancer Center. Integr Cancer Ther 2010;9(2):236-45. https://doi.org/10.1177/1534735410371479
  9. Giantonio BJ, Forastiere AA, Comis RL. The role of the Eastern Cooperative Oncology Group in establishing standards of cancer care: over 50 years of progress through clinical research. Semin Oncol 2008;35(5):494-506. https://doi.org/10.1053/j.seminoncol.2008.07.004
  10. Hassan BA, Yusoff ZB. Negative impact of chemotherapy on breast cancer patients QOL - utility of antiemetic treatment guidelines and the role of race. Asian Pac J Cancer Prev. 2010;11(6):1523-7.
  11. Cha KY, Kim HA, Moon BI, Choe KJ, Choi KJ, Suh HS, et al. Toxicity of Concurrent Adjuvant CMF Chemotherapy and Radiotherapy in Patients with Early Breast Cancer. J Breast Cancer 2007;June 10(2):147-52. https://doi.org/10.4048/jbc.2007.10.2.147
  12. Woo HD, Kim HS, Lee JH, Kim HM, Han SW, Kim SY, et al. Toxicity and Tolerability Study of Adjuvant TAC Regimen Chemotherapy in Korean Patients with Breast Cancer. J Breast Cancer 2011;Feb 14(S):44-9. https://doi.org/10.4048/jbc.2011.14.S.S44