Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Screening of Herbal Medicines from China with Inhibitory Activity on Advanced Glycation End Products (AGEs) Formation (V)

중국산 약용식물의 최종당화산물 생성저해활성 검색 (V)

  • Kim, Young-Sook (Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine) ;
  • Choi, Sung-Hoon (Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine) ;
  • Kim, Joo-Hwan (Department of Life Science, Kyungwon University) ;
  • Kim, Jin-Sook (Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine)
  • 김영숙 (한국한의학연구원 한의융합연구본부 당뇨합병증연구센터) ;
  • 최성훈 (한국한의학연구원 한의융합연구본부 당뇨합병증연구센터) ;
  • 김주환 (경원대학교 생명과학과) ;
  • 김진숙 (한국한의학연구원 한의융합연구본부 당뇨합병증연구센터)
  • Received : 2011.01.25
  • Accepted : 2011.03.03
  • Published : 2011.03.31
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Abstract

Advanced glycation end products (AGEs) have been postulated to play a central role in the development of diabetic complications. A variety of different agents that inhibit AGEs have been under investigation. In this study, 66 herbal medicines from China have been investigated with an in vitro evaluation system using AGEs formation inhibitory activity. Of these, 31 herbal medicines ($IC_{50}$ < $50\;{\mu}g/ml$) were found to have significant AGEs formation inhibitory activity. Particularly, 5 herbal medicines, Camptotheca acuminata (branches and leaves), Quercus franchetii (branches), Camellia pitardii (leaves, branches, and fruits), Antidesma bunius (whole plants), and Loranthus parasiticus (whole plants) showed more potent inhibitory activity (approximately 6-20 fold) than the positive control aminoguanidine ($IC_{50}=52.96\;{\mu}g/ml$).

Keywords

References

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