Journal of the Korean Society of Industry Convergence (한국산업융합학회 논문집)
- Volume 14 Issue 3
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- Pages.105-111
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- 2011
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- 1226-833X(pISSN)
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- 2765-5415(eISSN)
DOI QR Code
Detection of Landmark Spots for Spot Matching in 2DGE
2차원 전기영동 영상의 스팟 정합을 위한 Landmark 스팟쌍의 검출
- Han, Chan-Myeong (Gyungbuk Institute of IT Convergence Industry Technology) ;
- Suk, Soo-Young (Gyungbuk Institute of IT Convergence Industry Technology) ;
- Yoon, Young-Woo (Department of Computer Engineering, Yeungnam Univ.)
- Received : 2011.05.24
- Accepted : 2011.08.24
- Published : 2011.08.31
Abstract
Landmark Spots in 2D gel electrophoresis are used in many methods of 2DEG spot matching. Landmark Spots are obtained manually and it is a bottle neck in the entire protein analysis process. Automated landmark spots detection is a very crucial topic in processing a massive amount of 2DGE data. In this paper, Automated landmark spot detection is proposed using point pattern matching and graph theory. Neighbor spots are defined by a graph theory to use and only a centered spot and its neighbor spots are considered for spot matching. Normalized Hausdorff distance is introduced as a criterion for measuring degree of similarity. In the conclusion, the method proposed in this paper can get about 50% of the total spot pairs and the accuracy rate is almost 100%, which the requirements of landmark spots are fully satisfied.
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