Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • 제37권6호
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  • Pages.470-476
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  • 2011
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  • 2234-7550(pISSN)
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  • 2234-5930(eISSN)
대한구강악안면외과학회 (The Korean Association of Oral and Maxillofacial Surgeons)
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비스포스포네이트 관련 악골괴사에 대한 후향적 연구

Retrospective study on the bisphosphonate-related osteonecrosis of jaw

  • 한윤식 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 이인우 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 이호 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 서진원 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 김성민 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 명훈 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 황순정 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 최진영 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 이종호 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 정필훈 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 김명진 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 서병무 (서울대학교 치의학대학원 구강악안면외과학교실)
  • Han, Yoon-Sic (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Lee, In-Woo (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Lee, Ho (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Suh, Jin-Won (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Kim, Soung-Min (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Myoung, Hoon (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Hwang, Soon-Jung (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Choi, Jin-Young (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Lee, Jong-Ho (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Choung, Pill-Hoon (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Kim, Myung-Jin (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Seo, Byoung-Moo (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University)
  • 투고 : 2011.08.23
  • 심사 : 2011.11.01
  • 발행 : 2011.12.31
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초록

Introduction: The incidence of bisphosphonate-related osteonecrosis of the jaw (BRONJ) has increased gradually in patients who have undergone surgical treatment for osteomyelitis. In this study, a retrospective analysis of BRONJ patients was carried out using the data of osteomyelitis patients treated surgically. Materials and Methods: Osteomyelitis patients, who underwent curettage, sequestrectomy, saucerization or decortications, and partial mandibulectomy at Seoul National University Dental Hospital from 2004 to 2010 were enrolled in this study. The patients were classified and categorized into two groups based on the surgical records and progress notes. One group comprised of patients with osteomyelitis and osteoporosis, and the other group included patients with osteomyelitis only. The epidemiological data of the BRONJ patients was analyzed to identify any trend in the incidence of BRONJ in osteomyelitis patients. Results: Among 200 patients who underwent surgical intervention for osteomyelitis, 64 (32.0%) were identified as having osteoporosis as the underlying disease. In these 64 patients, more than 81.3% had been prescribed bisphosphonates. Females were far more affected by BRONJ than males. The incidence of BRONJ also increased with age. The posterior part of the mandible was affected more frequently by BRONJ. Conclusion: Although the availability of potent antibiotics and increased oral hygiene care can reduce the overall incidence of osteomyelitis, BRONJ can increase the total incidence. To prevent BRONJ, it is recommended that an oral examination be performed before prescribing bisphosphonates. Moreover, the patients should be educated about the potential risks of dental procedures that might be causal factors for BRONJ. Furthermore, patient swho take bisphosphonates for the treatment of osteoporosis should undergo periodic follow up oral examinations to prevent BRONJ.

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참고문헌

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피인용 문헌

  1. 종설 : 치과위생사가 알아야 할 골다공증과 골 관련 사이토카인 vol.3, pp.2, 2020, https://doi.org/10.22753/jkdhs/2020.3.2.59