Mycobiology

  • 제39권4호
  • /
  • Pages.283-289
  • /
  • 2011
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  • 1229-8093(pISSN)
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  • 2092-9323(eISSN)
한국균학회 (The Korean Society of Mycology)
권호 표지
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DOI QR Code

Appraisal of Antihyperlipidemic Activities of Lentinus lepideus in Hypercholesterolemic Rats

  • Yoon, Ki-Nam (Division of Life Sciences, University of Incheon) ;
  • Lee, Jae-Seong (Division of Life Sciences, University of Incheon) ;
  • Kim, Hye-Young (Division of Life Sciences, University of Incheon) ;
  • Lee, Kyung-Rim (Division of Life Sciences, University of Incheon) ;
  • Shin, Pyung-Gyun (Mushroom Division, National Institute of Horticultural and Herbal Science, Rural Development Administration) ;
  • Cheong, Jong-Chun (Mushroom Division, National Institute of Horticultural and Herbal Science, Rural Development Administration) ;
  • Yoo, Young-Bok (Mushroom Division, National Institute of Horticultural and Herbal Science, Rural Development Administration) ;
  • Alam, Nuhu (Department of Botany, Jahangirnagar University) ;
  • Ha, Tai-Moon (Mushroom Research Institute, Geonggi Agricultural Research and Extension Service) ;
  • Lee, Tae-Soo (Division of Life Sciences, University of Incheon)
  • 투고 : 2011.11.07
  • 심사 : 2011.11.09
  • 발행 : 2011.12.31
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초록

The wild edible mushroom, Lentinus lepideus has recently been cultivated for commercial use in Korea. While the mushroom has been widely used for nutritional and medicinal purposes, the possible anti-hyperlipidemic action is unclear. The effects of dietary L. lepideus on plasma and feces biochemical and on the liver histological status were investigated in hypercholesterolemic rats. Six-wk-old female Sprague-Dawley albino rats were divided into three groups of 10 rats each. Biochemical and histological examinations were performed. A diet containing 5% L. lepideus fruiting bodies reduced plasma total cholesterol, triglyceride, low-density lipoprotein, total lipid, phospholipids, and the ratio of low-density to high-density lipoprotein. Body weight was reduced. The diet did not adversely affect plasma biochemical and enzyme profiles. L. lepideus reduced significantly plasma ${\beta}$- and pre-${\beta}$-lipoprotein, while ${\alpha}$-lipoprotein content was increased. A histological study of hepatic cells by conventional hematoxylin-eosin and oil red O staining revealed normal findings for mushroom-fed hypercholesterolemic rats. The present study suggests that a diet supplemented with L. lepideus can provide health benefits by acting on the atherogenic lipid profile in hypercholesterolemic rats.

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참고문헌

  1. Hibbett DS, Vilgalys R. Phylogenetic relationships of Lentinus (Basidiomycotina) inferred from molecular and morphological characters. Syst Bot 1993;18:409-33. https://doi.org/10.2307/2419417
  2. Mattila P, Konko K, Eurola M, Pihlava JM, Astola J, Vahteristo L, Kumpulainen J, Valtonen M, Pironen V. Contents of vitamins, mineral elements, and some phenolic compounds in cultivated mushrooms. J Agric Food Chem 2001;49:2343-8. https://doi.org/10.1021/jf001525d
  3. Alam N, Yoon KN, Lee KR, Shin PG, Cheong JC, Yoo YB, Shim MJ, Lee MW, Lee UY, Lee TS. Antioxidant activities and tyrosinase inhibitory effects of different extracts from Pleurotus ostreatus fruiting bodies. Mycobiology 2010;38:295-301. https://doi.org/10.4489/MYCO.2010.38.4.295
  4. Gunde-Cimerman N, Plemenitas A, Cimerman A. Pleurotus fungi produce mevinolin, an inhibitor of HMG CoA reductase. FEMS Microbiol Lett 1993;113:333-7. https://doi.org/10.1111/j.1574-6968.1993.tb06536.x
  5. Alam N, Amin R, Khan A, Ara I, Shim MJ, Lee MW, Lee UY, Lee TS. Comparative effects of oyster mushrooms on lipid profile, liver and kidney function in hypercholesterolemic rats. Mycobiology 2009;37:37-42. https://doi.org/10.4489/MYCO.2009.37.1.037
  6. Fukushima M, Ohashi T, Fujiwara Y, Sonoyama K, Nakano M. Cholesterol-lowering effects of maitake (Grifola frondosa) fiber, shiitake (Lentinus edodes) fiber, and enokitake (Flammulina velutipes) fiber in rats. Exp Biol Med (Maywood) 2001;226:758-65. https://doi.org/10.1177/153537020222600808
  7. Susuki S, Oshima S. Influence of shiitake, Lentinus edodes, on human serum cholesterol. Ann Rep Natl Inst Nutr 1974;25:89-94.
  8. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. https://doi.org/10.3177/jnsv.35.91
  9. Sugiyama K, Yamakawa A. Dietary eritadenine-induced alteration of molecular species composition of phospholipids in rats. Lipds 1996;31:399-404. https://doi.org/10.1007/BF02522926
  10. Burtis CA, Ashwood ER. Tietz fundamentals of clinical chemistry. New Delhi: Reed Elsevier India Private Ltd.; 2006.
  11. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957;226:497-509.
  12. Kido T, Kurata H, Matsumoto A, Tobiyama R, Musha T, Hayashi K, Tamai S, Utsunomiya K, Tajima N, Fidge N, et al. Lipoprotein analysis using agarose gel electrophoresis and differential staining of lipids. J Atheroscler Thromb 2001;8:7-13. https://doi.org/10.5551/jat1994.8.7
  13. Bayliss HO. Lipids. In: Bancroft JD, Stevens A, editors. Theory and practice of histological techniques. Edinburgh: Churchill Livingstone; 1990. p. 215-44.
  14. Andrus SB, Fillios LC, Mann GV, Stare FJ. Experimental production of gross atherosclerosis in the rat. J Exp Med 1956;104:539-54. https://doi.org/10.1084/jem.104.4.539
  15. Fujioka T, Nara F, Tsujita Y, Fukushige J, Fukami M, Kuroda M. The mechanism of lack of hypocholesterolemic effects of pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in rats. Biochim Biophys Acta 1995;1254:7-12. https://doi.org/10.1016/0005-2760(94)00154-Q
  16. Roach PD, Balasubramaniam S, Hirata F, Abbey M, Szanto A, Simons LA, Nestel PJ. The low-density lipoprotein receptor and cholesterol synthesis are affected differently by dietary cholesterol in the rat. Biochim Biophys Acta 1993;1170:165-72. https://doi.org/10.1016/0005-2760(93)90067-J
  17. Dolphin PJ, Forsyth SJ. Nascent hepatic lipoproteins in hypothyroid rats. J Lipid Res 1983;24:541-51.
  18. Uchida K, Satoh T, Chikai T, Takase H, Nomura Y, Nakao H, Takeuchi N. Influence of cholesterol feeding on bile acid metabolism in young and aged germ-free rats. Jpn J Pharmacol 1996;71:113-8. https://doi.org/10.1254/jjp.71.113
  19. Bobek P, Hromadova M, Ozdin L. Oyster mushroom (Pleurotus ostreatus) reduces the activity of 3-hydroxy-3-methylglutaryl CoA reductase in rat liver microsomes. Experientia 1995;51:589-91. https://doi.org/10.1007/BF02128749
  20. Alarcon J, Aguila S, Arancibia-Avila P, Fuentes O, Zamorano-Ponce E, Hernandez M. Production and purification of statins from Pleurotus ostreatus (Basidiomycetes) strains. Z Naturforsch C 2003;58:62-4.
  21. Alam N, Yoon KN, Lee TS, Lee UY. Hypolipidemic activities of dietary Pleurotus ostreatus in hypercholesterolemic rats. Mycobiology 2011;39:45-51. https://doi.org/10.4489/MYCO.2011.39.1.045
  22. Mayes PA. Metabolism of lipids. In: Harper HA, Rodwell VW, Mayes PA, editors. Reviews of physiological chemistry. Los Altos: Lange Publications; 1997. p. 280-321.
  23. Yang BK, Jung YS, Song CH. Hypoglycemic effects of Ganoderma applanatum and Collybia confluens exo-polymers in streptozotocin-induced diabetic rats. Phytother Res 2007;21:1066-9. https://doi.org/10.1002/ptr.2214
  24. Jude IC, Catherine IC, Frank OC. Effect of aqueous extract of Tridax procumbens Linn on plasma electrolytes of salt-loaded rats. Pak J Nutr 2010;9:103-5. https://doi.org/10.3923/pjn.2010.103.105
  25. Antonov AR, Efremov AV, Letiagina VV, Nacharov YuV, Markel' AL, Yakobson GS. Plasma and lymph electrolyte and endocrine parameters in rats with genetically-determined arterial hypertension. Bull Exp Biol Med 1997;7:652-4.
  26. Bobek P, Ozdin L, Kuniak L. Effect of oyster mushroom (Pleurotus ostreatus) and its ethanolic extract in diet on absorption and turnover of cholesterol in hypercholesterolemic rat. Nahrung 1996;40:222-4. https://doi.org/10.1002/food.19960400413
  27. Keim NL, Marlett JA, Amundson CH, Hagemann LD. Comparison of rat hepatic cholesterol biosynthesis during skim milk versus whey permeate ingestion. J Dairy Sci 1982;65:2274-80. https://doi.org/10.3168/jds.S0022-0302(82)82497-1
  28. Li H, Zhang M, Ma G. Hypolipidemic effect of the polysaccharide from Pholiota nameko. Nutrition 2010;26:556-62. https://doi.org/10.1016/j.nut.2009.06.009
  29. Bobek P, Galbavy S. Hypocholesterolemic and antiatherogenic effect of oyster mushroom (Pleurotus oszmsdtreatus) in rabbits. Nahrung1999;43:339-42. https://doi.org/10.1002/(SICI)1521-3803(19991001)43:5<339::AID-FOOD339>3.0.CO;2-5