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Erythema Multiforme and Stevens-Johnson Syndrome : Case Reports

다형홍반과 스티븐스-존슨 신드롬의 증례보고

  • Jung, Won (Department of Oral medicine, School of Dentistry, Chonbuk National University) ;
  • Lee, Kyung-Eun (Department of Oral medicine, School of Dentistry, Chonbuk National University) ;
  • Byun, Jin-Seok (Graduate School of Medical Science and Engineering, KAIST) ;
  • Suh, Bong-Jik (Department of Oral medicine, School of Dentistry, Chonbuk National University)
  • 정원 (전북대학교 치의학전문대학원 구강내과학교실) ;
  • 이경은 (전북대학교 치의학전문대학원 구강내과학교실) ;
  • 변진석 (한국과학기술원 의과학연구센터) ;
  • 서봉직 (전북대학교 치의학전문대학원 구강내과학교실)
  • Received : 2011.09.26
  • Accepted : 2011.11.18
  • Published : 2011.12.30

Abstract

Painful, ulcerative lesions of various systemic disease can affect the oral mucosa membrane at first. If you don't consider the skin lesion, followed or accompanied by oral mucosa, you are likely to fail in differential diagnosis. In this cases, we introduced erythema multiforme and Stevens-Johnson syndrome(SJS) patients with painful, ulcerative lesions on oral mucosa and skin. Also we review oral mucosal diseases come with the skin lesions.

구강 점막에 발생하는 동통성 궤양은 다양한 질환에 의해 발생할 수 있다. 구강내 병소가 발생한 후 피부병소가 발생하는 질환 또는 구강과 피부 동시에 병소가 발생하는 질환의 경우, 구강내만 국한하여 검사를 시행하고 피부 병소를 간과할 때는 진단이 어려울 수 있다. 본 증례에서는 구강 및 전신에 발생한 통증성, 미란성 병소가 나타나는 다형홍반 및 Stevens-Johnson syndrome(SJS) 환자를 경험하여 이를 보고하고 피부병소가 동반되는 구강점막 질환에 대해 고찰해 보고자 한다.

Keywords

References

  1. Oliveira LR, Zucoloto S. Erythema Multiforme Minor: A Revision. American Journal of Infectious Disease 2008;4:224-231 https://doi.org/10.3844/ajidsp.2008.224.231
  2. Auquier-Dunant A, Mockenhaupt M, Naldi L. et al. Correlations Between Clinical Patterns and Causes of Erythema Multiforme Majus, Stevens-Johnson Syndrome, and Toxic Epidermal Necrolysis. Arch Dermatol 2002;138:1019-1024 https://doi.org/10.1001/archderm.138.8.1019
  3. 대한피부과학회 교과서 편찬 위원회. 피부과학. 5판. 서울. 2008. 도서출판 여문각. pp.221-227.
  4. Bastuji-Garin S, Rzany B, Stern RS, Shear NH, Naldi L, Roujeau JC. Clinical Clssification of Cases of Toxic Epedermal Necrolysis, Stevens-Johnson Syndrome, and Erythema Multiforme. Arch Dermatol 1993;129:92-96 https://doi.org/10.1001/archderm.1993.01680220104023
  5. Weston WL, Morelli JG, Rogers M. Target lesions on the lips: Childhood herpes simplex associated with erythema multiforme mimics Stevens-Johnson syndrome. J Am Acad Dermatol 1997;37:848-850 https://doi.org/10.1016/S0190-9622(97)80009-6
  6. Harr T, French Le. Toxic Epidermal Necrolysis and Stevens-Johnson syndrome. Orphanet Journal of Rare Diseases 2010;5-39
  7. Shetty SR, Chatra L, Shenai P, Rao PK. Stevens-Johnson syndrome: a case report. Journal of Oral Science 2010;52:343-346 https://doi.org/10.2334/josnusd.52.343
  8. Scully C, Felix DH. Oral Medicine - Update for the dental practitioner. Mouth ulcers of more serious connotation. British Dental Journal 2005;199:339-343 https://doi.org/10.1038/sj.bdj.4812805
  9. 홍성주, 강승우, 안종모. 구강에 발생한 급성 및 만성 궤양성 병소의 치료 : 증례보고. 대한구강내과학회지 2009;34:55-62
  10. Grattan CE, Scully C. Oral ulceration: a diagnostic problem. British Medical Journal 1986;292:1093-1094 https://doi.org/10.1136/bmj.292.6528.1093
  11. 이종선, 윤숙정, 김성진 등. 자가면역 수포성 질환의 임상 및 역할적 고찰. 대한피부과학회지 2008;46(2):189-195
  12. Fadi AA, Javier AA. Pemphigus vulgaris and mucous membrane pemphigoid: Update on etiopathogenesis, oral manifestations and management. J Clin Exp Dent 2011;3(3):e246-50
  13. Black M, Mignongna MD, Scully C. Mucosal Diseases Series Number II Pemphigus vulargis. Oral Diseases 2005;11:119-130
  14. Bagan J, Lo Muzio L, Scully C. Mucosal Diseases Series Number III Mucous membrane pemphigoid. Oral Diseases 2005;11:197-218 https://doi.org/10.1111/j.1601-0825.2005.01140.x
  15. Roopashree MR, Gondhalekar RV, Shashikanth MC, George J, Thippeswamy SH, Shukla A. Pathogenesis of oral lichen planus - a review. J Oral Pathol Med 2010;39:729-734 https://doi.org/10.1111/j.1600-0714.2010.00946.x
  16. 김대석, 방동식. 구강편평태선 35예의 임상적 고찰. 대한피부과학회지 2007;45(1):1-8
  17. Scully C, Bagan J. Oral mucosal diseases: Erythema multiforme. British Journal of Oral and Maxillofacial Surgery 2008;46(2):90-95 https://doi.org/10.1016/j.bjoms.2007.07.202
  18. Kokuba H, Aurelian L, Burnett J. Herpes Simplex Virus Associated Erythema Multiforme(HAEM) is Mechanstically Distinct from Drug-Induced Erythea Multiforme: Interferon-$\gamma$ is Expressed in HAEM Lesions and Tumor Necrosis Factor-$\alpha$ in Drug-Induced Erythema Multiforme Lesions. J Invest Dermatol 1999;113:808-815 https://doi.org/10.1046/j.1523-1747.1999.00754.x
  19. Del Pozzo-Magana BR, Lazo-Langner A, Carleton B, Castro-Pastrana LI, Rieder MJ. A Systematic Review of Treatment of Drug-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Children. J Popul Ther Cllin Pharmacol 2011;18:e121-e133