DOI QR코드

DOI QR Code

Comparison of Resistance to ${\gamma}$-Irradiation between Cryptosporidium parvum and Cryptosporidium muris Using In Vivo Infection

  • Yoon, Se-Joung (Department of Environmental and Tropical Medicine, Konkuk University, School of Medicine) ;
  • Yu, Jae-Ran (Department of Environmental and Tropical Medicine, Konkuk University, School of Medicine)
  • 투고 : 2011.08.01
  • 심사 : 2011.09.26
  • 발행 : 2011.12.15

초록

In the genus Cryptosporidium, there are more than 14 species with different sizes and habitats, as well as different hosts. Among these, C. parvum and C. hominis are known to be human pathogens. As C. parvum can survive exposure to harsh environmental conditions, including various disinfectants or high doses of radiation, it is considered to be an important environmental pathogen that may be a threat to human health. However, the resistance of other Cryptosporidium species to various environmental conditions is unknown. In this study, resistance against ${\gamma}$-irradiation was compared between C. parvum and C. muris using in vivo infection in mice. The capability of C. muris to infect mice could be eliminated with 1,000 Gy of ${\gamma}$-irradiation, while C. parvum remained infective in mice after up to 1,000 Gy of ${\gamma}$-irradiation, although the peak number of oocysts per gram of feces decreased to 16% that of non-irradiated oocysts. The difference in radioresistance between these 2 Cryptosporidium species should be investigated by further studies.

키워드

참고문헌

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피인용 문헌

  1. Recombinant thioredoxin peroxidase from Cryptosporidium parvum has more powerful antioxidant activity than that from Cryptosporidium muris vol.131, pp.3, 2011, https://doi.org/10.1016/j.exppara.2012.04.018