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Supratentorial Clear Cell Ependymoma Mimicking Oligodendroglioma : Case Report and Review of the Literature

  • Lee, Byoung-Hun (Department of Neurosurgery, Chung-Ang University College of Medicine) ;
  • Kwon, Jeong-Taik (Department of Neurosurgery, Chung-Ang University College of Medicine) ;
  • Park, Yong-Sook (Department of Neurosurgery, Chung-Ang University College of Medicine)
  • Received : 2011.04.18
  • Accepted : 2011.08.30
  • Published : 2011.09.28

Abstract

Clear cell ependymomas (CCEs) are rare variants of ependymomas. Tumors show anaplastic histological features and behave as an aggressive manner. CCEs have a predilection for extraneural metastases and early recurrence, and they demonstrate characteristic radiographic features. These tumors should be radiologically and pathologically differentiated from oligodendrogliomas. On microscopic examination, CCEs are composed of sheets of cells and resemble oligodendroglioma. However, upon closer examination, the nature of CCEs can be detected earlier, resulting in prompt treatment of the tumor. Although we report only one case, we emphasize the importance of early diagnosis and treatment. Future description of more cases of these rare cancers is necessary to aid in their diagnosis and treatment.

Keywords

References

  1. Amatya VJ, Takeshima Y, Kaneko M, Nakano T, Yamaguchi S, Sugiyama K, et al. : Case of clear cell ependymoma of medulla oblongata : clinicopathological and immunohistochemical study with literature review. Pathol Int 53 : 297-302, 2003 https://doi.org/10.1046/j.1440-1827.2003.01470.x
  2. Fokes EC Jr, Earle KM : Ependymomas : clinical and pathological aspects. J Neurosurg 30 : 585-594, 1969 https://doi.org/10.3171/jns.1969.30.5.0585
  3. Fouladi M, Helton K, Dalton J, Gilger E, Gajjar A, Merchant T, et al. : Clear cell ependymoma : a clinicopathologic and radiographic analysis of 10 patients. Cancer 98 : 2232-2244, 2003 https://doi.org/10.1002/cncr.11783
  4. Gilbert MR, Ruda R, Soffietti R : Ependymomas in adults. Curr Neurol Neurosci Rep 10 : 240-247, 2010 https://doi.org/10.1007/s11910-010-0109-3
  5. Jain D, Sharma MC, Arora R, Sarkar C, Suri V : Clear cell ependymoma : a mimicker of oligodendroglioma-report of three cases. Neuropathology 28 : 366-371, 2008 https://doi.org/10.1111/j.1440-1789.2008.00895.x
  6. Kawano N, Yada K, Aihara M, Yagishita S : Oligodendroglioma-like cells (clear cells) in ependymoma. Acta Neuropathol 62 : 141-144, 1983 https://doi.org/10.1007/BF00684931
  7. Kim JH, Cho BK, Kim IO, Park SH : Clear-cell ependymoma of the cerebellum : a case report. Ultrastruct Pathol 31 : 241-247, 2007 https://doi.org/10.1080/01913120701446841
  8. Kim NR, Chung DH, Lee SK, Ha SY : Intramedullary clear cell ependymoma in the thoracic spinal cord : a case with its crush smear and ultrastructural findings. J Korean Med Sci 22 : S149-S153, 2007 https://doi.org/10.3346/jkms.2007.22.S.S149
  9. Kleihues P, Burger PC, Scheithauer BW : The new WHO classification of brain tumours. Brain Pathol 3 : 255-268, 1993 https://doi.org/10.1111/j.1750-3639.1993.tb00752.x
  10. Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC, et al. : The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol 61 : 215-225; discussion 226-229, 2002 https://doi.org/10.1093/jnen/61.3.215
  11. Liu HM, McLone DG, Clark S : Ependymomas of childhood. II. Elctron-microscopic study. Childs Brain 3 : 281-296, 1977
  12. Mack SC, Taylor MD : The genetic and epigenetic basis of ependymoma. Childs Nerv Syst 25 : 1195-1201, 2009 https://doi.org/10.1007/s00381-009-0928-1
  13. Metellus P, Guyotat J, Chinot O, Durand A, Barrie M, Giorgi R, et al. : Adult intracranial who grade II ependymomas : long-term outcome and prognostic factor analysis in a series of 114 patients. Neuro Oncol 12 : 976-984, 2010 https://doi.org/10.1093/neuonc/noq047
  14. Min KW, Scheithauer BW : Clear cell ependymoma : a mimic of oligodendroglioma : clinicopathologic and ultrastructural considerations. Am J Surg Pathol 21 : 820-826, 1997 https://doi.org/10.1097/00000478-199707000-00010
  15. Niazi TN, Jensen EM, Jensen RL : WHO grade II and III supratentorial hemispheric ependymomas in adults : case series and review of treatment options. J Neurooncol 91 : 323-328, 2009 https://doi.org/10.1007/s11060-008-9717-z
  16. Oya N, Shibamoto Y, Nagata Y, Negoro Y, Hiraoka M : Postoperative radiotherapy for intracranial ependymoma : analysis of prognostic factors and patterns of failure. J Neurooncol 56 : 87-94, 2002 https://doi.org/10.1023/A:1014442106111
  17. Suh JH, Hong SM, Lee IC : Clear cell ependymoma. Korean J Pathol 31 : 383-387, 1997
  18. Svien HJ, Mabon RF, Kernohan JW, Craig WM : Ependymoma of the brain; pathologic aspects. Neurology 3 : 1-15, 1953 https://doi.org/10.1212/WNL.3.1.01

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