Clinical and Experimental Reproductive Medicine

  • 제38권1호
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  • Pages.42-46
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  • 2011
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  • 2233-8233(pISSN)
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  • 2233-8241(eISSN)
대한생식의학회 (The Korean Society for Reproductive Medicine)
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Endometrial histology and predictable clinical factors for endometrial disease in women with polycystic ovary syndrome

  • Park, Joon-Cheol (Department of Obstetrics and Gynecology, Keimyung University School of Medicine) ;
  • Lim, Su-Yeon (Department of Obstetrics and Gynecology, Keimyung University School of Medicine) ;
  • Jang, Tae-Kyu (Department of Obstetrics and Gynecology, Keimyung University School of Medicine) ;
  • Bae, Jin-Gon (Department of Obstetrics and Gynecology, Keimyung University School of Medicine) ;
  • Kim, Jong-In (Department of Obstetrics and Gynecology, Keimyung University School of Medicine) ;
  • Rhee, Jeong-Ho (Department of Obstetrics and Gynecology, Keimyung University School of Medicine)
  • 투고 : 2011.02.15
  • 심사 : 2011.03.10
  • 발행 : 2011.03.02
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초록

Objective: This study was aimed to investigate endometrial histology and to find predictable clinical factors for endometrial disease (hyperplasia or cancer) in women with polycystic ovary syndrome (PCOS). Methods: We investigated the endometrial histology and analyzed the relationship between endometrial histology and clinical parameters, such as LH, FSH, estradiol, testosterone, fasting and 2 hours postprandial glucose and insulin, insulin resistance, body mass index, endometrial thickness, menstrual status from 117 women with PCOS. Statistical analysis was performed with chi square and t-test, p-value<0.05 was considered as statistically significant. And receiver operating characteristic curve was used to find predictable clinical factors for endometrial disease and to decide the cuff off values. Results: In 117 women with PCOS, endometrial histologic profiles are as follows: proliferative phase in 90 women (76.9%), endometrial hyperplasia in 25 women (21.4%), and endometrial cancer in 2 women (1.7%). Of 25 women with endometrial hyperplasia, simple hyperplasia without atypia, complex hyperplasia without atypia and complex hyperplasia with atypia were diagnosed in 15 (12.8%), 6 (5.1%), 4 (3.4%) women, respectively. Age and endometrial thickness were significantly related with endometrial disease, p=0.013 and p=0.001, respectively. At the cut off level of 25.5 years in age, sensitivity and specificity predicting for endometrial disease were 70.4% and 55.6%, respectively (p=0.023). At the cut off level of 8.5 mm in endometrial thickness, sensitivity and specificity were 77.8% and 56.7%, respectively (p=0.000). Conclusion: In women with PCOS, the incidence of endometrial hyperplasia and cancer were 21.4% and 1.7%. The age and endometrial thickness may be used as clinical determining factors for endometrial biopsy.

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참고문헌

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피인용 문헌

  1. Estrogen receptor β: the guardian of the endometrium vol.21, pp.2, 2015, https://doi.org/10.1093/humupd/dmu053
  2. The evaluation of endometrial sulfate glycosaminoglycans in women with polycystic ovary syndrome vol.31, pp.4, 2015, https://doi.org/10.3109/09513590.2014.989980
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