Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Indirect Determination of Cetirizine Hydrochloride by ICP-AES

  • Wang, Li-Sheng (College of Chemistry and Chemical Engineering, Guangxi University) ;
  • Wei, Xiao-Ling (College of Chemistry and Chemical Engineering, Guangxi University) ;
  • Gong, Qi (College of Chemistry and Chemical Engineering, Guangxi University) ;
  • Jiang, Zhi-Liang (School of Environment and Resource, Guangxi Normal University) ;
  • Li, Dong-Mei (College of Chemistry and Chemical Engineering, Guangxi University) ;
  • Liang, Qing (College of Chemistry and Chemical Engineering, Guangxi University)
  • Received : 2010.11.10
  • Accepted : 2010.12.08
  • Published : 2011.02.20
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Abstract

Cetirizine hydrochloride reacted with $BiI_4^-$ in an acidic aqueous solution to form precipitate. After centrifugation, the atomic emission intensity of $Bi^{3+}$ contained in the supernatant solution was measured at the characteristic wavelength of 206.170 nm. The difference between the spectral signal intensity of the blank solution and that of the supernatant, ${\Delta}I$, was linearly related to the concentration of cetirizine hydrochloride. As a result, a new inductively coupled plasmaatomic emission spectrometric (ICP-AES) method was developed for the analysis of cetirizine hydrochloride. The linear range was from 27.7 to 184.8 $mg{\cdot}L^{-1}$, with a correlation coefficient (r) of 0.9961 and a detection limit of 9.6 $mg{\cdot}L^{-1}$. This method is simple and accurate, Without using toxic organic solvents, and is feasible for the quality control of cetirizine hydrochloride tablets and capsules.

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