DOI QR코드

DOI QR Code

Interleukin-6 (-636 C/G) Gene Polymorphism in Korean Children With Kawasaki Disease

  • Ahn, Hye-Mi (Department of Pediatrics, School of Medicine, Ewha Womans University) ;
  • Park, In-Sook (Department of Pediatrics, College of Medicine, University of Ulsan) ;
  • Hong, Soo-Jong (Department of Pediatrics, College of Medicine, University of Ulsan) ;
  • Hong, Young-Mi (Department of Pediatrics, School of Medicine, Ewha Womans University)
  • 발행 : 2011.06.30

초록

Background and Objectives: Kawasaki disease (KD) is a multi-systemic vasculitis with coronary artery involvement. Serum interleukin (IL)-6 levels during acute phase showed a significant correlation with the duration of fever in patients with KD who were not treated with intravenous immunoglobulin (IVIG), suggesting that the regulation of IL-6 expression in KD patients may differ from that in normal children. However, there are controversies surrounding the association between IL-6 (-636 C/G) gene polymorphism and development of KD. Subjects and Methods: One hundred and nine children with KD and 191 children with congenital heart disease were included in this study. Echocardiography was performed to examine cardiac involvement in patients with KD. Genotyping of the IL-6 (-636 C/G) gene polymorphism was performed using the single-base extension method, and serum IL-6 concentrations were estimated using the sandwich enzyme immunoassay method. Results: Neutrophil, platelet count, liver function test, total protein and albumin concentrations were significantly different in the KD group and the serum IL-6 concentration was significantly higher in the KD group than the control group. There was no difference between the patients with coronary arterial dilatation (CAD) and those without CAD in the IL-6 (-636 C/G) polymorphism. The serum albumin concentration was significantly lower in patients with KD who had the -636 C/G or GG genotype compared with the control group. The serum IL-6 concentration was significantly higher in patients with KD who had the -636 C/G or GG genotype. Conclusion: There was no association between the IL-6 (-636 C/G) gene polymorphism and development of coronary arterial lesions in KD. Further multicenter studies are required to establish the relationship between the IL-6 (-636 C/G) gene polymorphism and development of KD.

키워드

참고문헌

  1. Yeo JS, Choi JW. Effectiveness of medium-dose intravenous immuno-globulin (1 g/kg) in the treatment of Kawasaki disease. Korean Circ J 2010;40:81-5. https://doi.org/10.4070/kcj.2010.40.2.81
  2. Lee SJ, Ahn HM, Yoo JH, Hong YM. Carotid intima-media thickness and pulse wave velocity after recovery from Kawasaki disease. Korean Circ J 2009;39:264-9. https://doi.org/10.4070/kcj.2009.39.7.264
  3. Wang CL, Wu YT, Liu CA, Kuo HC, Yang KD. Kawasaki disease in-fection, immunity and genetics. Pediatr Infect Dis J 2005;24:998-1004. https://doi.org/10.1097/01.inf.0000183786.70519.fa
  4. Fulton DR, Newberger JW. Long-term cardiac sequelae of Kawasaki disease. Curr Rheumatol Rep 2000;2:324-9. https://doi.org/10.1007/s11926-000-0070-2
  5. Kato H, Sugimura T, Akagi T, et al. Long-term consequences of Kawa-saki disease: a 10- to 21-year follow-up study of 594 patients. Circulation 1996;94:1379-85. https://doi.org/10.1161/01.CIR.94.6.1379
  6. Lloyd AJ, Walker C, Wilkinso M. Kawasaki disease: is it caused by an infectious agent? Br J Biomed Sci 2001;58:122-8.
  7. Liang SJ, Cheong HI, Noh CI, Yun YS. Role of anti-endothelial cell antibody in the development of coronary arterial lesions in Kawasaki disease. Korean Circ J 2006;36:723-31.
  8. Maury CP, Salo E, Pelkonen D. Circulating interleukin-1 beta in patients with Kawasaki disease. N Engl J Med 1988;319:1670-1. https://doi.org/10.1056/NEJM198812223192515
  9. Ueno Y, Takano N, Kanegane H, et al. The acute phase nature of interluekin-6: studies in Kawasaki disease and other febrile illness. Clin Exp Immunol 1989;76:337-42.
  10. Hirano T, Akira S, Taga T, Kishimoto T. Biological and clinical aspects of interluekin-6. Immunol Today 1990;11:443-9.
  11. Tanaka C, Mannami T, Kamide K, et al. Single nucleotide polymorphisms in the interleukin-6 gene associated with blood pressure and ath-erosclerosis in a Japanese general population. Hypertens Res 2005; 28:35-41. https://doi.org/10.1291/hypres.28.35
  12. Kim MK, Kim DS. The interleukin-6 level in Kawasaki disease. J Korean Pediatr Soc 1992;35:515-26.
  13. Research Committee on Kawasaki Disease. Report of Subcommittee on Standardization of Diagnostic Criteria and Reporting of Coronary Artery Lesions in Kawasaki Disease. Tokyo, Japan: Ministry of He-alth and Welfare;1984.
  14. Hong YM, Jin HS, Park IS, Hong SJ. Association of the matrix metalloproteinase-3 (-439C/G) gene polymorphism with Kawasaki disease in Korean children. Heart Vessels 2008;23:341-7. https://doi.org/10.1007/s00380-008-1041-1
  15. Hirao J, Hibi S, Andoh T, Ichimura T. High levels of circulating inter-leukin-4 and interleukin-10 in Kawasaki disease. Int Arch Allergy Immunol 1997;112:152-6. https://doi.org/10.1159/000237447
  16. Cheung YF, Huang GY, Chen CB, et al. Inflammatory gene polymorphisms and susceptibility to Kawasaki disease and its arterial sequelae. Pediatrics 2008;122:e608-14. https://doi.org/10.1542/peds.2008-0646
  17. Leung DY, Geha RS, Newberger JW, et al. Two monokines, interleukin-1 and tumor necrosis factor, render cultured vascular endothelial cells susceptible to lysis by antibodies circulating during Kawasaki syndrome. J Exp Med 1986;164:1958-72. https://doi.org/10.1084/jem.164.6.1958
  18. Hata A, Onouchi Y. Susceptibility genes for Kawasaki disease: toward implementation of personalized medicine. J Hum Genet 2009;54:67-73. https://doi.org/10.1038/jhg.2008.9
  19. Blake GJ, Ridker PM. Inflammatory bio-markers and cardiovascular risk prediction. J Intern Med 2002;252:283-94. https://doi.org/10.1046/j.1365-2796.2002.01019.x
  20. Zee RY, Cook NR, Cheng S, et al. Polymorphism in the P seletin and interleukin-4 genes as determinants of stroke: a population-based, pro-spective genetic analysis. Hum Mol Genet 2004;13:389-96.
  21. Chapman CM, Beilby JP, Humphries SE, Palmer LJ, Thompson PL, Hung J. Association of an allelic variant of interleukin-6 with subclini-cal carotid atherosclerosis in an Australian community population. Eur Heart J 2003;24:1494-9. https://doi.org/10.1016/S0195-668X(03)00313-0
  22. Jibiki T, Terai M, Shima M, et al. Monocyte chemoattractant protein 1 gene regulatory region polymorphism and serum levels of monocyte chemoattractant protein 1 in Japanese patients with Kawasaki disease. Arthritis Rheum 2001;44:2211-2. https://doi.org/10.1002/1529-0131(200109)44:9<2211::AID-ART375>3.0.CO;2-A
  23. Fishman D, Faulds G, Jeffery R, et al. The effect of novel polymorph-ism in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic onset juvenile chronic ar-thritis. J Clin Invest 1998;102:1369-76. https://doi.org/10.1172/JCI2629
  24. Burns JC, Shimizu C, Shike H, et al. Family-based association analy-sis implications IL-4 in susceptibility to Kawasaki disease. Genes Immun 2005;6:438-44. https://doi.org/10.1038/sj.gene.6364225
  25. Jin HS, Kim HB, Kim BS, et al. The IL-10 (-627 A/C) gene polymorph-ism may be associated with coronary aneurysms and low albumin in Ko-rean children with Kawasaki disease. Pediatr Res 2007;61:584-7. https://doi.org/10.1203/pdr.0b013e3180459fb5
  26. Linker-Israeli M, Wallace DJ, Prehn JL, Nand R, Li L, Klinenberg JR. A greater variability in the 3'flanking region of the IL-6 gene in pa-tients with systemic lupus erythematosus (SLE). Autoimmunity 1996; 23:199-209. https://doi.org/10.3109/08916939608995343
  27. Papassotiropoulos A, Bagli M, Jessen F, et al. A genetic variation of the inflammatory cytokine interleukin-6 delays the initial onset and reduces the risk for sporadic Alzheimer's disease. Ann Neurol 1999;45: 666-8. https://doi.org/10.1002/1531-8249(199905)45:5<666::AID-ANA18>3.0.CO;2-3
  28. Morgan L, Cooper J, Montgomery H, Kitchen N, Humphries SE. The interleukin-6 gene -174G>C and -572G>C promoter polymorphisms are related to cerebral aneurysms. J Neurol Neurosurg Psychiatry 2006;77:915-7. https://doi.org/10.1136/jnnp.2005.081976
  29. Sohn MH, Hur MW, Kim DS. Interleukin-6 gene gene polymorphism is not associated with Kawasaki disease. Genes Immun 2001;2:357-62. https://doi.org/10.1038/sj.gene.6363785

피인용 문헌

  1. Lack of association between miR-218 rs11134527 A>G and Kawasaki disease susceptibility vol.38, pp.3, 2011, https://doi.org/10.1042/bsr20180367
  2. The IL-1B Gene Polymorphisms rs16944 and rs1143627 Contribute to an Increased Risk of Coronary Artery Lesions in Southern Chinese Children with Kawasaki Disease vol.2019, pp.None, 2011, https://doi.org/10.1155/2019/4730507