Journal of the Korean Society of Radiology (대한영상의학회지)

The Korean Society of Radiology (대한영상의학회)
권호 표지

Measurement of Trabecular Bone Parameters in Porcine Vertebral Bodies Using Multidetector CT: Evaluation of Reproducibility of 3-Dimensional CT Histomorphometry

다중검출기 CT를 이용한 돼지 척추뼈의 미세골구조분석: 삼차원 CT 조직형태계측법의 재현성 평가

  • An, Sang-Bu (Department of Radiology, National Cancer Center) ;
  • Hong, Sung-Hwan (Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine) ;
  • Goo, Jin-Mo (Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine) ;
  • Moon, Kyung-Chul (Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine) ;
  • Kim, Kwang-Gi (Department of Biomedical Engineering, Division of Basic and Applied Sciences, National Cancer Center)
  • 안상부 (국립암센터 영상의학과) ;
  • 홍성환 (서울대학교병원 영상의학과, 서울대학교 의과대학 영상의학교실) ;
  • 구진모 (서울대학교병원 영상의학과, 서울대학교 의과대학 영상의학교실) ;
  • 문경철 (서울대학교병원 병리과, 서울대학교 의과대학 병리학교실) ;
  • 김광기 (국립암센터 의공학연구과)
  • Published : 2011.05.01
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Abstract

Purpose: To evaluate the reproducibility of 3-dimensional histomorphometry for the microarchitecture analysis of trabecular bone parameters using multidetector computed tomography (MDCT). Materials and Methods: Thirty-six specimens from porcine vertebral bodies were imaged five times with a 64-detector row MDCT system using the same scan protocols. Locations of the specimens were nearly identical through the scans. Three-dimensional structural parameters of trabecular bone were derived from the five data sets using image analyzing software. The features measured by the analysis programs were trabecular bone volume, trabecular bone volume/tissue volume, trabecular thickness, trabecular separation, trabecular number, trabecular bone pattern factor, structural model index. Results: The structural trabecular parameters showed excellent reproducibility through repeated scanning. Intraclass correlation coefficients of all seven structural parameters were in the range of 0.998 to 1.000. Coefficients of variation of the six structural parameters, excluding structural model index, were not over 1.6%. Conclusion: The measurement of the trabecular structural parameters using multidetector CT and three-dimensional histomophometry analysis program was validated and showed excellent reproducibility. This method could be used as a noninvasive and easily available test in a clinical setting.

목적: 다중검출기 CT를 이용한 3차원 조직형태계측법을 통해 미세골구조 분석의 재현성을 평가하고자 하였다. 대상과 방법: 해면골구조가 비교적 잘 보이는 돼지 척추골 36개를 선별하여 CT 스캔을 시행하였다. 64채널 다중검출기 CT를 이용하여 각 검체에 대해 다섯 번씩 반복 스캔하였고 이때 검체의 위치와 스캔 파라미터(parameters)는 동일하게 유지하였다. 각각의 영상 데이터를 소프트웨어를 이용하여 분석함으로써 3차원 미세골구조를 측정하고 측정치를 비교하여 미세골구조 분석의 재현성을 평가하였다. 측정한 3차원 미세골구조 지표들은 trabecular bone volume, trabecular bone volume/tissue volume, trabecular thickness, trabecular separation, trabecular number, trabecular bone pattern factor, structural model index였다. 결과: 미세골구조 지표들은 반복스캔에서 등급 내 상관계수가 0.998 - 1.000으로 측정되었고 structural model index를 제외한 6개 지표에서는 각각의 변동계수의 평균이 1.6%를 넘지않아 우수한 재현성을 보였다. 결론: 다중검출기 CT를 이용한 3차원 조직형태계측법은 미세골구조 분석에서 매우 재현성이 높은 검사임을 확인하였다. 이 방법은 임상 영역에서도 비침습적으로 쉽게 적용할 수 있을 것으로 생각한다.

Keywords

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