The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Case of Synchronous Primary Gastric Diffuse Large B-Cell Lymphoma and Hepatocellular Carcinoma

원발성 미만성 B세포 위림프종과 간세포암이 병발된 1예

  • Jung, Min-Wook (Department of Internal Medicine, Ajou University School of Medicine) ;
  • Lee, Hong-Sub (Department of Internal Medicine, Ajou University School of Medicine) ;
  • Song, Jun-Ha (Department of Internal Medicine, Ajou University School of Medicine) ;
  • Kim, Sun-Mi (Department of Internal Medicine, Ajou University School of Medicine) ;
  • Kim, Hyun-Kyung (Department of Internal Medicine, Ajou University School of Medicine) ;
  • Lee, Hyo-Jung (Department of Internal Medicine, Ajou University School of Medicine) ;
  • Jung, Seong-Hyun (Department of Internal Medicine, Ajou University School of Medicine)
  • 정민욱 (아주대학교 의과대학 내과학교실) ;
  • 이홍섭 (아주대학교 의과대학 내과학교실) ;
  • 송준하 (아주대학교 의과대학 내과학교실) ;
  • 김선미 (아주대학교 의과대학 내과학교실) ;
  • 김현경 (아주대학교 의과대학 내과학교실) ;
  • 이효정 (아주대학교 의과대학 내과학교실) ;
  • 정성현 (아주대학교 의과대학 내과학교실)
  • Published : 2011.09.01
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Abstract

Primary gastric lymphoma is relatively rare in the context of gastric malignancies. Synchronous primary gastric lymphoma and hepatocellular carcinoma (HCC) are even rarer. We report a case of synchronous primary gastric lymphoma and HCC in a 46-year-old man that appeared to be associated with hepatitis B virus infection. Pathologic examination and immunohistochemical analysis of gastric and liver specimens showed diffuse large B-cell lymphoma and HCC, respectively. The patient was initially treated for primary gastric lymphoma with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone) chemotherapy. During the chemotherapy interval, he was treated for HCC by transarterial chemoembolization (TACE) and laparoscopy-assisted left hemihepatectomy.

위에 발생하는 악성종양 중 원발성 위림프종은 상당히 드문편으로 동시에 간세포암이 병발한 경우는 매우 드물다. 본 증례는 원발성 위림프종과 간세포암의 병발로 진단된 46세 남자에 대한 보고로서 각각의 종양에 대하여 조직검사 및 면역조직화학 검사를 시행하여 진단하였다. 림프종에 대하여는 R-CHOP 항암화학요법(rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone)을 시행하여 완전관해를 하였고, 항암화학요법 중간에 간동맥 화학 색전술 및 간좌엽 절제술을 시행하여 간세포암에 대한 근치적 치료를 시행하였고, 현재 추적관찰 중이다.

Keywords

References

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