Journal of Cardiovascular Imaging

  • 제19권1호
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  • Pages.26-31
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  • 2011
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  • 2586-7210(pISSN)
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  • 2586-7296(eISSN)
한국심초음파학회 (Korean Society of Echocardiography)
권호 표지
DOI QR코드

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CORRELATION BETWEEN N-TERMINAL PRO-BRAIN NATRIURETIC PEPTIDE AND DOPPLER ECHOCARDIOGRAPHIC PARAMETERS OF LEFT VENTRICULAR FILLING PRESSURE IN ATRIAL FIBRILLATION

  • Kim, Woo-Shin (Division of Cardiology, Department of Internal Medicine, Medical Research Center, Mokdong Hospital, School of Medicine, Ewha Womans University) ;
  • Park, Seong-Hoon (Division of Cardiology, Department of Internal Medicine, Medical Research Center, Mokdong Hospital, School of Medicine, Ewha Womans University)
  • 발행 : 2011.03.27
⟨ 이전 논문 다음 논문 ⟩

초록

Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia with a population prevalence of about 1%. Natriuretic peptide level is elevated in patients with AF with diastolic dysfunction even with a normal left ventricular (LV) ejection fraction. The N-terminal pro-brain natriuretic peptide (NT-proBNP) level and Doppler echocardiographic parameters for diastolic function have shown correlation with LV filling pressures. We aimed to evaluate the relationship between echocardiographic parameters and serum NT-proBNP in patients with AF with preserved LV ejection fraction. Methods: We examined transthoracic echocardiography and NT-proBNP levels in the patients with AF and patients with sinus rhythm. Blood samples were taken for serum NT-proBNP measurements within 24 hours of echocardiographic examination. The group 1 was the patients with sinus rhythm (n = 30, mean age 68 ${\pm}$ 13 years) and the group 2 was the patients with AF (n = 33, mean age 70 ${\pm}$ 14 years). Results: The group 2 patients had significantly higher mitral E, E' (lateral annulus), E/E' (septal annulus), left atrial (LA) volume index, LA size, pulmonary vein diastolic velocity, and NT-proBNP level than those of group 1 patients (p < 0.05). The area under the receiver-operating characteristic curve showed a NT-proBNP had good diagnostic power for E/E' (septal annulus) > 15 in patients with AF at cutoff value of 433 pg/mL. Conclusion: NT-proBNP level is well correlated with Doppler echocardiographic parameters of diastolic function in patients with AF and preserved LV ejection fraction. NT-proBNP level more than 433 pg/mL may suggest elevated LV filling pressure in patients with AF.

키워드

참고문헌

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피인용 문헌

  1. Letter by Bonaque et al Regarding Article, “Cardiac Biomarkers Are Associated With an Increased Risk of Stroke and Death in Patients With Atrial Fibrillation: A Randomized Evaluation of Long-Ter vol.127, pp.2, 2013, https://doi.org/10.1161/circulationaha.112.114421
  2. Usefulness of Upper and Lower Limb Muscles Strength in the Evaluation of Clinical Severity of Heart Failure in Elderly Patients vol.9, pp.5, 2011, https://doi.org/10.4236/wjcd.2019.95033