Korean Journal of Radiology

  • 제12권4호
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  • Pages.456-462
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  • 2011
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  • 1229-6929(pISSN)
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  • 2005-8330(eISSN)
대한영상의학회 (The Korean Society of Radiology)
권호 표지
DOI QR코드

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The Serum CA-125 Concentration Data Assists in Evaluating CT Imaging Information When Used to Differentiate Borderline Ovarian Tumor from Malignant Epithelial Ovarian Tumors

  • Shin, Ji-Eun (Department of Radiology and the Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Choi, Hyuck-Jae (Department of Radiology and the Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Kim, Mi-Hyun (Department of Radiology and the Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Cho, Kyoung-Sik (Department of Radiology and the Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center)
  • 발행 : 2011.08.01
⟨ 이전 논문 다음 논문 ⟩

초록

Objective: We wanted to evaluate the diagnostic value of serum CA-125 concentration, when used in combination with the preoperative contrast-enhanced CT results, to differentiate borderline ovarian tumors (BOTs) from stage I malignant epithelial ovarian tumors (MEOTs). Materials and Methods: Ninety-eight masses (46 BOTs and 52 stage I MEOTs) from 87 consecutive patients (49 with BOTs and 38 with stage I MEOTs) who had undergone preoperative contrast-enhanced computed tomography (CT) and surgical staging were evaluated retrospectively and independently by two radiologists. The preoperative serum CA-125 concentration was measured in all patients. The utility of analyzing serum CA-125 concentration in combination with the CT results was evaluated by receiver operating characteristic (ROC) curve analysis. Results: An irregular tumor surface and lymphadenopathy were predictive of a MEOT. ROC analysis showed that the combination of CT data and the serum CA-125 level resulted in a higher diagnostic performance than did using the CT alone for differentiating BOTs from MEOTs. The areas under the curves (AUCs) without and with the use of the serum CA-125 level data were 0.67 (95% confidence interval [CI]: 0.57-0.77) and 0.78 (95% CI: 0.68-0.85), respectively, for reader 1 (p = 0.029) and 0.71 (95% CI: 0.61-0.80) and 0.81 (95% CI: 0.72-0.89), respectively, for reader 2 (p = 0.009). Conclusion: The serum CA-125 concentration is of additional diagnostic value when used in conjunction with the CT imaging results for differentiating BOTs from MEOTs.

키워드

참고문헌

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