Korean Circulation Journal

The Korean Society of Cardiology (대한심장학회)
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The Relationship Between Ambulatory Arterial Stiffness Index and Blood Pressure Variability in Hypertensive Patients

  • Lee, Hyung-Tak (Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Lim, Young-Hyo (Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Kim, Bae-Keun (Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Lee, Kang-Won (Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Lee, Jae-Ung (Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Kim, Kyung-Soo (Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Kim, Soon-Gil (Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Kim, Jeong-Hyun (Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Lim, Heon-Kil (Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Shin, Jin-Ho (Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Kim, Yu-Mi (Department of Preventive Medicine, Dong-A University College of Medicine)
  • Published : 2011.05.30
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Abstract

Background and Objectives: Ambulatory arterial stiffness index (AASI) is well known as a predictor of cardiovascular mortality in hypertensive patients. Mathematically, AASI reflect the standard deviation (SD) of blood pressure (BP) variation. AASI is measured higher levels in non-dipper than dipper. Thus, AASI has a possibility of not only reflecting arterial stiffness but also BP variability and/or autonomic nervous dysfunction. Subjects and Methods: Consecutive data from 418 untreated hypertensive patients were analyzed retrospectively. We examined the association between the 24-hour ambulatory BP monitoring (ABPM) parameters and AASI. Results: AASI had a simple correlation with age (R=0.189, p<0.001), relative wall thickness (RWT) (R=0.115, p=0.019), left ventricular mass index (LVMI) (R=0.192, p<0.001), average systolic BP (SBP) (R=0.232, p<0.001), average pulse pressure (PP) (R=0.363, p<0.001), SD of diastolic BP (DBP) (R=-0.352, p<0.001), SD of PP (R=0.330, p<0.001), SD of heart rate (HR) (R=-0.268, p<0.001), and nocturnal dipping (R=-0.137, p=0.005). In multiple linear regression analysis model including clinical parameters and 24 hour-ABPM parameters, independent predictors of AASI were SD of PP (${\beta}$=1.246, p<0.001), SD of DBP (${\beta}$=-1.067, p<0.001), SD of SBP (${\beta}$=-0.197, p<0.001), and non-dipper (${\beta}$=0.054, p=0.033). Conclusion: AASI is closely correlated with BP variability. The result of this study shows that AASI is not only a parameter for arterial stiffness, but also a parameter for BP variability.

Keywords

References

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