The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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A Case of Acute Renal Failure Induced by Acetaminophen Intoxication

아세트아미노펜 중독에 의한 급성 신부전 1예

  • Lee, Ji-Yeon (Department of Internal Medicine, Soonchunhyang University College of Medicine, Soonchunhyang University Cheonan Hospital) ;
  • Gil, Hyo-Wook (Department of Internal Medicine, Soonchunhyang University College of Medicine, Soonchunhyang University Cheonan Hospital) ;
  • Yang, Jong-Oh (Department of Internal Medicine, Soonchunhyang University College of Medicine, Soonchunhyang University Cheonan Hospital) ;
  • Lee, Eun-Young (Department of Internal Medicine, Soonchunhyang University College of Medicine, Soonchunhyang University Cheonan Hospital) ;
  • Hong, Sae-Yong (Department of Internal Medicine, Soonchunhyang University College of Medicine, Soonchunhyang University Cheonan Hospital)
  • 이지연 (순천향대학교 의과대학 순천향대학교천안병원 신장내과) ;
  • 길효욱 (순천향대학교 의과대학 순천향대학교천안병원 신장내과) ;
  • 양종오 (순천향대학교 의과대학 순천향대학교천안병원 신장내과) ;
  • 이은영 (순천향대학교 의과대학 순천향대학교천안병원 신장내과) ;
  • 홍세용 (순천향대학교 의과대학 순천향대학교천안병원 신장내과)
  • Published : 2011.03.01
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Abstract

Acetaminophen is a widely used analgesic and antipyretic. Acetaminophen-induced kidney injury is poorly described. Hepatorenal syndrome, prerenal failure, and direct toxicity of acetaminophen metabolites could be involved in the development of acute renal failure with acetaminophen intoxication. We treated a 58-year-old female who was found stuporous and brought to the emergency room by ambulance. She had ingested acetaminophen 4~5 g per day for a chronic headache for over 10 years. At presentation, she had ingested about 8 g of acetaminophen. She presented in non-oliguric acute renal failure with hepatic injury. Hemoperfusion, hemodialysis, and N-acetylcysteine infusion were applied. The creatinine peaked on the sixth day. Subsequently, her renal function recovered. After 34 days, she was discharged in relatively good condition. In conclusion, supportive care and proper extracorporeal therapy can improve the survival in acute renal failure after acetaminophen intoxication.

아세트아미노펜에 의한 급성 신부전은 잘 알려져 있지 않으며 그 치료에 대해서도 확립되어 있지 않다. 저자들은 58세 여자 환자가 과량의 아세트아미노펜 중독으로 인해 급성 신부전이 발생하였으나 N-acetylcystein 투여와 적절한 혈액 관류 및 혈액 투석으로 성공적으로 치료하였기에 보고하는 바이다.

Keywords

References

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