한국간담췌외과학회지 (Annals of Hepato-Biliary-Pancreatic Surgery)

  • 제15권2호
  • /
  • Pages.128-133
  • /
  • 2011
  • /
  • 2508-5778(pISSN)
  • /
  • 2508-5859(eISSN)
한국간담췌외과학회 (The Korean Association of Hepato-Biliary-Pancreatic Surgery)
권호 표지

Fat Tissue Infiltration into the Pancreas Parenchyme and Its Effect on the Result of Surgery

  • Yoon, Sang-Ho (Departments of Surgery, Korea Cancer Center Hospital) ;
  • Cho, Eung-Ho (Departments of Surgery, Korea Cancer Center Hospital) ;
  • Kim, Sang-Bum (Departments of Surgery, Korea Cancer Center Hospital) ;
  • Park, Sun-Hoo (Departments of Pathology, Korea Cancer Center Hospital)
  • 발행 : 2011.05.30
⟨ 이전 논문 다음 논문 ⟩

초록

Purpose: In Korea, there are few reports regarding the infiltration of fat tissue in pancreatic parenchyma in surgically resected organs. It is necessary to ascertain the correlation between the presence of fat tissue in the resection margin of the pancreas and the surgery outcome. Methods: Fifty four patients who underwent pancreatic resection from Jan. 2007 to Nov. 2008 were enrolled in this study. Pathologic examination was performed to determine the presence of fat tissue in resected pancreatic parenchyma. Statistical correlation between the presence of fat tissue with clinical parameters and postoperative complication rates was analyzed. Results: Among the specimens of all fifty four patients, fat tissue was found in 32 specimens of patients (59.3%). Female gender and patients whose body mass index exceeded 24 kg/$m^{2}$ were statistically correlated with the presence of the fat tissue in pancreatic parenchyma. There was no statistical relationship between infiltration of fat tissue with postoperative complications. Conclusion: This study may serve as the base data for study in radiological imaging in detecting pancreatic tissue. A further larger scaled study is needed to validate the result of this study.

키워드

참고문헌

  1. Yoo YW. Safe and easy pancreatojejunostomy. Korean J Hepatobiliary Pancreat Surg 2007;11:32-35.
  2. Yeo CJ, Cameron JL, Sohn TA, et al. Six hundred fifty consecutive pancreaticoduodenectomies in the 1990s: pathology, complications, and outcomes. Ann Surg 1997;226:248-257. https://doi.org/10.1097/00000658-199709000-00004
  3. Lillemoe KD, Cameron JL, Kim MP, et al. Does fibrin glue sealant decrease the rate of pancreatic fistula after pancreaticoduodenectomy? Results of a prospective randomized trial. J Gastrointest Surg 2004;8:766-772. https://doi.org/10.1016/j.gassur.2004.06.011
  4. Yeh TS, Jan YY, Jeng LB, et al. Pancreaticojejunal anastomotic leak after pancreaticoduodenectomy--multivariate analysis of perioperative risk factors. J Surg Res 1997;67:119-125. https://doi.org/10.1006/jsre.1996.4974
  5. Yeo CJ, Cameron JL, Maher MM, et al. A prospective randomized trial of pancreaticogastrostomy versus pancreaticojejunostomy after pancreaticoduodenectomy. Ann Surg 1995;222:580-588. https://doi.org/10.1097/00000658-199510000-00014
  6. Srivastava S, Sikora SS, Pandey CM, Kumar A, Saxena R, Kapoor VK. Determinants of pancreaticoenteric anastomotic leak following pancreaticoduodenectomy. ANZ J Surg 2001;71:511-515. https://doi.org/10.1046/j.1440-1622.2001.02184.x
  7. Yang YM, Tian XD, Zhuang Y, Wang WM, Wan YL, Huang YT. Risk factors of pancreatic leakage after pancreaticoduodenectomy. World J Gastroenterol 2005;11:2456-2461. https://doi.org/10.3748/wjg.v11.i16.2456
  8. Strasberg SM, Drebin JA, Mokadam NA, et al. Prospective trial of a blood supply-based technique of pancreaticojejunostomy: effect on anastomotic failure in the Whipple procedure. J Am Coll Surg 2002;194:746-758. https://doi.org/10.1016/S1072-7515(02)01202-4
  9. Yu HC, Cho BH. Modified dunking pancreaticojejunostomy. Korean J Hepatobiliary Pancreat Surg 2007;11:27-31.
  10. Mathur A, Pitt HA, Marine M, et al. Fatty pancreas: a factor in postoperative pancreatic fistula. Ann Surg 2007;246:1058-1064. https://doi.org/10.1097/SLA.0b013e31814a6906
  11. Ogilvie RF. The islands of Langerhans in 19 cases of obesity. J Pathol 1933;37:473-481. https://doi.org/10.1002/path.1700370314
  12. Olsen TS. Lipomatosis of the pancreas in autopsy material and its relation to age and overweight. Acta Pathol Microbiol Scand A 1978;86:367-373.
  13. Gullo L, Salizzoni E, Serra C, Calculli L, Bastagli L, Migliori M. Can pancreatic steatosis explain the finding of pancreatic hyperenzymemia in subjects with dyslipidemia? Pancreas 2006;33:351-353. https://doi.org/10.1097/01.mpa.0000240603.26312.2a
  14. Gaujoux S, Cortes A, Couvelard A, et al. Fatty pancreas and increased body mass index are risk factors of pancreatic fistula after pancreaticoduodenectomy. Surgery 2010;148:15-23. https://doi.org/10.1016/j.surg.2009.12.005
  15. Bassi C, Butturini G, Molinari E, et al. Pancreatic fistula rate after pancreatic resection. The importance of definitions. Dig Surg 2004;21:54-59. https://doi.org/10.1159/000075943
  16. Bassi C, Dervenis C, Butturini G, et al. Postoperative pancreatic fistula: an international study group (ISGPF) definition. Surgery 2005;138:8-13. https://doi.org/10.1016/j.surg.2005.05.001
  17. Lee SE, Jang JY, Lim CS, et al. Measurement of pancreatic fat by magnetic resonance imaging: predicting the occurrence of pancreatic fistula after pancreatoduodenectomy. Ann Surg 2010;251:932-936. https://doi.org/10.1097/SLA.0b013e3181d65483